Advancements in liposomal formulations: A comprehensive exploration of industrial production techniques
International Journal of Pharmaceutics,
Год журнала:
2024,
Номер
658, С. 124212 - 124212
Опубликована: Май 8, 2024
Язык: Английский
Advancements in 5-fluorouracil-Loaded liposomal nanosystems: A comprehensive review on recent innovations in nanomedicine for cancer therapy
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
96, С. 105730 - 105730
Опубликована: Апрель 28, 2024
Язык: Английский
Optimized green synthesis of silver nanoparticles from guarana seed skin extract with antibacterial potential
Green Processing and Synthesis,
Год журнала:
2025,
Номер
14(1)
Опубликована: Янв. 1, 2025
Abstract
This
study
optimizes
the
green
synthesis
of
silver
nanoparticles
(AgNPs)
using
seed
skin
extract
guarana
(
Paullinia
cupana
)
as
a
natural
stabilizing
and
reducing
agent.
Employing
Taguchi
design,
nine
experiments
were
conducted
across
three
levels
for
four
key
factors:
reaction
temperature,
pH,
nitrate
concentration,
concentration
to
minimize
AgNP
size.
Optimal
conditions
–
pH
11,
5
mM
nitrate,
50°C
1%
(m/v)
produced
quasi-spherical
AgNPs
with
an
average
size
∼26
nm.
Chemical
analysis
revealed
caffeine
main
organic
compound
potassium
oxide
primary
inorganic
component.
UV-vis
spectra
showed
absorption
peak
at
438
nm,
X-ray
diffraction
confirmed
typical
peaks.
Further
identified
polyphenols,
alkaloids,
flavonoids
agents.
A
high
(180.0
±
0.2
ppm)
was
through
ICP-OES,
demonstrated
significant
antibacterial
activity
against
Escherichia
coli
Staphylococcus
aureus
,
minimum
inhibitory
50
μg·mL
−1
.
underscores
sustainability
promising
alternative
traditional
nanoparticle
production
methods.
Язык: Английский
Preparation of Nanoliposomes Containing Rosemary Alcoholic Extract with Polyethylene Glycol Coating
Journal of Arak University of Medical Sciences,
Год журнала:
2025,
Номер
27(6), С. 363 - 369
Опубликована: Янв. 1, 2025
Язык: Английский
Physicochemical stability, antioxidant and ACE-inhibitory activities of cryoprotected liposomes encapsulating stone fish-derived peptides
Applied Food Research,
Год журнала:
2025,
Номер
unknown, С. 100906 - 100906
Опубликована: Апрель 1, 2025
Язык: Английский
Understanding the zeta potential of nanomaterials through predictive nanoinformatics
Nano Today,
Год журнала:
2025,
Номер
64, С. 102783 - 102783
Опубликована: Май 8, 2025
Язык: Английский
Transgenic zebrafish embryos to evaluate the in vivo effects of different liposome-paclitaxel nanocarrier system
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 26, 2025
Zebrafish
is
an
established
valuable
model
for
understanding
the
complex
in
vivo
behavior
of
systemic
nanocarrier
strategies,
their
safety
profile,
and
array
possible
compositions.
To
date,
we
have
explored
possibility
Paclitaxel
(PTX)
delivery
using
liposome
systems
as
a
promising
approach
to
treating
cancer.
Despite
its
benefits,
this
efficacious
anti-cancer
drug
presents
main
adverse
effect,
such
onset
chemotherapy-induced
peripheral
neuropathy
(CIPN).
Thus,
many
research
efforts
are
aimed
at
searching
resolution
or
reduction
problems.
Taking
advantage
zebrafish
embryos,
powerful
predicting
translating
what
observed
humans,
investigated
plain
PTX
outcomes
compared
them
effects
different
liposomes
loaded
with
PTX.
Since
approximately
70%
human
genes
least
one
orthologue
zebrafish,
studying
molecular
mechanisms
underlying
toxicity
increased
oxidative
stress
becomes
easy.
First,
used
transgenic
evaluate
response
concentrations
PTX,
planning
final
concentration
be
liposomes,
without
functionalization.
Then,
assessed
system
molecular,
histochemical,
behavioral
level
reducing
detrimental
side
most
successful
cancer
drug.
Язык: Английский
Using the vector of the ideality of correlation to simulate the zeta potential of nanoparticles under different experimental conditions, represented by quasi-SMILES
Structural Chemistry,
Год журнала:
2024,
Номер
35(6), С. 1925 - 1935
Опубликована: Июнь 28, 2024
Язык: Английский
Structure-function relationships in the modification of liposomes for targeted drug delivery in infectious diseases
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 5, 2024
The
introduction
of
liposomes
has
caused
a
paradigm
shift
in
medicine,
offering
novel
solutions
to
problems
that
are
ancient
the
drug
discovery
and
development
for
HIV,
TB,
malaria.
These
three
deadliest
infectious
diseases
endowed
with
complex
pathophysiological
biological
mechanisms
allow
them
thrive
their
hosts
through
escaping
immune
system
capturing
key
pathways.
Disease
heterogeneity
lack
suitable
models
replicate
disease
states
make
compounds
poor
pharmacokinetic
issues
associated
these
diseases.
Liposomes
lipid-based
nanocarriers
employed
formulations,
preservation,
storage.
Importantly,
they
can
be
tailored
targeted
controlled
release.
Structure–function
relationships
crucial
consider
liposome
design
as
affect
interactions
between
carrier
target
cell,
which
impact
on
release,
cellular
uptake,
bioavailability,
biodistribution,
toxicity.
Herein,
lipid
composition,
size,
lamellarity,
zeta
potential/charge
well
surface
modification
cholesterol,
PEG,
peptides,
antibodies
discussed
respect
selectivity
targeting
diseased
cells.
role
computational
tools
expediting
technology
is
reviewed,
highlighting
forces
interaction
biomolecules
conditions
environment.
Язык: Английский
Preparation and Characterization of Ozonated Liposomes Loaded with Curcumin: A Potential Approach for Diabetic Retinopathy Treatment
Jundishapur Journal of Natural Pharmaceutical Products,
Год журнала:
2024,
Номер
19(4)
Опубликована: Ноя. 10, 2024
Background:
Limitations
in
drug
penetration
are
overcome
by
nanotechnology,
particularly
liposomes,
which
enhance
targeted
administration
of
ocular
medications.
Liposomes
can
augment
the
therapeutic
effects
curcumin,
a
natural
compound
with
positive
impacts
on
retina.
Treatments
for
eye
diseases
also
benefit
from
antibacterial
properties
ozonated
oil
liposomes.
Objectives:
This
study
aims
to
develop
and
evaluate
liposomes
loaded
curcumin
delivery
applications,
specifically
targeting
diabetic
retinopathy
(DR).
Methods:
Liposomal
nanoparticles
were
prepared
using
thin-film
hydration,
incorporating
phospholipids,
lecithin,
cholesterol,
oil,
curcumin.
We
assessed
physicochemical
including
particle
size,
zeta
potential,
encapsulation
efficiency
(EE),
morphology.
Drug
release
profiles
stability
studies
conducted.
Results:
The
optimized
showed
size
84.77
nm,
potential
-16.8
mV,
an
EE
94.73%.
formulation
exhibited
sustained
over
24
hours,
reaching
82.09%
cumulative
release.
Stability
indicated
minimal
changes
key
parameters
three
months
at
room
temperature.
Conclusions:
developed
liposomal
demonstrates
promising
characteristics
delivery,
potentially
enhancing
its
efficacy
DR.
Язык: Английский