Effect of the COVID‐19 pandemic on disease activity in multiple sclerosis patients treated with hematopoietic stem cell transplantation

European Journal of Neurology, Год журнала: 2023, Номер 30(10), С. 3362 - 3366

Опубликована: Июль 22, 2023

It is still debated whether the COVID-19 pandemic affected disease activity in people with autoimmune diseases, including multiple sclerosis (MS). The aim of this study, therefore, was to explore impact MS (pwMS) not receiving continuative disease-modifying therapy (DMT) after previous treatment autologous hematopoietic stem cell transplantation (AHSCT).We included pwMS treated AHSCT who were remission without DMTs during and followed up at our centre study period. Data on SARS-CoV-2 infection vaccination recorded, details adverse events clinical-radiological activity.A total 36 (31 females; 86%) included, whom 23 (64%) had relapsing-remitting (RR-MS) 13 secondary progressive (SP-MS). Thirty-three (92%) received anti-SARS-CoV-2 mRNA vaccines. Thirteen patients (36%) developed mild moderate a median (range) 58 (4-224) months AHSCT; seven (54%) these yet vaccinated. Transient neurological symptoms or reported 9% 36% patients, respectively. rate new inflammatory (relapses asymptomatic magnetic resonance imaging [MRI] activity) increased from 0.006 (one lesion/159 patient-years) before 0.083 (five relapses plus two cases MRI activity/84 since start (p = 0.004).People history highly active disease, are untreated moderate-efficacy might be more vulnerable reactivation, possibly elicited by exogenous triggers. Careful monitoring further investigation warranted ascertain special precautions needed cases.

Язык: Английский

From infection to autoimmunity: ZnT8-mediated molecular mimicry in the triggering of post-COVID 19 type 1 diabetes mellitus

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Сен. 7, 2023

Abstract Introduction The potential etiology of post-COVID-19 type 1 diabetes (DM1) being linked to the development anti-Zinc Transporter 8 antibodies (ZnT8A) through molecular mimicry presents a compelling avenue for investigation, yet there remains notable gap in our understanding this field. While studies have revealed presence these autoantibodies individuals with diabetes, precise mechanisms by which viral infection triggers production anti-ZnT8A are not fully comprehended. Objective To assess between ZnT8 protein and proteins COVID-19 virus, as well its impact on initiation DM1. Methods For study, amino acid sequences were obtained from UniProt databases. Protein structure data acquired Swiss-Model. Multiple sequence alignment using VectorBuilder was performed analyze similarities conserved regions proteins. Pairwise Structure Alignment used three-dimensional Results similarity results follows: 1. ZnT8_HUMAN SPIKE_SARS2: 16.67%; 2. VME1_SARS2: 26.37%; 3. VEMP_SARS2 Envelope small membrane protein: 11.26%; 4. A0A883GPN5_SARS2 Nucleoprotein: 32.94%. Conclusion Based obtained, it can be concluded that is level important certain virus. These findings provide insights into trigger

Язык: Английский