Neuroscience Letters, Год журнала: 2023, Номер 817, С. 137532 - 137532
Опубликована: Окт. 20, 2023
Язык: Английский
Molecules, Год журнала: 2023, Номер 28(7), С. 3215 - 3215
Опубликована: Апрель 4, 2023
Infrared spectroscopy (wavelengths ranging from 750–25,000 nm) offers a rapid means of assessing the chemical composition wide range sample types, both for qualitative and quantitative analyses. Its use in food industry has increased significantly over past five decades it is now an accepted analytical technique routine analysis certain analytes. Furthermore, commonly used screening quality control purposes numerous settings, albeit not typically bioactive compounds. Using Scopus database, systematic search literature years between 2016 2020 identified 45 studies using near-infrared 17 mid-infrared quantification compounds products. The most common assessed were polyphenols, anthocyanins, carotenoids ascorbic acid. Numerous factors affect accuracy developed model, including analyte class concentration, matrix type, instrument geometry, wavelength selection spectral processing/pre-processing methods. Additionally, only few validated on independently sourced samples. Nevertheless, results demonstrate some promise infrared estimation matrices.
Язык: Английский
Процитировано
45
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(5), С. 2698 - 2698
Опубликована: Фев. 26, 2024
Oxidative stress (OS) and inflammation are two important well-studied pathological hallmarks of neurodegenerative diseases (NDDs). Due to elevated oxygen consumption, the high presence easily oxidizable polyunsaturated fatty acids weak antioxidant defenses, brain is particularly vulnerable oxidative injury. Uncertainty exists over whether these deficits contribute development NDDs or solely a consequence neuronal degeneration. Furthermore, linked, it known that OS can affect inflammatory response. In this review, we will overview last findings about pathways in principal NDDs. Moreover, focus more depth on amyotrophic lateral sclerosis (ALS) understand how anti-inflammatory antioxidants drugs have been used for treatment still incurable motor neuron (MN) disease. Finally, analyze past actual clinical trials future perspectives study mechanisms.
Язык: Английский
Процитировано
45
Acta Pharmaceutica Sinica B, Год журнала: 2024, Номер 15(1), С. 15 - 34
Опубликована: Окт. 16, 2024
Neuroprotection is a proactive approach to safeguarding the nervous system, including brain, spinal cord, and peripheral nerves, by preventing or limiting damage nerve cells other components. It primarily defends central system against injury from acute progressive neurodegenerative disorders. Oxidative stress, an imbalance between body's natural defense mechanisms generation of reactive oxygen species, crucial in developing neurological Due its high metabolic rate consumption, brain particularly vulnerable oxidative stress. Excessive ROS damages essential biomolecules, leading cellular malfunction neurodegeneration. Several disorders, Alzheimer's, Parkinson's, Amyotrophic lateral sclerosis, multiple ischemic stroke, are associated with Understanding impact stress these conditions for new treatment methods. Researchers exploring using antioxidants molecules mitigate aiming prevent slow down progression diseases. By understanding intricate interplay scientists hope pave way innovative therapeutic preventive approaches, ultimately improving individuals' living standards.
Язык: Английский
Процитировано
43
Cell Biochemistry and Biophysics, Год журнала: 2024, Номер 82(2), С. 457 - 477
Опубликована: Март 12, 2024
Язык: Английский
Процитировано
32
BioFactors, Год журнала: 2024, Номер 50(4), С. 693 - 708
Опубликована: Янв. 16, 2024
Abstract Alzheimer's disease (AD) constitutes a multifactorial neurodegenerative pathology characterized by cognitive deterioration, personality alterations, and behavioral shifts. The ongoing brain impairment process poses significant challenges for therapeutic interventions due to activating multiple neurotoxic pathways. Current pharmacological have shown limited efficacy are associated with side effects. Approaches focusing on the early interference pathways, before activation of broad processes, could be promising slow down symptomatic progression disease. Curcumin—an integral component traditional medicine in numerous cultures worldwide—has garnered interest as AD treatment. research indicates that curcumin may exhibit potential pathologies, attributed its potent anti‐inflammatory antioxidant properties. Additionally, derivatives demonstrated an ability modulate cellular pathways via epigenetic mechanisms. This article aims raise awareness neuroprotective properties curcuminoids provide benefits AD. paper provides comprehensive overview against signaling involved summarizes recent evidence biological efficiency curcumins vivo.
