Physiologia,
Год журнала:
2024,
Номер
4(4), С. 517 - 567
Опубликована: Дек. 16, 2024
The
pervasive
presence
of
per-
and
polyfluoroalkyl
substances
(PFAS)
in
the
environment
their
persistent
nature
raise
significant
concerns
regarding
impact
on
human
health.
This
review
delves
into
obesogenic
potential
PFAS,
shedding
light
mechanisms
action,
epidemiological
correlations
with
obesity
metabolic
disorders,
challenges
faced
regulatory
frameworks.
characterized
by
carbon-fluorine
chains,
are
ubiquitous
various
consumer
products,
leading
to
widespread
exposure
through
ingestion
contaminated
food
water.
Emerging
evidence
suggests
that
PFAS
may
act
as
endocrine-disrupting
chemicals,
interfering
lipid
metabolism
hormone
functions
related
obesity.
We
examine
vitro,
vivo,
human,
silico
studies
explore
interaction
PPARs
other
molecular
targets,
influencing
adipogenesis
homeostasis.
Furthermore,
highlights
investigating
association
between
maternal
risk
offspring,
presenting
mixed
inconclusive
findings
underscore
complexity
effects
Presently,
there
major
studying
toxicity,
including
chemical
diversity
limitations
current
guidelines,
remediation,
detoxification.
emphasizes
need
for
a
multidisciplinary
approach,
combining
advanced
analytical
methods,
models,
comprehensive
studies,
unravel
inform
effective
public
health
strategies.
ACS ES&T Engineering,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 22, 2024
Per-
and
polyfluoroalkyl
substances
(PFAS),
persistent
pollutants
found
in
water
sources
worldwide,
pose
significant
challenges
to
conventional
remediation
methods.
This
study
presents
a
one-pot,
high
atom-economy
synthesis
of
porphyrin-based
cationic
nanocages
(oNCs)
as
selective,
rapid
efficient
solution
for
PFAS
removal,
addressing
critical
gaps
current
treatment
technologies.
Using
liquid
chromatography–tandem
mass
spectrometry
(LC-MS/MS),
the
nanocages─[oNC]8PF6,
[Co2+-oNC]8PF6,
[Co3+(N≡O)-oNC]8PF6─were
evaluated
their
ability
sorb
mixture
38
PFAS,
including
emerging
contaminants
like
GenX,
from
various
matrices
at
concentration
50
ng/mL.
The
achieved
exceptional
removal
efficiencies,
with
optimal
results
obtained
when
[oNC]8PF6
[Co2+-oNC]8PF6
were
combined
1:4
ratio.
created
synergistic
effect,
enabling
sorption
both
short-
long-chain
achieving
average
efficiencies
90%
Nanopure
groundwater,
80%
influent
sewage.
nanocage
consistently
outperformed
activated
carbon,
particularly
complex
such
sewage,
where
carbon
presented
lower
efficiency,
especially
perfluoroalkane
sulfonamido
substances.
reached
equilibrium
within
15
min
maintained
performance
across
multiple
methanolic
regeneration
cycles,
highlighting
operational
durability.
NMR
spectroscopy
computational
studies
revealed
that
occurs
via
hydrophobic
electrostatic
interactions,
well
partial
intercalation,
selectivity
molecules
bearing
sulfonate
sulfonamide
head
groups
chain
lengths
five
or
more.
Early
stage
eco-toxicological
assessments
confirmed
environmental
safety
these
nanocages,
showing
no
adverse
effects
below
0.005
μM.
By
combining
modular,
scalable
sustainable
material
synthesis,
this
sets
new
direction
developing
precise,
environmentally
responsible
solutions.
Physiologia,
Год журнала:
2024,
Номер
4(4), С. 517 - 567
Опубликована: Дек. 16, 2024
The
pervasive
presence
of
per-
and
polyfluoroalkyl
substances
(PFAS)
in
the
environment
their
persistent
nature
raise
significant
concerns
regarding
impact
on
human
health.
This
review
delves
into
obesogenic
potential
PFAS,
shedding
light
mechanisms
action,
epidemiological
correlations
with
obesity
metabolic
disorders,
challenges
faced
regulatory
frameworks.
characterized
by
carbon-fluorine
chains,
are
ubiquitous
various
consumer
products,
leading
to
widespread
exposure
through
ingestion
contaminated
food
water.
Emerging
evidence
suggests
that
PFAS
may
act
as
endocrine-disrupting
chemicals,
interfering
lipid
metabolism
hormone
functions
related
obesity.
We
examine
vitro,
vivo,
human,
silico
studies
explore
interaction
PPARs
other
molecular
targets,
influencing
adipogenesis
homeostasis.
Furthermore,
highlights
investigating
association
between
maternal
risk
offspring,
presenting
mixed
inconclusive
findings
underscore
complexity
effects
Presently,
there
major
studying
toxicity,
including
chemical
diversity
limitations
current
guidelines,
remediation,
detoxification.
emphasizes
need
for
a
multidisciplinary
approach,
combining
advanced
analytical
methods,
models,
comprehensive
studies,
unravel
inform
effective
public
health
strategies.
