Cellular Signalling, Год журнала: 2025, Номер 128, С. 111632 - 111632
Опубликована: Фев. 6, 2025
Язык: Английский
Cells, Год журнала: 2023, Номер 12(5), С. 729 - 729
Опубликована: Фев. 24, 2023
Abiotic stresses triggered by climate change and human activity cause substantial agricultural environmental problems which hamper plant growth. Plants have evolved sophisticated mechanisms in response to abiotic stresses, such as stress perception, epigenetic modification, regulation of transcription translation. Over the past decade, a large body literature has revealed various regulatory roles long non-coding RNAs (lncRNAs) their irreplaceable functions adaptation. LncRNAs are recognized class ncRNAs that longer than 200 nucleotides, influencing variety biological processes. In this review, we mainly focused on recent progress lncRNAs, outlining features, evolution, lncRNAs drought, low or high temperature, salt, heavy metal stress. The approaches characterize function how they regulate responses were further reviewed. Moreover, discuss accumulating discoveries regarding memory well. present review provides updated information directions for us potential future.
Язык: Английский
Процитировано
49
Non-Coding RNA, Год журнала: 2024, Номер 10(1), С. 13 - 13
Опубликована: Фев. 7, 2024
Plant species utilize a variety of regulatory mechanisms to ensure sustainable productivity. Within this intricate framework, numerous non-coding RNAs (ncRNAs) play crucial role in plant biology, surpassing the essential functions RNA molecules as messengers, ribosomal, and transfer RNAs. ncRNAs represent an emerging class regulators, operating directly form small interfering (siRNAs), microRNAs (miRNAs), long noncoding (lncRNAs), circular (circRNAs). These exert control at various levels, including transcription, post-transcription, translation, epigenetic. Furthermore, they interact with each other, contributing biological processes associated stress resilience. This review primarily concentrates on recent advancements ncRNAs, delineating their growth development across organs such root, leaf, seed/endosperm, seed nutrient development. Additionally, broadens its scope by examining response environmental stresses drought, salt, flood, heat, cold plants. compilation offers updated information insights guide characterization potential growth, development, resilience future research.
Язык: Английский
Процитировано
28
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(8), С. 4124 - 4124
Опубликована: Апрель 8, 2022
Plant growth and development are greatly affected by the environment. Many genes have been identified to be involved in regulating plant adaption of abiotic stress. Apart from protein-coding genes, more evidence indicates that non-coding RNAs (ncRNAs), including small long ncRNAs (lncRNAs), can target developmental stress-responsive mRNAs, regulatory DNA regions, proteins regulate transcription various at transcriptional, posttranscriptional, epigenetic level. Currently, molecular mechanisms sRNAs lncRNAs controlling response being deeply explored. In this review, we summarize recent research progress plants, focusing on signal factors, expression characters, targets functions, interplay network their stress responses. The complex pathways among RNAs, lncRNAs, plants also discussed. Understanding functional implications responses will benefit us regard use as potential character-determining factors breeding.
Язык: Английский
Процитировано
47
International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(16), С. 9301 - 9301
Опубликована: Авг. 18, 2022
During the process of growth and development, plants are prone to various biotic abiotic stresses. They have evolved a variety strategies resist adverse effects these lncRNAs (long non-coding RNAs) type less conserved RNA molecules more than 200 nt (nucleotides) in length. do not code for any protein, but interact with DNA, RNA, protein affect transcriptional, posttranscriptional, epigenetic modulation events. As new regulatory element, play critical role coping environmental pressure during plant development. This article presents comprehensive review on types lncRNAs, mechanism at different molecular levels, coordination between lncRNA miRNA (microRNA) immune responses, latest research progress their response We conclude discussion future direction elaboration function lncRNAs.
Язык: Английский
Процитировано
45
Cellular Oncology, Год журнала: 2023, Номер 46(4), С. 885 - 908
Опубликована: Май 28, 2023
miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of has been reported as hallmark cancer progression, acting an independent prediction marker for individual patient. interplay miRNA lncRNA decides the variation tumorigenesis that could be mediated by sponges endogenous RNAs, regulating decay, mediating intra-chromosomal interactions, modulating epigenetic components. This paper focuses on influence crosstalk between hallmarks such epithelial-mesenchymal transition, hijacking cell death, metastasis, invasion. Other cellular roles crosstalks, neovascularization, vascular mimicry, angiogenesis were also discussed. Additionally, we reviewed mechanism with specific host immune responses targeting (between miRNA) diagnosis management.
