An In Vitro and In Silico Study of Luteolin-Loaded Zinc Oxide Nanoparticles: Enhancing Bioactivity and Efficacy for Advanced Therapeutic Applications Against Cariogenic Microorganisms DOI Open Access

Kethan Umakanth,

Taniya Mary Martin,

Meenakshi Sundaram K

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Introduction Recent studies have explored alternative methods to enhance caries prevention and treatment. Luteolin compound has been noted for its antimicrobial properties, while zinc nanoparticles (Zn NPs) are recognized their potent antibacterial effects. This study investigates the synthesis, characterization, efficacy of luteolin-loaded Zn oxide NPs (Luteo-ZnONPs) against cariogenic bacteria. By combining biofilm-targeting capabilities luteolin with properties NPs, we aim explore a novel approach dental management. Methods Luteo-ZnONPs were synthesized characterized using ultraviolet-visible (UV-vis) Fourier transform infrared (FTIR) spectroscopy, confirming successful formation stability. Antimicrobial was assessed through minimum inhibitory concentration (MIC), demonstrating effectiveness bacteria such as

Язык: Английский

Sources of Lipopeptides and Their Applications in Food and Human Health: A Review DOI Creative Commons
Shuyi Chen,

Chen Sumin,

Yu Xin

и другие.

Foods, Год журнала: 2025, Номер 14(2), С. 207 - 207

Опубликована: Янв. 10, 2025

Lipopeptides (LPs) are widely sourced surface-active natural products with a wide range of functions and low toxicity, high potency, good biodegradability. In this paper, we summarize, for the first time, plant, animal, microbial, synthetic sources LPs. We also introduce applications LPs in food human health, including (1) can inhibit growth microorganisms during production preservation. They be added to packaging materials preservation freshness transportation, used as additives improve taste food. (2) provide amino acids promote protein synthesis cellular repair. Due their broad-spectrum antimicrobial properties, they exhibit anticancer effects biological activities. This review summarizes, laying foundation development application

Язык: Английский

Процитировано

1

Mangrove pneumatophores as biocatalyst for the fabrication of silver nanoparticles and its potential applications against biofilm and hepatic carcinoma DOI Creative Commons
Debasis Nayak, Awdhesh Kumar Mishra, Kunal Biswas

и другие.

Nanoscale Advances, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The pneumatophore extract of Acanthus ilicifolius provides a unique microenvironment for the fabrication silver nanoparticles. synthesized AgNPs demonstrated enhanced antibacterial and anticancer efficacy.

Язык: Английский

Процитировано

0

WOUND HEALING EVALUATION OF NOVEL CISSUS QUADRANGULARIS, BIOCERAMICS AND TENDON EXTRACELLULAR MATRIX INCORPORATED SCAFFOLDS FOR PERIODONTAL BONE REGENERATION WITH ZEBRAFISH MODELS DOI

Srinivasa Sitaram,

Balaji Ganesh,

Gurumoorthy Kaarthikeyan

и другие.

BULLETIN OF STOMATOLOGY AND MAXILLOFACIAL SURGERY, Год журнала: 2025, Номер unknown, С. 206 - 215

