Probiotics: health benefits, microencapsulation, and viability, combination with natural compounds, and applications in foods
Food Bioscience,
Год журнала:
2025,
Номер
unknown, С. 106253 - 106253
Опубликована: Фев. 1, 2025
Язык: Английский
Microbiome-based therapies for Parkinson’s disease
Frontiers in Nutrition,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 6, 2024
The
human
gut
microbiome
dysbiosis
plays
an
important
role
in
the
pathogenesis
of
Parkinson’s
disease
(PD).
bidirectional
relationship
between
enteric
nervous
system
(ENS)
and
central
(CNS)
under
mediation
gut-brain
axis
control
gastrointestinal
functioning.
This
review
article
discusses
key
mechanisms
by
which
modifications
composition
function
microbiota
(GM)
influence
PD
progression
motor
loss.
Increased
intestinal
permeability,
chronic
inflammation,
oxidative
stress,
α-synuclein
aggregation,
neurotransmitter
imbalances
are
some
factors
that
govern
pathology
progression.
bacterial
taxa
associated
with
development
discussed
emphasis
on
(ENS),
as
well
impact
bacteria
dopamine
production
levodopa
metabolism.
pathophysiology
course
several
inflammatory
markers,
including
TNF-α,
IL-1β,
IL-6.
Emerging
therapeutic
strategies
targeting
include
probiotics,
prebiotics,
synbiotics,
postbiotics,
fecal
transplantation
(FMT).
explored
how
dietary
changes
may
affect
ways
can
(PD),
a
focus
nutrition-based,
Mediterranean,
ketogenic
diets.
comprehensive
synthesizes
current
evidence
explores
its
potential
target.
Understanding
these
complex
interactions
assist
novel
diagnostic
tools
treatment
options
for
this
neurodegenerative
disorder.
Язык: Английский
Recent advances in therapeutic probiotics: insights from human trials
Clinical Microbiology Reviews,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
SUMMARY
Recent
advances
in
therapeutic
probiotics
have
shown
promising
results
across
various
health
conditions,
reflecting
a
growing
understanding
of
the
human
microbiome’s
role
and
disease.
However,
comprehensive
reviews
integrating
diverse
effects
subjects
been
limited.
By
analyzing
randomized
controlled
trials
(RCTs)
meta-analyses,
this
review
provides
overview
key
developments
probiotic
interventions
targeting
gut,
liver,
skin,
vaginal,
mental,
oral
health.
Emerging
evidence
supports
efficacy
specific
strains
combinations
treating
wide
range
disorders,
from
gastrointestinal
(GI)
liver
diseases
to
dermatological
bacterial
vaginosis,
mental
diseases.
We
discuss
expanding
microbiome-organ
connections
underlying
mechanisms
action.
While
many
clinical
demonstrate
significant
benefits,
we
acknowledge
areas
requiring
further
large-scale
studies
establish
definitive
optimal
treatment
protocols.
The
addresses
challenges
standardizing
research
methodologies
emphasizes
importance
considering
individual
variations
microbiome
composition
host
genetics.
Additionally,
explore
emerging
concepts
such
as
oral-gut-brain
axis
future
directions,
including
high-resolution
profiling,
host-microbe
interaction
studies,
organoid
models,
artificial
intelligence
applications
research.
Overall,
offers
update
on
current
state
multiple
domains
health,
providing
insights
into
directions
potential
for
revolutionize
preventive
medicine.
Язык: Английский
The role of the gut microbiome in Parkinson’s disease
Future Neurology,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 29, 2025
Язык: Английский
Randomized controlled trial evaluating synbiotic supplementation as an adjuvant therapy in the treatment of Parkinson’s disease
Inflammopharmacology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Язык: Английский
Dietary live microbe intake and its association with Parkinson’s disease in American adults: an NHANES analysis (1999–2018)
Frontiers in Nutrition,
Год журнала:
2025,
Номер
12
Опубликована: Май 29, 2025
Background
Diet
plays
a
crucial
role
in
sustaining
healthy
body,
and
microbes
have
attracted
significant
scholarly
interest
recent
years
as
an
essential
component
of
diet.
This
study
aims
to
explore
the
association
between
dietary
live
microbe
intake
incidence
Parkinson’s
Disease
(PD)
among
adults
over
40
old.
