Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking DOI Creative Commons

Ruiting Ma,

Wenjing Zhang, Lixia Chen

и другие.

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Июнь 6, 2025

Depression is a prevalent and debilitating neuropsychiatric disorder, often associated with neuroinflammation, oxidative stress, neuronal apoptosis. Jiawei Suanzaoren (JWSZR), traditional Chinese medicine (TCM) formulation, has demonstrated potential in alleviating depressive symptoms. However, its precise molecular mechanisms remain unclear. This study aims to elucidate the neuroprotective effects of JWSZR depression using network pharmacology, docking, vitro experimental validation. Active compounds were identified TCMSP HERB databases, depression-related targets retrieved from GeneCards, DisGeNET, OMIM. A protein-protein interaction (PPI) was constructed, followed by functional enrichment analyses, including Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathways. Molecular docking employed predict interactions between JWSZR's active components key target proteins. Furthermore, experiments performed corticosterone (CORT)-induced PC12 cell model validate JWSZR, assessing viability apoptosis rates. Network pharmacology revealed that exerts through multiple targets, estrogen receptor ESR2, HSP90AA1, STAT1. These regulate immune responses, inflammatory pathways, survival. In vitro, significantly improved reduced CORT-treated cells, indicating protect against neurodegeneration. provides novel insights into depression, suggesting it may act multi-target involving modulation inhibition.

Язык: Английский

Identification of novel biomarkers associated with immune infiltration in major depression disorder and atopic dermatitis DOI
Han Jiang,

Bizhen Gong,

Z.-Q. Yan

и другие.

Archives of Dermatological Research, Год журнала: 2025, Номер 317(1)

Опубликована: Фев. 15, 2025

Язык: Английский

Процитировано

0
Exploring potential diagnostic markers and therapeutic targets for type 2 diabetes mellitus with major depressive disorder through bioinformatics and in vivo experiments DOI Creative Commons
Yikai Zhang, Li‐Ling Wu,

Caixia Zheng

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 15, 2025

Type 2 diabetes mellitus (T2DM) and Major depressive disorder (MDD) act as risk factors for each other, the comorbidity of both significantly increases all-cause mortality rate. Therefore, studying diagnosis treatment with depression (DD) is great significance. In this study, we progressively identified hub genes associated T2DM through WGCNA analysis, PPI networks, machine learning, constructed ROC nomogram to assess their diagnostic efficacy. Additionally, validated these using qRT-PCR in hippocampus DD model mice. The results indicate that UBTD1, ANKRD9, CNN2, AKT1, CAPZA2 are shared depression, CNN2 UBTD1 demonstrating favorable predictive model, (p > 0.05) ANKRD9 < 0.01) were downregulated, while 0.001), AKT1 0.05), upregulated. We have discussed mechanisms action pathogenesis therapy DD, suggesting therapeutic potential, propose may serve prospective candidates DD. conclusion, work offers new insights future research on

Язык: Английский

Процитировано

0
Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson’s Disease DOI

Md Touki Tahamid Tusar,

Md Masudur Rahman Munna,

Md Hossain Ahmed

и другие.

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Июнь 4, 2025

Язык: Английский

Процитировано

0
Exploring the neuroprotective mechanisms of Jiawei Suanzaoren decoction in depression: insights from network pharmacology and molecular docking DOI Creative Commons

Ruiting Ma,

Wenjing Zhang, Lixia Chen

и другие.

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Июнь 6, 2025

Depression is a prevalent and debilitating neuropsychiatric disorder, often associated with neuroinflammation, oxidative stress, neuronal apoptosis. Jiawei Suanzaoren (JWSZR), traditional Chinese medicine (TCM) formulation, has demonstrated potential in alleviating depressive symptoms. However, its precise molecular mechanisms remain unclear. This study aims to elucidate the neuroprotective effects of JWSZR depression using network pharmacology, docking, vitro experimental validation. Active compounds were identified TCMSP HERB databases, depression-related targets retrieved from GeneCards, DisGeNET, OMIM. A protein-protein interaction (PPI) was constructed, followed by functional enrichment analyses, including Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathways. Molecular docking employed predict interactions between JWSZR's active components key target proteins. Furthermore, experiments performed corticosterone (CORT)-induced PC12 cell model validate JWSZR, assessing viability apoptosis rates. Network pharmacology revealed that exerts through multiple targets, estrogen receptor ESR2, HSP90AA1, STAT1. These regulate immune responses, inflammatory pathways, survival. In vitro, significantly improved reduced CORT-treated cells, indicating protect against neurodegeneration. provides novel insights into depression, suggesting it may act multi-target involving modulation inhibition.

Язык: Английский

Процитировано

0