Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155619 - 155619
Опубликована: Сен. 28, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(13), С. 7226 - 7226
Опубликована: Июнь 30, 2024
Breast cancer represents the most prevalent form of and leading cause cancer-related mortality among females worldwide. It has been reported that several risk factors contribute to appearance progression this disease. Despite advancements in breast treatment, a significant portion patients with distant metastases still experiences no cure. The extracellular matrix potential target for enhanced serum biomarkers cancer. Furthermore, degradation epithelial–mesenchymal transition constitute primary stages local invasion during tumorigenesis. Additionally, microbiome influence on diverse physiological processes. is emerging microbial dysbiosis element development various cancers, including Thus, better understanding interactions could provide novel alternatives treatment management. In review, we summarize current evidence regarding intricate relationship between microbiome. We discuss arising associations future perspectives field.
Язык: Английский
Процитировано
9
International review of cell and molecular biology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Фев. 6, 2025
Abstract Despite advances in diagnostic and therapeutic strategies, the prognosis of lung squamous cell carcinoma (LUSC) patients remains poor, potential microbiome-based prognostic biomarkers targets largely unexplored. LUSC patient data from The Cancer Genome Atlas (TCGA), including microbial genus level abundance RNA sequencing (RNA-Seq) data, were used as a training dataset. Two other independent datasets GSE19188 GSE157009 serve validation datasets. A risk score (RS) model was constructed by univariate Cox regression analysis combined with least absolute contraction selection operator (LASSO) regression. 18 genera found to be significantly associated RFS patients. signature built these genera, exhibited robust predictive accuracy both Furthermore, hub mRNA between high- low-risk groups selected XGBOOST intersect mRNAs screened analysis, finally identifying four prognosis. This study reveals complex interplay microbiome genetic biomarkers, identifies specific microbial-based LUSC. These findings provide basis for future studies aimed elucidate mechanisms underlying associations guiding treatment decisions improving outcomes.
Язык: Английский
Процитировано
0
Pathogens, Год журнала: 2025, Номер 14(4), С. 355 - 355
Опубликована: Апрель 5, 2025
Antibiotic resistance represents a growing public health threat, with airborne drug-resistant strains being especially alarming due to their ease of transmission and association severe respiratory infections. The microbiome plays pivotal role in maintaining health, influencing the dynamics antibiotic among pathogenic microorganisms. In this context, review proposes exploration complex interplay between microbiota antimicrobial resistance, highlighting implications diversity disease. Moreover, strategies mitigate including stewardship programs, alternatives traditional antibiotics, probiotics, restoration techniques, nanotechnology-based therapeutic interventions, are critically presented, setting an updated framework current management options. Therefore, through better understanding roles alongside emerging strategies, paper aims shed light on how global challenges posed by multi-drug-resistant pathogens can be addressed.
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2025, Номер 6(5)
Опубликована: Апрель 18, 2025
ABSTRACT Dysbiosis refers to the disruption of gut microbiota balance and is pathological basis various diseases. The main pathogenic mechanisms include impaired intestinal mucosal barrier function, inflammation activation, immune dysregulation, metabolic abnormalities. These involve dysfunctions in gut–brain axis, gut–liver others cause broader effects. Although association between diseases caused by dysbiosis has been extensively studied, many questions remain regarding specific treatment strategies. This review begins examining causes summarizes potential representative imbalance. It integrates clinical evidence explore preventive therapeutic strategies targeting emphasizing importance understanding dysbiosis. Finally, we summarized development artificial intelligence (AI) research suggested that it will play a critical role future studies on combining multiomics technologies AI further uncover complex drive personalized
Язык: Английский
Процитировано
0
Translational Cancer Research, Год журнала: 2024, Номер 13(6), С. 3090 - 3105
Опубликована: Июнь 1, 2024
Exosomes are nanoscale extracellular vesicles secreted by cells, which can release bioactive macromolecules, such as microRNA (miRNA) to receptor cells. efficiently penetrate various biological barriers mediate intercellular communication. MiRNA a class of non-coding RNA that primarily regulate messenger (mRNA) at the post-transcriptional level. is abundant in exosomes, plays an important role being transported and released through exosomes lung cancer This review aims elucidate roles exosome-derived miRNAs cancer.
Язык: Английский
Процитировано
2
Cancers, Год журнала: 2024, Номер 16(19), С. 3342 - 3342
Опубликована: Сен. 29, 2024
The past several years have provided a more profound understanding of the role microbial species in lung. respiratory tract is delicate ecosystem bacteria, fungi, parasites, and viruses. Detecting DNA, pathogen-associated molecular patterns (PAMPs), metabolites sputum poised to revolutionize early diagnosis lung cancer. longitudinal monitoring microbiome holds potential predict treatment response side effects, enabling personalized effective options. However, most studies into microbiota been observational not adequately considered impact dietary intake air pollutants. This gap makes it challenging establish direct causal relationship between environmental exposure, changes composition microbiota, carcinogenesis, tumor progression. A holistic that considers both diet pollutants may pave way improved prevention management strategies for
Язык: Английский
Процитировано
2
Nanotechnology Reviews, Год журнала: 2024, Номер 13(1)
Опубликована: Янв. 1, 2024
Graphical abstract
Язык: Английский
Процитировано
1
Pathology - Research and Practice, Год журнала: 2024, Номер 263, С. 155619 - 155619
Опубликована: Сен. 28, 2024
Язык: Английский
Процитировано
0