Insects, Год журнала: 2024, Номер 15(11), С. 886 - 886
Опубликована: Ноя. 13, 2024
To contrast the rapid spread of antibiotic resistance in bacteria, new alternative therapeutic options are urgently needed. The use nanoparticles as carriers for clinically relevant antibiotics represents a promising solution to potentiate their efficacy. In this study, we used
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1320 - 1320
Опубликована: Фев. 4, 2025
Melanogenesis and melanin deposition are processes essential for the effective immune response of insects to various invaders. Phenoloxidase (PO), produced in specialized cells as an inactive precursor prophenoloxidase (proPO), is key enzyme formation. The activated via limited proteolysis by a dedicated serine proteinase, which final element cascade proteinases (SPs) that make up PO system. provides different cytotoxic molecules active fighting infections, well melanin, important sequestration However, since reactive compounds generated during melanization also pose threat host cells, strict control system necessary self-protection. Different pathogens parasites influence through strategies, allow them survive develop insect body. In this review, we characterize “the lights shadows” activation, indicating, on one hand, its advantages efficient mechanism and, other dangers associated with improper functioning selected strategies regulating activity entomopathogenic organisms.
Язык: Английский
Процитировано
0
Insect Science, Год журнала: 2025, Номер unknown
Опубликована: Апрель 9, 2025
Abstract The basic helix–loop–helix (bHLH) domain transcription factors precisely regulate various developmental processes in insects. Dimm, a specific bHLH factor, integrates the insulin/insulin‐like growth factor signaling (IIS) and juvenile hormone (JHS) pathways to modulate larval development silkworms. However, molecular mechanisms underlying this regulation are not yet fully understood. This study aimed determine targets of Dimm through which it regulates development. Chromatin immunoprecipitation followed by sequencing (ChIP‐seq) revealed ganglioside‐induced differentiation‐associated protein 2 ( GDAP2 ) as direct downstream target gene Dimm. Further showed that directly binds an enhancer element located second intron promote its transcription. exhibited widespread expression across different stages tissues silkworms, regulated both IIS JHS pathways. systemic knockout leads delayed with significant reduction body weight; moreover, was arrested at 4th‐instar stage. investigation unveiled inhibition ecdysone innate immune mutant line led abnormal A systematic biological functions offers valuable insights into mechanism
Язык: Английский
Процитировано
0
Journal of Invertebrate Pathology, Год журнала: 2025, Номер unknown, С. 108343 - 108343
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Insects, Год журнала: 2024, Номер 15(11), С. 886 - 886
Опубликована: Ноя. 13, 2024
To contrast the rapid spread of antibiotic resistance in bacteria, new alternative therapeutic options are urgently needed. The use nanoparticles as carriers for clinically relevant antibiotics represents a promising solution to potentiate their efficacy. In this study, we used
Язык: Английский
Процитировано
0