Special Issue “Computer-Aided Drug Discovery and Treatment”

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2683 - 2683

Опубликована: Фев. 26, 2024

This Special Issue aims to highlight some of the latest developments in drug discovery [...].

Язык: Английский

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Free Will as Defined by the Constrained Disorder Principle: a Restricted, Mandatory, Personalized, Regulated Process for Decision-Making

Integrative Psychological and Behavioral Science, Год журнала: 2024, Номер unknown

Опубликована: Июнь 20, 2024

Abstract The concept of free will has challenged physicists, biologists, philosophers, and other professionals for decades. constrained disorder principle (CDP) is a fundamental law that defines systems according to their inherent variability. It provides mechanisms adapting dynamic environments. This work examines the CDP's perspective concerning various theories. Per CDP, lack intentions, "freedom" select act built into design. embedded within response range determined by boundaries systems' built-in self-generating mechanism enables cope with perturbations. According neither dualism nor an unknown metaphysical apparatus dictates choices. Brain variability facilitates cognitive adaptation complex, unpredictable situations across Human behaviors decisions reflect underlying physical in brain organs dealing noises. Choices are not predetermined but ongoing processes prssu½res. Malfunctions disease states characterized inappropriate variability, reflecting inability respond adequately Incorporating CDP-based interventions can overcome malfunctions improve decision processes. second-generation artificial intelligence platforms being evaluated augment personal development, wellness, health.

Язык: Английский

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Harnessing Variability Signatures and Biological Noise May Enhance Immunotherapies’ Efficacy and Act as Novel Biomarkers for Diagnosing and Monitoring Immune-Associated Disorders

ImmunoTargets and Therapy, Год журнала: 2024, Номер Volume 13, С. 525 - 539

Опубликована: Окт. 1, 2024

Lack of response to immunotherapies poses a significant challenge in treating immune-mediated disorders and cancers. While the mechanisms associated with poor responsiveness are not well defined change between among subjects, current methods for overcoming loss insufficient. The Constrained Disorder Principle (CDP) explains biological systems based on their inherent variability, bounded by dynamic boundaries that internal external perturbations. Inter intra-subject variability characterize immune system, making it difficult provide single therapeutic regimen all patients even same over time. dynamicity is also personalizing immunotherapies. CDP-based second-generation artificial intelligence system an outcome-based platform incorporates personalized signatures into may improving treatments. offer method identifying new biomarkers early diagnosis, monitoring immune-related disorders, evaluating

Язык: Английский

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Improving the effectiveness of anti-aging modalities by using the constrained disorder principle-based management algorithms

Frontiers in Aging, Год журнала: 2022, Номер 3

Опубликована: Дек. 14, 2022

Aging is a complex biological process with multifactorial nature underlined by genetic, environmental, and social factors. In the present paper, we review several mechanisms of aging pre-clinically clinically studied anti-aging therapies. Variability characterizes processes from genome to cellular organelles, biochemical processes, whole organs’ function. associated alterations in degrees variability complexity systems. The constrained disorder principle defines living organisms based on their inherent within arbitrary boundaries as having lower or moving outside variability. We focus associations between hallmarks discuss roles systems pathogenesis aging. paper presents concept implementing disease principle-based second-generation artificial intelligence for improving modalities. platform uses noise enhance systems’ efficiency slow process. Described potential use patients chronic its implications aged population.

Язык: Английский

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Inter-organ correlations in inflammation regulation: a novel biological paradigm in a murine model

Journal of Medicine and Life, Год журнала: 2025, Номер 18(1), С. 67 - 72

Опубликована: Янв. 1, 2025

Interactions between immune system constituents are mediated through direct contact or the transfer of mediators. The study aimed to assess correlation components and out-of-body signals in a model liver inflammation. In first experiment, mice injected with Concanavalin A (ConA) were housed cage tube on top containing healthy livers harvested from ConA. second that contained splenocytes naïve donors treated vitro dexamethasone. Mice tested for serum aspartate aminotransferase (AST) alanine (ALT) levels. External whole spleens influenced immune-mediated inflammatory response mice. When ConA-injected cages tubes mice, ALT levels significantly reduced. elevated when kept part ConA had increased Similarly, dexamethasone-treated also showed data suggest correlations can be established using without

