Vidyodaya Journal of Science,
Год журнала:
2024,
Номер
27(02)
Опубликована: Дек. 30, 2024
Nanozymes,
artificial
nanomaterials
mimicking
enzyme
activity,
are
at
the
forefront
of
innovative
cancer
therapies,
particularly
in
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
and
photothermal
(PTT).
Their
capacity
to
selectively
generate
reactive
oxygen
species
under
tumor-specific
conditions,
including
low
pH
high
H₂O₂
levels,
facilitates
targeted
induction
cell
death
while
minimizing
damage
healthy
tissues.
When
integrated
with
PDT
or
PTT,
nanozymes
enhance
oxidative
stress
promote
immunogenic
death,
further
amplifying
anti-tumor
immune
responses.
Recent
advances
single-atom
intelligent
have
shown
promise
overcoming
therapeutic
limitations,
such
as
tumor
hypoxia
suppression
modulating
microenvironment
boost
treatment
efficacy.
Additionally,
ongoing
preclinical
clinical
evaluations
highlight
potential
synergistically
immunotherapy
outcomes.
advantages
over
traditional
enzymes,
stability,
tunability,
cost-effectiveness,
ability
maintain
catalytic
activity
hostile
environments,
position
transformative
agents
therapy.
However,
their
translation
faces
significant
challenges,
biocompatibility
concerns,
delivery
inefficiencies
sites,
stringent
regulatory
hurdles,
which
require
comprehensive
research
solutions
address.
Despite
these
advancements
nanozyme
design
functionalization
continue
pave
way
for
more
effective
safer
applications
will
be
discussed
detail
this
review.Keywords:
Cancer
therapy,
Nanomaterial,
ROS,
(PTT)
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(1), С. 4 - 4
Опубликована: Янв. 31, 2025
Regrettably,
despite
undeniable
advances
in
cancer
diagnosis
and
therapy,
primary
brain
(or
cancer)
remains
one
of
the
deadliest
forms
malignant
tumors,
where
glioblastoma
(GBM)
is
known
as
most
diffuse
glioma
astrocytic
lineage.
Fortunately,
to
improve
this
scenario,
remarkable
progress
nanotechnology
has
brought
new
promise
raised
expectations
treatment.
Nanomedicine,
principally
an
area
amalgamating
with
biology
medicine,
demonstrated
a
pivotal
role,
starting
earliest
detection
while
also
offering
novel
multimodal
therapy
alternatives.
In
vast
realm
nanotechnology,
nanozymes,
type
nanomaterial
intrinsic
enzyme-like
activities
characteristics
connecting
fields
nanocatalysts,
enzymology,
biology,
have
emerged
powerful
nanotools
for
theranostics.
Hence,
fascinating
field
research
experienced
exponential
growth
recent
years.
As
it
virtually
impossible
cover
all
literature
on
broad
domain
science
paper,
review
focuses
presenting
multidisciplinary
approach,
its
content
extending
from
fundamental
knowledge
nanozymes
enzyme-mimicking
catalysis
targeting
cancers.
Although
we
are
at
very
early
stages
research,
can
be
envisioned
that
strategic
development
theranostics
will
positively
offer
disruptive
nanoplatforms
future
nano-oncology.
Molecules,
Год журнала:
2025,
Номер
30(6), С. 1210 - 1210
Опубликована: Март 8, 2025
Rare
earth
metal
nanoparticles,
some
of
which
are
already
widely
used
in
medicine,
growing
interest
the
modern
scientific
community.
One
promising
rare
metals
for
biomedical
applications
is
cerium,
specifically
its
oxide
form,
characterized
by
a
higher
level
stability
and
safety.
According
to
number
studies,
cerium
dioxide
has
wide
range
biological
effects
(regenerative,
antimicrobial,
antioxidant,
antitumor),
justifies
potential
application
medicine.
However,
these
their
intensity
vary
significantly
across
studies.
Since
was
it
can
be
assumed
that
not
only
chemical
formula
important,
but
also
physicochemical
parameters
nanoparticles
obtained,
consequently
methods
synthesis
modification
with
use
excipients.
In
this
review,
we
considered
possibilities
using
excipients
(polyacrylate,
polyvinylpyrrolidone,
dextran,
hyaluronic
acid,
chitosan,
polycarboxylic
acids,
lecithin,
phosphatidylcholine)
context
preserving
properties,
as
well
degree
study
combinations
from
point
view
prospect
creating
drugs
based
on
applications.