Methods
A
total
26,033
subjects
NHANES
1999–2018
were
included
this
study,
comprising
314
patients
with
PD,
which
divided
into
three
groups
based
on
their
foods
different
levels
microbial
content:
high,
medium,
low.
The
assessment
subjects’
was
conducted
through
self-reported
questionnaire.
Results
distribution
follows:
34.5%
had
low
intake,
45.4%
medium
20.1%
high
intake.
multivariable
logistic
regression
analysis
revealed
that
(OR
=
0.52,
95%
CI:
0.37–0.74)
0.73,
0.57–0.93)
exhibits
reduced
prevalence
PD
compared
those
Restricted
cubic
spline
(RCS)
indicated
linear
PD.
Furthermore,
stratified
analyses
demonstrate
research
variables
more
pronounced
without
obesity.
Conclusion
demonstrates
inverse
Язык: Английский
Trends and hotspots on the relationship between gut microbiota and Parkinson’s Disease: a bibliometric analysis
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 30, 2024
Parkinson’s
disease
(PD)
is
a
neurodegenerative
disorder
that
significantly
impacts
patients’
quality
of
life.
Recent
evidence
has
highlighted
complex
relationship
between
the
gut
microbiota
(GM)
and
PD.
Understanding
this
crucial
for
potentially
targeting
GM
in
PD
treatment
expanding
therapeutic
options.
This
study
aimed
to
comprehensively
analyze
global
landscape,
trends,
research
focus
on
using
bibliometric
analysis.
Utilizing
publications
from
Web
Science
Core
Collection
(WsSCC),
tools
such
as
R
package
‘Bibliometrix,’
VOS
viewer,
CiteSpace
software
were
employed
assess
parameters
like
yearly
publications,
countries/regions,
institutions,
authors.
Research
trends
hotspots
identified
through
keyword
The
results
revealed
1,161
articles
published
2013-2023,
with
China
leading
(n=352,
30.31%
total),
while
United
States
had
higher
influence
(H-index=58).
University
California
System
was
top
institution
terms
(n=35),
National
Natural
Foundation
funding
most
projects
(n=172).
Keshavarzian
A
Sampson
TR
authors
highest
publication
co-citation
counts,
respectively.
International
Journal
Molecular
Sciences
(n=48).
Keyword
analysis
parkinson’s
disease,
microbiota,
short-chain
fatty
acids,
inflammation,
probiotics
main
topics.
Biomarkers,
ketogenic
diet,
NF-κB
recent
(2021-2023).
current
conducts
an
objective
comprehensive
these
identifying
field
research.
findings
offer
valuable
insights
scholars
globally
in-vestigate
potential
strategies
Disease.
Язык: Английский
Role of selected nutritional factors in the prevention and treatment of Parkinson’s disease – a review
Aktualności Neurologiczne,
Год журнала:
2024,
Номер
24(2), С. 51 - 58
Опубликована: Авг. 28, 2024
Parkinson’s
disease
is
the
second
most
common
neurodegenerative
disorder,
characterised
by
progressive
death
of
dopaminergic
neurons
in
substantia
nigra.
The
prevalence
increasing
and
becoming
a
major
health
problem
nowadays
due
to
aging
society.
aim
this
study
was
conduct
comprehensive
review
literature
exploring
association
between
specific
dietary
components
such
as
vitamin
B12,
omega-3
fatty
acids,
D,
E,
probiotics.
A
search
performed
medical
database
PubMed.
Articles
English
were
retrieved.
impact
various
nutritional
ingredients
on
occurrence,
symptom
severity,
progression
examined.
An
additional
focus
underlying
mechanisms,
including
oxidative
stress
neuroinflammation,
through
which
may
exert
their
effects
development
disorder.
Evidence
suggests
that
early
supplementation
B12
might
mitigate
cognitive
dysfunction,
acids
reduce
progression,
probiotics
alleviate
motor
non-motor
symptoms,
particularly
constipation.
In
addition,
D
deficiency
patients
with
disease.
Furthermore,
researchers
have
reported
neuroprotective
E
animal
studies,
though
human
studies
are
inconclusive.
Current
research
provides
evidence
diet
influence
onset
course
approach
gives
new
possibilities
regarding
prevention
This
elucidates
interventions
be
considered
an
adjunctive
strategy
pharmacological
therapies.
However,
further
topic
necessary.
Язык: Английский