From chaos to order: optimizing fecal microbiota transplantation for enhanced immune checkpoint inhibitors efficacy
Gut Microbes,
Год журнала:
2025,
Номер
17(1)
Опубликована: Янв. 18, 2025
The
integration
of
fecal
microbiota
transplantation
(FMT)
with
immune
checkpoint
inhibitors
(ICIs)
presents
a
promising
approach
for
enhancing
cancer
treatment
efficacy
and
overcoming
therapeutic
resistance.
This
review
critically
examines
the
controversial
effects
FMT
on
ICIs
outcomes
elucidates
underlying
mechanisms.
We
investigate
how
modulates
gut
composition,
microbial
metabolite
profiles,
tumor
microenvironment,
thereby
influencing
effectiveness.
Key
factors
efficacy,
including
donor
selection
criteria,
recipient
characteristics,
administration
protocols,
are
comprehensively
discussed.
delineates
strategies
optimizing
formulations
systematically
monitoring
post-transplant
microbiome
dynamics.
Through
comprehensive
synthesis
evidence
from
clinical
trials
preclinical
studies,
we
elucidate
potential
benefits
challenges
combining
across
diverse
types.
While
some
studies
report
improved
outcomes,
others
indicate
no
benefit
or
adverse
effects,
emphasizing
complexity
host-microbiome
interactions
in
immunotherapy.
outline
critical
research
directions,
encompassing
need
large-scale,
multi-center
randomized
controlled
trials,
in-depth
ecology
multi-omics
approaches
artificial
intelligence.
Regulatory
ethical
addressed,
underscoring
imperative
standardized
protocols
rigorous
long-term
safety
assessments.
seeks
to
guide
future
endeavors
applications
FMT-ICIs
combination
therapy,
improve
patient
while
ensuring
both
efficacy.
As
this
rapidly
evolving
field
advances,
maintaining
judicious
balance
between
openness
innovation
cautious
scrutiny
is
crucial
realizing
full
modulation
Язык: Английский
Gut microbiota in melanoma: effects and pathogeneses
Microbiological Research,
Год журнала:
2025,
Номер
unknown, С. 128144 - 128144
Опубликована: Март 1, 2025
Язык: Английский
Combination therapy with immune checkpoint inhibitors in colorectal cancer: Challenges, resistance mechanisms, and the role of microbiota
Biomedicine & Pharmacotherapy,
Год журнала:
2025,
Номер
186, С. 118014 - 118014
Опубликована: Март 31, 2025
Язык: Английский
Nature of the Association between Rheumatoid Arthritis and Cervical Cancer and Its Potential Therapeutic Implications
Nutrients,
Год журнала:
2024,
Номер
16(15), С. 2569 - 2569
Опубликована: Авг. 5, 2024
It
is
now
established
that
patients
with
rheumatoid
arthritis
(RA)
have
an
increased
risk
of
developing
cervical
cancer
(CC)
or
its
precursor,
intraepithelial
neoplasia
(CIN).
However,
the
underlying
mechanisms
this
association
not
been
elucidated.
RA
characterized
by
unresolved
chronic
inflammation.
suggested
human
papillomavirus
(HPV)
infection
in
exacerbates
inflammation,
increasing
CC.
The
tumor
microenvironment
CC
also
marked
which
aggravates
manifestations
both
conditions.
Gut
and
vaginal
dysbiosis
are
considered
potential
contribute
to
inflammation
aggravation
manifestations.
Numerous
clinical
pre-clinical
studies
demonstrated
beneficial
effects
various
nutritional
approaches
attenuate
including
polyunsaturated
fatty
acids
their
derivatives,
specialized
pro-resolving
mediators
(SPMs),
probiotics,
prebiotics,
certain
diets.
We
believe
successful
resolution
correction
dysbiosis,
combination
current
anti-RA
anti-CC
therapies,
a
promising
therapeutic
approach
for
This
could
reduce
development
HPV-infected
patients.
Язык: Английский
A two-step, two-sample Mendelian randomization analysis investigating the interplay between gut microbiota, immune cells, and melanoma skin cancer
Medicine,
Год журнала:
2024,
Номер
103(45), С. e40432 - e40432
Опубликована: Ноя. 8, 2024
This
study
aims
to
rigorously
explore
the
potential
causal
relationships
among
gut
microbiota
(GM),
immune
cells,
and
melanoma
skin
cancer
participants
from
Europe,
where
this
disease
exhibits
significant
prevalence
profound
societal
impact.
Using
genome-wide
association
analysis
database,
a
double-sample
Mendelian
randomization
(MR)
was
drawn
upon
investigate
GM,
cancer.
The
inverse
variance
weighted
approach
applied
estimate
connections
these
variables.
A
two-step
MR
employed
quantitatively
gauge
impact
of
cells
mediated
GM
on
To
address
sources
bias,
such
as
pleiotropy
heterogeneity,
multiple
analytical
techniques
were
integrated.
pinpointed
6
taxa
related
either
an
augmented
or
declined
risk
late-stage
In
same
vein,
32
cell
phenotypes
noticed
correlates
with
modified
Our
also
implies
that
probable
between
could
be
facilitated
by
5
phenotypes.
findings
our
underline
certain
influencers
onset
development
Importantly,
results
spotlight
agents
mediating
association.
Язык: Английский