Physiologia, Год журнала: 2024, Номер 4(4), С. 517 - 567
Опубликована: Дек. 16, 2024
The pervasive presence of per- and polyfluoroalkyl substances (PFAS) in the environment their persistent nature raise significant concerns regarding impact on human health. This review delves into obesogenic potential PFAS, shedding light mechanisms action, epidemiological correlations with obesity metabolic disorders, challenges faced regulatory frameworks. characterized by carbon-fluorine chains, are ubiquitous various consumer products, leading to widespread exposure through ingestion contaminated food water. Emerging evidence suggests that PFAS may act as endocrine-disrupting chemicals, interfering lipid metabolism hormone functions related obesity. We examine vitro, vivo, human, silico studies explore interaction PPARs other molecular targets, influencing adipogenesis homeostasis. Furthermore, highlights investigating association between maternal risk offspring, presenting mixed inconclusive findings underscore complexity effects Presently, there major studying toxicity, including chemical diversity limitations current guidelines, remediation, detoxification. emphasizes need for a multidisciplinary approach, combining advanced analytical methods, models, comprehensive studies, unravel inform effective public health strategies.
Язык: Английский