Evaluation of the Potency of Repurposed Antiretrovirals in HBV Therapy: A Narrative Investigation of the Traditional Medicine Alternatives
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1523 - 1523
Опубликована: Фев. 11, 2025
Hepatitis
B
is
one
of
the
killer
communicable
diseases,
with
a
global
estimation
1.1
million
deaths
resulting
from
liver
diseases
annually.
The
search
for
HBV
therapeutics
has
resulted
in
repurposing
existing
antiretrovirals
(ARVs)
treatment,
considering
their
shared
common
replication
mechanisms.
This
review
aimed
at
evaluating
potencies
some
repurposed
ARVs
used
analyzing
mechanisms
viral
replications
and
HIV,
investigating
potentials
traditional
medicines
as
an
alternative
treatment
patients.
topical
keywords
drug
repurposing,
repositioning,
antiretrovirals,
hepatitis
HBV,
natural
products,
medicines,
title,
abstract
were
searched
PubMed,
Web
Science,
Google
Scholar.
advanced
included
five
years,
2019-2024.
result
was
filtered
377
to
110
relevant
articles.
evaluation
reveals
that
CD4+
T
cells
are
targeted
by
while
targets
its
associated
(cirrhosis
hepatocellular
carcinoma
(HCC)).
Furthermore,
treatments
available
only
prevent
or
slow
down
progression
cirrhosis,
reduce
HCC
incidence,
can
improve
quality
life
increase
expectancy;
however,
they
not
curative
HBV.
Traditional
medicines/natural
product
extracts
phytochemicals
exert
anti-HBV
effects
through
different
improved
therapeutic
when
combined
properly.
investigation
further
consideration
silico
approach
might
streamline
development
but
also
contribute
deeper
understanding
pathogenesis.
Therefore,
we
recommend
integration
computational
design
methods
medicine
screening
discovering
new
bioactive
candidates.
Язык: Английский
Potential Benefits of In Silico Methods: A Promising Alternative in Natural Compound’s Drug Discovery and Repurposing for HBV Therapy
Pharmaceuticals,
Год журнала:
2025,
Номер
18(3), С. 419 - 419
Опубликована: Март 16, 2025
Hepatitis
B
virus
(HBV)
is
an
important
global
public
health
issue.
The
World
Health
Organization
(WHO)
2024
Global
Report
estimated
that
the
prevalence
of
people
living
with
HBV
infection
254
million,
incidence
1.2
million
new
infections
yearly.
Previous
studies
have
shown
natural
compounds
antiviral
inhibition
potentials.
In
silico
methods
such
as
molecular
docking,
virtual
screening,
pharmacophore
modeling,
quantitative
structure–activity
relationship
(QSAR),
and
dynamic
simulations
been
successfully
applied
in
identifying
bioactive
strong
binding
energies
treatment
targets.
COVID-19
pandemic
necessitated
importance
repurposing
already
approved
drugs
using
methods.
This
study
aimed
at
unveiling
benefits
techniques
a
potential
alternative
compounds’
drug
discovery
for
therapy.
Relevant
articles
from
PubMed,
Google
Scholar,
Web
Science
were
retrieved
analyzed.
Furthermore,
this
comprehensively
reviewed
literature
containing
identified
essential
proteins.
Notably,
hesperidin,
quercetin,
kaempferol,
myricetin,
flavonoids
hepatitis
surface
antigen
(HBsAg).
investigation
reveals
offer
understanding
mechanisms
action,
reveal
previously
overlooked
viral
targets
(including
PreS1
Domain
HBsAg
cccDNA
(Covalently
Closed
Circular
DNA)
regulators,
facilitate
creation
specific
inhibitors.
integration
silico,
vitro,
vivo
insights
further
highlight
Moreover,
combination
compounds,
approach,
improves
chances
personalized
precision
medicine
treatment.
Therefore,
we
recommend
strategies
combine
vivo,
approaches
to
effective
drugs.
Язык: Английский