Язык: Английский
Процитировано
20
Molecular Brain, Год журнала: 2024, Номер 17(1)
Опубликована: Июль 17, 2024
Abstract Alzheimer’s disease (AD) is a degenerative neurological condition that gradually impairs cognitive abilities, disrupts memory retention, and impedes daily functioning by impacting the cells of brain. A key characteristic AD accumulation amyloid-beta (Aβ) plaques, which play pivotal roles in progression. These plaques initiate cascade events including neuroinflammation, synaptic dysfunction, tau pathology, oxidative stress, impaired protein clearance, mitochondrial disrupted calcium homeostasis. Aβ also closely associated with other hallmark features AD, underscoring its significance. generated through cleavage amyloid precursor (APP) plays dual role depending on processing pathway. The non-amyloidogenic pathway reduces production has neuroprotective anti-inflammatory effects, whereas amyloidogenic leads to peptides, Aβ40 Aβ42, contribute neurodegeneration toxic effects AD. Understanding multifaceted Aβ, particularly crucial for developing effective therapeutic strategies target metabolism, aggregation, clearance aim mitigating detrimental consequences disease. This review aims explore mechanisms functions under normal abnormal conditions, examining both beneficial effects.
Язык: Английский
Процитировано
18
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
5
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 141, С. 111919 - 111919
Опубликована: Июль 17, 2021
Herbal antioxidant like curcumin holds great potential to treat neurodegenerative disease Alzheimer's disease. However, its therapeutic potency is obstructed due rapid metabolism, poor solubility, GI susceptibility, enzymatic degradation and lower bioavailability. Thus, the present work aimed design optimize curcumin-loaded NLC (CNL) with higher drug entrapment, prolonged release better stability. CNL was prepared by modified melt emulsification method followed ultrasonication. The formulation optimized 3 factor level Box-Behnken using solid: liquid lipid, surfactant concentration ultrasonication time as independent variable while particle size, entrapment efficiency % dependant variable. suggested 3.092 solid:liquid 2.131% 4.757 min fit best get formulation. size of noted 124.37 ± 55.81 nm, which in acceptable range for brain delivery. SEM results also comply this (near 150 nm) demonstrated almost spherical uniform particles porous uneven surface structures. PDI, zeta potential, were observed 0.201 0.00, - 17.2 2.35 mV, 93.62 0.68% 92.73 0.06%, respectively. initial burst subsequent 48 h. Weibull kinetic equation 0.9958 R2, minimum AIC maximum MSC value found explain behavior. β exponent diffusional coefficient (n) indicated combined mechanism Fickian diffusion mechanism. Formulation stable at different storage condition.
Язык: Английский
Процитировано
96
Antioxidants, Год журнала: 2020, Номер 9(11), С. 1048 - 1048
Опубликована: Окт. 27, 2020
Plants are phytochemical hubs containing antioxidants, essential for normal plant functioning and adaptation to environmental cues delivering beneficial properties human health. Therefore, knowledge on the antioxidant potential of different species their nutraceutical pharmaceutical is utmost importance. Exploring this scientific research field provides fundamental clues (1) stress responses adaptive evolution harsh conditions (2) (new) natural antioxidants with a functional versatility prevent treat pathologies. These can be valorized via plant-derived foods products. Cuba contains an enormously rich biodiversity harboring great potential. Besides opening new avenues implementation sustainable agroecological practices in crop production, it will also contribute strategies preserve simultaneously improve nature management policies Cuba. This review overview protection health directed valorization these emphasizing need conservation.
Язык: Английский
Процитировано
90
Biomedicine & Pharmacotherapy, Год журнала: 2021, Номер 143, С. 112236 - 112236
Опубликована: Сен. 30, 2021
The increased oxidative stress in the acceleration of aging process and development neuronal disorder are common feature detected neurodegenerative illness, such as Alzheimer's disease, Parkinson's Amyotrophic lateral sclerosis. Searching for new treatment against these diseases, inclusion exogenous antioxidant agents has shown good results. Flavonoids polyphenols compounds present plants, fruits vegetables that exhibit potent biological properties, which related to their chemical structure confer an excellent radical scavenging ability. design metal-flavonoid complexes allows obtain with improved physicochemical generating important increase flavonoid properties. This evidence we motive propose properties metal flavonoids can play role potential novel therapeutic strategies. review presents structure-activity relationship on three series complexes: M-(quercetin), M-(morin), M-(rutin). In general, observed coordination sites, ion type used, molar ratio metal:flavonoid complexes, factors activity. On evidences is a potentially viable approach combating diseases.
Язык: Английский
Процитировано
87