Язык: Английский

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The Constrained Disorder Principle: Beyond Biological Allostasis

Biology, Год журнала: 2025, Номер 14(4), С. 339 - 339

Опубликована: Март 25, 2025

The constrained disorder principle (CDP) defines complex biological systems based on inherent variability. Allostasis refers to the physiological processes that help maintain stability in response changing environmental demands. Allostatic load describes cumulative wear and tear body resulting from prolonged exposure stress, it has been suggested mediate relationship between stress disease. This study presents concepts of CDP allostasis while discussing their similarities differences. We reviewed current literature potential benefits introducing controlled doses noise into interventions, which may enhance effectiveness therapies. paper highlights promising role variability provided by a CDP-based second-generation artificial intelligence system improving health outcomes.

Язык: Английский

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The Relationship Between Biological Noise and Its Application: Understanding System Failures and Suggesting a Method to Enhance Functionality Based on the Constrained Disorder Principle

Biology, Год журнала: 2025, Номер 14(4), С. 349 - 349

Опубликована: Март 27, 2025

The Constrained Disorder Principle (CDP) offers a new framework for understanding how biological systems use and manage noise to maintain optimal functionality. This review explores the relationship between at various scales, including genetic, cellular, organ levels, its implications system malfunctions. According CDP, all require an range of function appropriately, disease states can arise when these levels are disrupted. presents evidence supporting this principle across different contexts, such as genetic variability, cellular behavior, brain functions, human aging, evolution, drug administration. For accurate clinical assessments, it is essential distinguish technical variability intrinsic variability. When adequately constrained, serves fundamental mechanism adaptation functioning rather than simply source disruption. These findings have important developing more effective therapeutic strategies systems’ dynamics. CDP-based second-generation artificial intelligence help regulate address improved outcomes in conditions by incorporating controlled randomness. Understanding patterns has significant diagnosis, treatment monitoring, development medical conditions.

Язык: Английский

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The constrained disorder principle and the law of increasing functional information: The elephant versus the Moeritherium

Deleted Journal, Год журнала: 2025, Номер unknown, С. 100040 - 100040

Опубликована: Апрель 1, 2025

Язык: Английский

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The Constrained Disorder Principle Accounts for the Variability That Characterizes Breathing: A Method for Treating Chronic Respiratory Diseases and Improving Mechanical Ventilation

Advances in respiratory medicine, Год журнала: 2023, Номер 91(5), С. 350 - 367

Опубликована: Сен. 9, 2023

Variability characterizes breathing, cellular respiration, and the underlying quantum effects. serves as a mechanism for coping with changing environments; however, this hypothesis does not explain why many of variable phenomena respiration manifest randomness. According to constrained disorder principle (CDP), living organisms are defined by their inherent bounded boundaries. The present paper describes mechanisms breathing focusing on variability. It defines how CDP accounts variability randomness in respiration. also provides scheme potential role energy balance biological systems. option using CDP-based artificial intelligence platforms augment respiratory process's efficiency, correct malfunctions, treat disorders associated system.

Язык: Английский

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Using the Constrained Disorder Principle to Navigate Uncertainties in Biology and Medicine: Refining Fuzzy Algorithms

Biology, Год журнала: 2024, Номер 13(10), С. 830 - 830

Опубликована: Окт. 16, 2024

Uncertainty in biology refers to situations which information is imperfect or unknown. Variability, on the other hand, measured by frequency distribution of observed data. Biological variability adds uncertainty. The Constrained Disorder Principle (CDP) defines all systems universe their inherent variability. According CDP, exhibit a degree necessary for proper function, allowing them adapt changes environments. Per while differs from uncertainty, it can be viewed as regulated mechanism efficient functionality rather than This paper explores various aspects un-certainties biology. It focuses using CDP-based platforms refining fuzzy algorithms address some challenges associated with biological and medical uncertainties. Developing decision tree that considers natural help minimize method reveal previously unidentified classes, reduce number unknowns, improve accuracy modeling results, generate algorithm outputs are more biologically clinically relevant.

Язык: Английский

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