Memory-Enhancing and Anxiolytic Effects of the Rose of Jericho on Sleep Deprivation-Related Cognitive and Behavioral Changes
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Background:
Sleep
is
a
crucial
physiological
phenomenon
that
enables
the
body
to
engage
in
restoration
and
rejuvenation.
Remarkably,
even
limited
periods
of
sleep
deprivation
(SD)
can
adversely
affect
cognitive
functions
such
as
memory
retention,
emotional
regulation,
data
processing,
concentration.
The
Rose
Jericho
(RoJ)
has
been
considered
more
than
plant
demonstrated
potential
therapeutic
actions
childbirth,
respiratory
diseases,
gastrointestinal
disorders,
cancer.
effect
RoJ
on
memory,
cognition,
behavior
not
yet
well-studied.
Objectives:
present
study
aimed
investigate
possible
effects
behavior,
motor
coordination
rat
model
SD.
Materials
methods:
Thirty
male
Wistar
albino
rats
weighing
120-150
g
were
used
study.
acclimatized
trained
then
randomly
divided
into
three
groups:
control
(C),
sleep-deprived
(SD),
SD
treated
with
(SD+RoJ).
Spatial
learning
assessed
using
Morris
Water
Maze
(MWM)
test,
while
anxiety-related
behaviors
evaluated
through
Elevated
Plus
(EPM)
test.
rotarod
test
was
assess
coordination.
Results:
revealed
significant
behavioral
performance
improvements
SD+RoJ
group
across
all
tests.
In
MWM
exhibited
marked
increase
duration
(29.5
±
3.57
sec)
reduction
average
speed
(1.9
0.3
cm/s)
when
compared
C
(13.41
1.57
sec
5.9
0.34
cm/s,
respectively).
Interestingly,
significantly
reduced
(19.75
3.36
improved
rats'
(6.06
0.27
group.
EPM
spent
less
time
open
arms
(16.2
9.44
(59.8
3.29
sec).
(45.8
11.64
Moreover,
showed
notable
improvement
open-arm
entries
(7
2.39)
(1.6
0.81).
Rotarod
decline
latency
fall
(44.2
9.5
(228.67
35.44
longer
falling
(165
28.77
Conclusion:
Treatment
alleviated
SD-dependent
impairment,
anxiety,
Supplementation
may
offer
benefits,
including
boosting
improving
reducing
anxiety
depression,
enhancing
Язык: Английский
Efficacy and Tolerability of a Chemically Characterized Scutellaria lateriflora L. Extract-Based Food Supplement for Sleep Management: A Single-Center, Controlled, Randomized, Crossover, Double-Blind Clinical Trial
Nutrients,
Год журнала:
2025,
Номер
17(9), С. 1491 - 1491
Опубликована: Апрель 28, 2025
Background/Objectives:
Primary
insomnia
is
characterized
by
persistent
sleeplessness
that
not
caused
medical,
psychological,
or
environmental
factors.
It
defined
difficulty
initiating
maintaining
sleep
for
at
least
one
month,
leading
to
significant
distress
impairment
in
daily
functioning.
This
randomized,
crossover,
double-blind,
placebo-controlled
clinical
trial
aimed
assess
the
efficacy
and
tolerability
of
a
Scutellaria
lateriflora
L.
extract-based
food
supplement
subjects
with
mild
moderate
primary
insomnia.
Methods:
A
total
66
participants,
aged
18–70
years,
were
randomly
allocated
into
two
groups
(1:1
allocation
ratio)
received
either
(400
mg/day)
placebo
56
days,
separated
28-day
washout
period.
The
effectiveness
was
assessed
using
Pittsburgh
Sleep
Quality
Index
(PSQI)
as
outcome
measure.
Secondary
outcomes
included
sleep-wake
cycle
parameters
(sleep
onset
latency,
efficiency,
time)
Visual
Analog
Scale
(VAS).
Results:
improvement
balance
following
supplementation
S.
lateriflora,
reflected
enhanced
scores
both
secondary
outcomes,
observed.
Furthermore,
none
participants
reported
adverse
effects
from
supplement.
Conclusions:
Overall,
these
findings
suggest
safe
effective
strategy
restoring
improving
quality
life
individuals
Язык: Английский