Язык: Английский
Процитировано
41
3 Biotech, Год журнала: 2023, Номер 13(3)
Опубликована: Фев. 27, 2023
Язык: Английский
Процитировано
37
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(2), С. 903 - 903
Опубликована: Янв. 11, 2024
Polycystic ovary syndrome (PCOS) is the most common endocrine-metabolic disease in females of reproductive age, affecting 4–20% pre-menopausal women worldwide. MicroRNAs (miRNAs) are endogenous, single-stranded, non-coding, regulatory ribonucleic acid molecules found eukaryotic cells. Abnormal miRNA expression has been associated with several diseases and could possibly explain their underlying pathophysiology. MiRNAs have extensively studied for potential diagnostic, prognostic, therapeutic uses many diseases, such as type 2 diabetes, obesity, cardiovascular disease, PCOS, endometriosis. In miRNAs were to be abnormally expressed theca cells, follicular fluid, granulosa peripheral blood leukocytes, serum, adipose tissue when compared those without making a useful biomarker disease. Key pathways involved folliculogenesis, steroidogenesis, cellular adhesion, regulated by miRNA. This also highlights importance prognostic markers. addition, recent evidence suggests role regulating circadian rhythm (CR). CR crucial reproduction through various functions hypothalamic-pituitary-gonadal (HPG) axis ovaries. A disordered affects outcomes inducing insulin resistance, oxidative stress, systemic inflammation. Moreover, demonstrated interact lncRNA circRNAs, which thought play pathogenesis PCOS. review discusses what currently understood about involved, biomarkers targets.
Язык: Английский
Процитировано
17
Cancers, Год журнала: 2024, Номер 16(1), С. 234 - 234
Опубликована: Янв. 4, 2024
Metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) is a long intergenic non-coding RNA (lncRNA) located on chr11q13. It overexpressed in several cancers and controls gene expression through chromatin modification, transcriptional regulation, post-transcriptional regulation. Importantly, MALAT-1 stimulates cell proliferation, migration, metastasis serves vital role driving the epithelial-to-mesenchymal transition (EMT), subsequently acquiring cancer stem cell-like properties developing drug resistance. modulates EMT by interacting with various intracellular signaling pathways, notably phosphoinositide 3-kinase (PI3K)/Akt Wnt/β-catenin pathways. also behaves like sponge for microRNAs, preventing their interaction target genes promoting EMT. In addition, we have used bioinformatics online tools to highlight disparities of between normal samples using data from The Cancer Genome Atlas (TCGA). Furthermore, intricate interplay essential targets progression renders it good candidate therapeutic interventions. Several innovative approaches been exploited MALAT-1, such as short hairpin RNAs (shRNAs), antisense oligonucleotides (ASOs), natural products. This review emphasizes modulating metastasis, stemness, chemoresistance different cancers.
Язык: Английский
Процитировано
12
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 279, С. 116490 - 116490
Опубликована: Май 24, 2024
With increasing plastic manufacture and consumption, microplastics/nanoplastics (MP/NP) pollution has become one of the world's pressing global environmental issues, which poses significant threats to ecosystems human health. In recent years, sharp researches have confirmed that MP/NP had direct or indirect effects on vegetative growth sexual process vascular plant. But potential mechanisms remain ambiguous. particles can be adsorbed and/or absorbed by plant roots leaves thus cause diverse This holistic review aims discuss plant, with special emphasis changes metabolic molecular levels. alter substance energy metabolism, as well shifts in gene expression patterns. Key aspects affected stress include carbon nitrogen amino acids biosynthesis hormone signal transduction, related genes, metabolism those involved pathogen defense. Additionally, provides updated insights into physiological responses plants exposed MP/NP, encompassing phenomena such seed/spore germination, photosynthesis, oxidative stress, cytotoxicity, genotoxicity. By examining impact from both perspectives, this sets stage for future investigations complex interactions between pollutants.
Язык: Английский
Процитировано
11
Frontiers in Plant Science, Год журнала: 2023, Номер 14
Опубликована: Фев. 15, 2023
Male sterility is classified as either cytoplasmic male (CMS) or genic (GMS). Generally, CMS involves mitochondrial genomes interacting with the nuclear genome, while GMS caused by genes alone. regulated multilevel mechanisms in which non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long (lncRNAs), and phased small interfering (phasiRNAs), have been proven to be critical elements. The development of high-throughput sequencing technology offers new opportunities evaluate genetic mechanism ncRNAs plant sterility. In this review, we summarize that regulate gene expression ways dependent on independent hormones, involve differentiation stamen primordia, degradation tapetum, formation microspores, release pollen. addition, key miRNA–lncRNA–mRNA interaction networks mediating plants are elaborated. We present a different perspective exploring ncRNA-mediated regulatory pathways control create male-sterile lines through hormones genome editing. A refined understanding ncRNA for sterile would conducive improve hybridization breeding.
Язык: Английский
Процитировано
21