Опубликована: Март 20, 2025

Background: Wound healing is a complex biological process involving, proliferation, and tissue remodelling, requiring advanced biomaterials to facilitate effective regeneration. This study evaluated the wound potential of composite scaffolds incorporating Cissus quadrangularis extract, carrageenan, tendon extracellular matrix (ECM) with bioceramics such as silver hydroxyapatite tricalcium phosphate using zebrafish model. Materials Methods: The were extensively characterized Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), X- ray diffraction (XRD) determine their physiochemical properties correlation efficacy. wild- type wounded treated following negative control (Group 1), (TEM) 2), Group 3 (contained + 2 components), 4 (Silver components) respectively for 21 days. closure ratio was assessed on 0, 7 14 days histological observations. Results: As results, SEM analysis revealed highly porous architecture interconnected pores, enhancing cellular adhesion, migration at site. surface roughness provided an optimal microenvironment fibroblast infiltration re-epithelization, accelerating process. FTIR confirmed presence hydroxyl, carboxyl, amide, groups indicating strong biomaterial interactions, hydration, bioactivity. observed peaks validated incorporation essential calcium ion release osteogenic differentiation. XRD patterns exhibited well- defined crystalline corresponding bioactive glass, ensuring stability, controlled degradation, prolonged bioactivity Zebrafish assays demonstrated significant improvements in closure, reduced inflammation, enhanced remodelling scaffold groups. histology observations that treatment induced rapid epidermal formation, immune cell activity, vascularization. Faster contraction new scale formation post injury, highlighting scaffold’s effectiveness compared slower recovery untreated controls. combined effects synergistic approach Conclusion: application phosphate, C. quadrangularis, TEM effectively promoted healing. Future research should focus optimizing composition validating efficacy mammalian models translational applications

Язык: Английский

Процитировано

0

Copper nanoparticles biosynthesis by Priestia megaterium and its application as antibacterial and antitumor agents DOI Creative Commons
Salma H Mohamed,

Badawi A. Othman,

Basma T. Abd-Elhalim

и другие.

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Окт. 9, 2024

The growth of material science and technology places high importance on creating better processes for synthesizing copper nanoparticles. Thus, an easy, ecological, benign process producing nanoparticles (CuNPs) has been developed using Priestia sp. bacteria utilizing a variety low-cost agro-industrial wastes byproducts. biosynthesis CuNPs was conducted glucose medium ions salt solution, then it replaced by wastes. UV-visible spectroscopy, dynamic light scattering (DLS), X-ray diffraction (XRD), High-resolution transmission electron microscope (HR-TEM), Attenuated Total Reflectance Fourier transform infrared (ATR-FTIR), zeta potential were used to characterize the biosynthesized CuNPs. cytotoxicity Vero -CCL-81 cell lines, antibacterial antitumor properties human colon epithelial colorectal adenocarcinoma Caco-2-HTB-37 lines assessed. DLS studies revealed formation, with maximum concentration 6.19 ppm after 48 h, as indicated 0.58 Surface plasmon resonance (SPR) within 450 nm 57.73 particle size. 16S rRNA gene analysis that isolate is closely related megaterium deposited in NCBI GenBank accession number AMD 2024. various blackstrap sugar cane molasses being most effective reducing size 3.12 owing stabilizing active compounds. free contaminants, sphere-shaped structure assessment IC

Язык: Английский

Процитировано

2

An In Vitro and In Silico Study of Luteolin-Loaded Zinc Oxide Nanoparticles: Enhancing Bioactivity and Efficacy for Advanced Therapeutic Applications Against Cariogenic Microorganisms DOI Open Access

Kethan Umakanth,

Taniya Mary Martin,

Meenakshi Sundaram K

и другие.

Cureus, Год журнала: 2024, Номер unknown

Опубликована: Авг. 28, 2024

Introduction Recent studies have explored alternative methods to enhance caries prevention and treatment. Luteolin compound has been noted for its antimicrobial properties, while zinc nanoparticles (Zn NPs) are recognized their potent antibacterial effects. This study investigates the synthesis, characterization, efficacy of luteolin-loaded Zn oxide NPs (Luteo-ZnONPs) against cariogenic bacteria. By combining biofilm-targeting capabilities luteolin with properties NPs, we aim explore a novel approach dental management. Methods Luteo-ZnONPs were synthesized characterized using ultraviolet-visible (UV-vis) Fourier transform infrared (FTIR) spectroscopy, confirming successful formation stability. Antimicrobial was assessed through minimum inhibitory concentration (MIC), demonstrating effectiveness bacteria such as

Язык: Английский

Процитировано

1