Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 7, 2023
Abstract
Introduction
The
potential
etiology
of
post-COVID-19
type
1
diabetes
(DM1)
being
linked
to
the
development
anti-Zinc
Transporter
8
antibodies
(ZnT8A)
through
molecular
mimicry
presents
a
compelling
avenue
for
investigation,
yet
there
remains
notable
gap
in
our
understanding
this
field.
While
studies
have
revealed
presence
these
autoantibodies
individuals
with
diabetes,
precise
mechanisms
by
which
viral
infection
triggers
production
anti-ZnT8A
are
not
fully
comprehended.
Objective
To
assess
between
ZnT8
protein
and
proteins
COVID-19
virus,
as
well
its
impact
on
initiation
DM1.
Methods
For
study,
amino
acid
sequences
were
obtained
from
UniProt
databases.
Protein
structure
data
acquired
Swiss-Model.
Multiple
sequence
alignment
using
VectorBuilder
was
performed
analyze
similarities
conserved
regions
proteins.
Pairwise
Structure
Alignment
used
three-dimensional
Results
similarity
results
follows:
1.
ZnT8_HUMAN
SPIKE_SARS2:
16.67%;
2.
VME1_SARS2:
26.37%;
3.
VEMP_SARS2
Envelope
small
membrane
protein:
11.26%;
4.
A0A883GPN5_SARS2
Nucleoprotein:
32.94%.
Conclusion
Based
obtained,
it
can
be
concluded
that
is
level
important
certain
virus.
These
findings
provide
insights
into
trigger
European Journal of Neurology,
Год журнала:
2023,
Номер
30(10), С. 3362 - 3366
Опубликована: Июль 22, 2023
It
is
still
debated
whether
the
COVID-19
pandemic
affected
disease
activity
in
people
with
autoimmune
diseases,
including
multiple
sclerosis
(MS).
The
aim
of
this
study,
therefore,
was
to
explore
impact
MS
(pwMS)
not
receiving
continuative
disease-modifying
therapy
(DMT)
after
previous
treatment
autologous
hematopoietic
stem
cell
transplantation
(AHSCT).We
included
pwMS
treated
AHSCT
who
were
remission
without
DMTs
during
and
followed
up
at
our
centre
study
period.
Data
on
SARS-CoV-2
infection
vaccination
recorded,
details
adverse
events
clinical-radiological
activity.A
total
36
(31
females;
86%)
included,
whom
23
(64%)
had
relapsing-remitting
(RR-MS)
13
secondary
progressive
(SP-MS).
Thirty-three
(92%)
received
anti-SARS-CoV-2
mRNA
vaccines.
Thirteen
patients
(36%)
developed
mild
moderate
a
median
(range)
58
(4-224)
months
AHSCT;
seven
(54%)
these
yet
vaccinated.
Transient
neurological
symptoms
or
reported
9%
36%
patients,
respectively.
rate
new
inflammatory
(relapses
asymptomatic
magnetic
resonance
imaging
[MRI]
activity)
increased
from
0.006
(one
lesion/159
patient-years)
before
0.083
(five
relapses
plus
two
cases
MRI
activity/84
since
start
(p
=
0.004).People
history
highly
active
disease,
are
untreated
moderate-efficacy
might
be
more
vulnerable
reactivation,
possibly
elicited
by
exogenous
triggers.
Careful
monitoring
further
investigation
warranted
ascertain
special
precautions
needed
cases.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Сен. 7, 2023
Abstract
Introduction
The
potential
etiology
of
post-COVID-19
type
1
diabetes
(DM1)
being
linked
to
the
development
anti-Zinc
Transporter
8
antibodies
(ZnT8A)
through
molecular
mimicry
presents
a
compelling
avenue
for
investigation,
yet
there
remains
notable
gap
in
our
understanding
this
field.
While
studies
have
revealed
presence
these
autoantibodies
individuals
with
diabetes,
precise
mechanisms
by
which
viral
infection
triggers
production
anti-ZnT8A
are
not
fully
comprehended.
Objective
To
assess
between
ZnT8
protein
and
proteins
COVID-19
virus,
as
well
its
impact
on
initiation
DM1.
Methods
For
study,
amino
acid
sequences
were
obtained
from
UniProt
databases.
Protein
structure
data
acquired
Swiss-Model.
Multiple
sequence
alignment
using
VectorBuilder
was
performed
analyze
similarities
conserved
regions
proteins.
Pairwise
Structure
Alignment
used
three-dimensional
Results
similarity
results
follows:
1.
ZnT8_HUMAN
SPIKE_SARS2:
16.67%;
2.
VME1_SARS2:
26.37%;
3.
VEMP_SARS2
Envelope
small
membrane
protein:
11.26%;
4.
A0A883GPN5_SARS2
Nucleoprotein:
32.94%.
Conclusion
Based
obtained,
it
can
be
concluded
that
is
level
important
certain
virus.
These
findings
provide
insights
into
trigger