The silent spread: exploring diverse metastatic pathways in high-grade serous ovarian cancer DOI Creative Commons
Mengqi Deng,

Ruiye Yang,

Junyi Jiang

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 5, 2025

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and deadly gynecological cancer, with metastasis being key factor in its poor prognosis. Historically, HGSOC was thought to spread primarily through the peritoneal cavity, but recent research has revealed additional routes of metastasis, including blood lymphatic systems. This review discusses complex processes focusing on immune suppression, stromal reprogramming, role circulating tumor cells blood-based spread. We also explore clinical significance particularly impact patient outcomes. Gaining insight into molecular genetic drivers, such as BRCA mutations interactions within microenvironment, essential for developing targeted treatments. Future studies should aim enhance experimental models, identify early detection markers, investigate novel therapeutic approaches effectively address improve survival.

Язык: Английский

Functional tumor-derived exosomes in NSCLC progression and clinical implications DOI Creative Commons
Yuxin Gao, Jun Xie,

Zhenya Yang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases and remains one the leading causes cancer-related mortality worldwide. The high rate is primarily driven by delayed diagnosis, rapid metastasis, frequent recurrence. Tumor-derived exosomes (TEXs) have emerged as critical mediators in NSCLC progression, offering valuable insights into tumor microenvironment. Exosomes are small membrane vesicles that facilitate intercellular communication transport bioactive molecules, including proteins, RNAs, DNAs, thereby reflecting genetic complexity tumors. These play a key role promoting epithelial-mesenchymal transition (EMT), neovascularization, drug resistance, immune evasion, which pivotal development NSCLC. This review explores diverse roles TEXs focusing on their involvement pre-metastatic niche formation, tissue modulation. Specifically, we discuss exosome-associated RNAs proteins NSCLC, contribute to growth metastasis. Furthermore, explore potential biomarkers emphasizing application prognosis, prediction resistance targeted therapies immunotherapies.

Язык: Английский

Процитировано

1
The silent spread: exploring diverse metastatic pathways in high-grade serous ovarian cancer DOI Creative Commons
Mengqi Deng,

Ruiye Yang,

Junyi Jiang

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 5, 2025

High-grade serous ovarian cancer (HGSOC) is a highly aggressive and deadly gynecological cancer, with metastasis being key factor in its poor prognosis. Historically, HGSOC was thought to spread primarily through the peritoneal cavity, but recent research has revealed additional routes of metastasis, including blood lymphatic systems. This review discusses complex processes focusing on immune suppression, stromal reprogramming, role circulating tumor cells blood-based spread. We also explore clinical significance particularly impact patient outcomes. Gaining insight into molecular genetic drivers, such as BRCA mutations interactions within microenvironment, essential for developing targeted treatments. Future studies should aim enhance experimental models, identify early detection markers, investigate novel therapeutic approaches effectively address improve survival.

Язык: Английский

Процитировано

0