Circadian Regulation of Drug Responses: Toward Sex-Specific and Personalized Chronotherapy
The Annual Review of Pharmacology and Toxicology,
Год журнала:
2023,
Номер
64(1), С. 89 - 114
Опубликована: Сен. 19, 2023
Today's
challenge
for
precision
medicine
involves
the
integration
of
impact
molecular
clocks
on
drug
pharmacokinetics,
toxicity,
and
efficacy
toward
personalized
chronotherapy.
Meaningful
improvements
tolerability
and/or
medications
through
proper
administration
timing
have
been
confirmed
over
past
decade
immunotherapy
chemotherapy
against
cancer,
as
well
commonly
used
pharmacological
agents
in
cardiovascular,
metabolic,
inflammatory,
neurological
conditions.
Experimental
human
studies
recently
revealed
sexually
dimorphic
circadian
responses.
Dedicated
randomized
clinical
trials
should
now
aim
to
issue
recommendations
daily
medical
practice,
integrating
innovative
technologies
remote
longitudinal
monitoring
metrics,
statistical
prediction
clock
function
from
single-timepoint
biopsies,
multiscale
biorhythmic
mathematical
modelling.
Importantly,
chronofit
patients
with
a
robust
function,
who
would
benefit
most
chronotherapy,
need
be
identified.
Conversely,
nonchronofit
could
emerging
class
chronobiotics
targeting
clock.
Язык: Английский
Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment
Current Opinion in Systems Biology,
Год журнала:
2024,
Номер
37, С. 100506 - 100506
Опубликована: Фев. 29, 2024
The
growing
numbers
of
cancer
cases
represent
a
medical
and
societal
burden
worldwide.
More
than
half
all
patients
are
treated
with
chemotherapy.
Yet,
chemotherapeutic
drugs
kill
not
only
cells,
but
also
healthy
tissue,
causing
massive
adverse
side
effects.
Recent
research
on
circadian
medicine
suggests
that
side-effects
can
be
reduced,
treatment
efficacy
increased,
by
considering
the
biological
clock
patients.
Integrating
profiles
molecular
markers
in
personalized
mathematical
models
simulate
individual
dynamics
drug
uptake,
action
cellular
response
to
This
requires
advanced
computational
tools
balance
prediction
quality
overfitting.
Personalized
will
eventually
lead
an
optimal
alignment
timing
inner
patient,
reducing
effects,
increasing
enhancing
patient
well-being.
Язык: Английский
Time matters: chrono-pharmacotherapy as precision medicine
Asia-Pacific Journal of Pharmacotherapy & Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
The
circadian
clock
and
its
inherent
rhythms
serve
as
the
foundation
for
regulating
many
of
body’s
vital
processes.
Recent
advances
in
medicine
have
leveraged
these
natural
cycles
through
chronotherapy,
practice
timing
drug
administration
to
align
with
body's
internal
clock,
enhance
treatment
outcomes.
Endogenous
clocks
not
only
dictate
physiological
but
also
influence
how
drugs
are
absorbed,
distributed,
metabolized,
excreted,
thereby
affecting
both
their
therapeutic
efficacy
potential
toxicity.
When
disrupted,
resulting
imbalance
has
been
linked
a
range
disorders,
such
cancer
cardiovascular
diseases,
highlighting
growing
need
time-sensitive
strategies.
Technological
breakthroughs,
including
wearable
sensors,
digital
health
platforms,
sophisticated
machine
learning
techniques,
now
allow
continuous,
real-time
monitoring
biomarkers,
which
turn
helps
optimize
regimens.
In
oncology,
example,
synchronizing
chemotherapy,
therapy,
immunotherapy
anti-inflammatory
patient’s
cycle
shown
effectiveness
improve
tolerability.
Moreover,
observed
sex-based
differences
responses
emphasize
importance
tailoring
individual
patient
profiles.
Emerging
research
is
focusing
on
directly
targeting
molecular
components,
showing
treating
metabolic
oncological
conditions.
However,
fully
integrating
chronopharmacology
into
clinical
will
require
development
standardized
protocols,
regulatory
backing,
large-scale
trials
that
incorporate
biomarkers.
Ultimately,
merging
biology
strategies
promises
efficacy,
minimize
side
effects,
Future
studies
must
address
inter-individual
variability,
sex
differences,
misalignment
harness
chronotherapy’s
personalized
medicine.
Язык: Английский
Personalization of Cancer Treatment: Exploring the Role of Chronotherapy in Immune Checkpoint Inhibitor Efficacy
Cancers,
Год журнала:
2025,
Номер
17(5), С. 732 - 732
Опубликована: Фев. 21, 2025
In
the
era
of
precision
medicine,
mounting
evidence
suggests
that
time
therapy
administration,
or
chronotherapy,
has
a
great
impact
on
treatment
outcomes.
Chronotherapy
involves
planning
timing
by
considering
circadian
rhythms,
which
are
24
h
oscillations
in
behavior
and
physiology
driven
synchronized
molecular
clocks
throughout
body.
The
value
chronotherapy
cancer
is
currently
under
investigation,
notably
effects
efficacy
side
effects.
Immune
checkpoint
inhibitor
(ICI)
promising
treatment.
However,
many
patients
still
experience
disease
progression
need
to
stop
early
due
There
accumulating
day
at
ICI
administered
can
have
substantial
effect
efficacy.
Thus,
it
important
investigate
intersections
this
review,
we
provide
brief
overview
rhythms
context
immunity
cancer.
Additionally,
outline
current
applications
for
We
synthesize
29
studies
conducted
date
examine
time-of-day
administration
therapy,
its
associated
effects,
sex
differences
both
also
discuss
potential
mechanisms
underlying
these
observed
results.
Finally,
highlight
challenges
area
future
directions
research,
including
chronotherapeutic
personalized
medicine
approach
tailors
individual
patients’
rhythms.
Язык: Английский
Circadian rhythm-based cancer therapy in randomised clinical trials
Expert Review of Anticancer Therapy,
Год журнала:
2023,
Номер
24(1-2), С. 29 - 39
Опубликована: Дек. 21, 2023
Since
the
2017
Nobel
Prize
awarded
to
J.
Hall,
M.
Rosbash
and
M.W.
Young
for
their
discoveries
of
molecular
mechanisms
behind
biological
clock,
circadian
rhythm-based
therapy,
also
known
as
chronotherapy,
is
receiving
more
attention
in
oncology
number
anatomical
sites
interest
this
field
increasing.
This
observation
line
with
clinical
evidence
provided
by
trials
on
head
neck,
lung,
colorectal
cervical
cancers,
well
presently
ongoing
chronotherapy
breast
brain
cancers.
Язык: Английский