Rheumatoid Arthritis and COVID-19 at the Intersection of Immunology and Infectious Diseases: A Related PRISMA Systematic Literature Review

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11149 - 11149

Опубликована: Окт. 17, 2024

Rheumatoid arthritis (RA) patients face different health challenges when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than the general population, due to both their immunocompromised state and immunosuppressive therapies they receive. This systematic literature review, which follows Preferred Reporting Items for Systematic Reviews Meta-Analyses (PRISMA) paradigm, explores interactions between RA SARS-CoV-2 infection, focusing on immunologic issues, disease management, vaccination, adverse outcomes. In order obtain most relevant information, we systematically reviewed specific from 1 January 2021 31 December 2023, based PRISMA method, by eventually selected 35 eligible articles, added other ISI-indexed studies enrich our results further. Consequently, performed a funnel analysis evaluate potential publication bias. Firstly, data collected revealed impact of pandemic diagnoses fear face-to-face medical consultations that delayed adequate treatment. Secondly, cardiovascular metabolic comorbidities increase risk prolonged COVID-19 symptoms, hospitalization, outcomes patients. With respect treatment used control RA, it was observed glucocorticoids (especially high-dose usage) Rituximab (RTX) predispose poor outcomes, as opposed Baricitinib interleukin-6 (IL-6) tumor necrosis factor-alpha (TNF-α) inhibitors. vaccination has proven effective generally safe in some studies, although Methotrexate (MTX), Abatacept (ABA), RTX have been associated impaired vaccine immune response. review brings updated thorough information immunological, clinical, management complex immune-mediated inflammatory (IMID) like setting underlines faced this group The lessons learned can be extended beyond shaping more informed compassionate healthcare system offering long-term care RA.

Язык: Английский

---

COVID and nervous system: Mechanisms and consequences

Elsevier eBooks, Год журнала: 2025, Номер unknown, С. 413 - 435

Опубликована: Янв. 1, 2025

Язык: Английский

---

Significance of Conserved Regions in Coronavirus Spike Protein for Developing a Novel Vaccine against SARS-Cov-2 Infection

Опубликована: Янв. 23, 2023

Abstract: Over the years, several distinct pathogenic coronaviruses have emerged, including pandemic SARS-CoV-2 which is difficult to curtail despite availability of licensed vaccines. The difficulty in managing linked changes variants’ proteins, especially spike protein (S) used for viral entry. These mutations, S, enable virus evade immune responses induced by natural infection or vaccination. However, some parts SP S1 subunit and S2 are considered conserved among coronaviruses. In this review, we will discuss epitopes proteins that been demonstrated various studies be may immunogenic development vaccine. Considering higher conservancy S2, further likely challenges could limit from inducing robust promising approaches increase their immunogenicity.

Язык: Английский

---

Bell's palsy or an aggressive infiltrating basaloid carcinoma post-mRNA vaccination for COVID-19? A case report and review of the literature.

PubMed, Год журнала: 2023, Номер 22, С. 992 - 1011

Опубликована: Янв. 1, 2023

We report on an aggressive, infiltrating, metastatic, and ultimately lethal basaloid type of carcinoma arising shortly after mRNA vaccination for COVID-19. The wife the patient, since deceased, gave consent publishing case. malignancy was cutaneous origin case showed symptoms consistent with Bell's palsy trigeminal neuralgia beginning four days post-vaccination (right side head temporal pain). pain suggestive inflammation impairment T cell immune activation. Magnetic Resonance Imaging (MRI) a vascular loop left lateral aspect 5th cranial root exit cerebellopontine angle constituting presumably normal variant considered as unrelated factor to right-sided that corresponded nerves V (trigeminal nerve) VII (facial nerve). In this study we describe all aspects discuss possible causal links between rapid emergence metastatic cancer vaccination. place within context multiple impairments potentially related injections would be expected potentiate more aggressive presentation progression cancer. suggests population risk occurrence large variety relatively common phenotype cells, which may have potential disease. This can avoidable early diagnosis adequate treatment. Since facial paralysis/pain is one adverse neurological events following injection, careful inspection cutaneous/soft tissue should conducted rule out malignancy. An extensive literature review carried out, in order elucidate toxicity led death patient. Preventive precise routine clinical investigations avoid future mortalities. See also Figure 1(Fig. 1).

