Unraveling diversity by isolating peptide sequences specific to distinct taxonomic groups DOI Creative Commons
Eleftherios Bochalis,

Michail Patsakis,

Nikol Chantzi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Abstract The identification of succinct, universal fingerprints that enable the characterization individual taxonomies can reveal insights into trait development and have widespread applications in pathogen diagnostics, human healthcare, ecology biomes. Here, we investigated existence peptide k-mer sequences are exclusively present a specific taxonomy absent every other taxonomic level, termed quasi-primes. By analyzing proteomes across 24,073 species, identified quasi-prime peptides to superkingdoms, kingdoms, phyla, uncovering their distributions functional relevance. These exhibit remarkable sequence uniqueness at six- seven-amino- acid lengths, offering evolutionary divergence lineage-specific adaptations. Moreover, show loci more prone harboring pathogenic variants, underscoring significance. This study introduces quasi-primes offers contributions proteomic diversity, pathways, adaptations tree life, while emphasizing potential impact on health disease.

Язык: Английский

A Survey of K-mer Methods and Applications in Bioinformatics DOI Creative Commons
Camille Moeckel, Manvita Mareboina, Maxwell A. Konnaris

и другие.

Computational and Structural Biotechnology Journal, Год журнала: 2024, Номер 23, С. 2289 - 2303

Опубликована: Май 21, 2024

The rapid progression of genomics and proteomics has been driven by the advent advanced sequencing technologies, large, diverse, readily available omics datasets, evolution computational data processing capabilities. vast amount generated these advancements necessitates efficient algorithms to extract meaningful information. K-mers serve as a valuable tool when working with large offering several advantages in speed memory efficiency carrying potential for intrinsic biological functionality. This review provides an overview methods, applications, significance k-mers genomic proteomic analyses, well utility absent sequences, including nullomers nullpeptides, disease detection, vaccine development, therapeutics, forensic science. Therefore, highlights pivotal role addressing current problems underscores their future breakthroughs research.

Язык: Английский

Процитировано

26
Unraveling diversity by isolating peptide sequences specific to distinct taxonomic groups DOI Creative Commons
Eleftherios Bochalis,

Michail Patsakis,

Nikol Chantzi

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Abstract The identification of succinct, universal fingerprints that enable the characterization individual taxonomies can reveal insights into trait development and have widespread applications in pathogen diagnostics, human healthcare, ecology biomes. Here, we investigated existence peptide k-mer sequences are exclusively present a specific taxonomy absent every other taxonomic level, termed quasi-primes. By analyzing proteomes across 24,073 species, identified quasi-prime peptides to superkingdoms, kingdoms, phyla, uncovering their distributions functional relevance. These exhibit remarkable sequence uniqueness at six- seven-amino- acid lengths, offering evolutionary divergence lineage-specific adaptations. Moreover, show loci more prone harboring pathogenic variants, underscoring significance. This study introduces quasi-primes offers contributions proteomic diversity, pathways, adaptations tree life, while emphasizing potential impact on health disease.

Язык: Английский

Процитировано

0