bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Апрель 18, 2025
Layers composed of lateral connections prevail in biological systems from subcellular membranes to epithelial sheets. This work presents a continuum framework describe the effects mechanical forces within 3D curved layer with supporting mesh. We provide detailed discussion on emergence stress anisotropy as function depth different curvature settings, building Lou et al. Phys. Rev. Lett. 130 , 108401 (2023). principally consider an monolayer explain how interplay between and cell mechanics determines anisotropy. show that this can lead irregular cellular shapes 3D, including scutoid-like geometries. Our is general, be extended diverse set biologically relevant systems.
Язык: Английский