Язык: Английский

---

Identifying and profiling structural similarities between Spike of SARS-CoV-2 and other viral or host proteins with Machaon

Communications Biology, Год журнала: 2023, Номер 6(1)

Опубликована: Июль 19, 2023

Using protein structure to predict function, interactions, and evolutionary history is still an open challenge, with existing approaches relying extensively on homology families. Here, we present Machaon, a data-driven method combining orientation invariant metrics phi-psi angles, inter-residue contacts surface complexity. It can be readily applied whole structures or segments-such as domains binding sites. Machaon was SARS-CoV-2 Spike monomers of native, Delta Omicron variants identified correlations wide range viral proteins from close distant taxonomy ranks, well host proteins, such ACE2 receptor. Machaon's meta-analysis the results highlights structural, chemical transcriptional similarities between monomer human indicating multi-level mimicry. This extended analysis also revealed relationships biological processes ubiquitination angiogenesis highlighted different patterns in virus attachment among studied variants. Available at: https://machaonweb.com .

Язык: Английский

---

Shared Pathogenicity Features and Sequences between EBV, SARS-CoV-2, and HLA Class I Molecule-binding Motifs with a Potential Role in Autoimmunity

Clinical Reviews in Allergy & Immunology, Год журнала: 2023, Номер 65(2), С. 206 - 230

Опубликована: Июль 28, 2023

Язык: Английский

---

Molecular Mimicry between SARS-CoV-2 proteins and human self-antigens related with autoimmune central nervous system (CNS) disorders

Опубликована: Окт. 2, 2023

SARS-CoV-2 can trigger autoimmune central nervous system (CNS) diseases in genetically susceptible individuals, a mechanism poorly understood. Molecular mimicry (MM) has been identified other viral as potential triggers of CNS events. This study investigated if MM is the process through which induce breakdown immune tolerance. The frequency disorders was evaluated prospective cohort with patients admitted COVID-19 Intense Care Unity (ICU) Rio de Janeiro. Then, an silico analysis performed to identify conserved regions share high identity between SARS-Cov-2 anti-gens and human proteins. sequences significant antigenic properties were then assessed for their binding capacity HLA subtypes. Of 112 included, 3 classified having disorder. A total eleven combinations had linear three-dimensional overlap. NMDAR1, MOG MPO self-antigens more combinations, followed by GAD65. All presented at least one epitope strong or intermediate subtypes selected. underscores possibility that attacks observed patients, including those our population, could be driven predisposed individuals.

Язык: Английский

---

Impact of COVID-19 on the brain: Antibodies against brain stem antigens

Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 385 - 391

Опубликована: Янв. 1, 2024

Язык: Английский

---

Circulating antibodies to Helicobacter pylori are associated with biomarkers of neurodegeneration in cognitively intact adults

Asian Journal of Psychiatry, Год журнала: 2023, Номер 86, С. 103680 - 103680

Опубликована: Июнь 19, 2023

Язык: Английский

---

Association of Coronavirus Disease 2019 Vaccination with Facial-Related Neurological Disorders: A Nationwide Retrospective Cohort Study

Journal of Personalized Medicine, Год журнала: 2024, Номер 14(7), С. 671 - 671

Опубликована: Июнь 21, 2024

Neurological complications after the coronavirus disease 2019 (COVID-19) vaccine administration have been reported. However, incidence rates of these not compared in vaccinated and unvaccinated individuals. This study used a nationwide cohort from South Korea to investigate prognostic factors facial-related neurological disorders, such as facial palsy, trigeminal neuralgia, hemifacial spasms, COVID-19 vaccination. A population-based design was examine data randomly selected 50% adult population Seoul, Korea. Information on demographics, vaccination status, type, medical history collected. The adjusted hazard ratios (aHRs) for disorders were calculated. included 2,482,481 adults, 85.94% whom vaccinated. Vaccinated individuals showed higher spasm, neuralgia than individuals, with significant aHRs 1.821, 3.203, 6.621, respectively. Dyslipidemia, female sex, young age identified risk spasms neuralgia. demonstrates an increased vaccination, particularly among dyslipidemia younger women. These findings underscore need further investigations into mechanisms management vaccine-related issues.

Язык: Английский

---