Cells,
Год журнала:
2024,
Номер
13(11), С. 948 - 948
Опубликована: Май 30, 2024
With
the
lack
of
specific
signs
and
symptoms,
pancreatic
ductal
adenocarcinoma
(PDAC)
is
often
diagnosed
at
late
metastatic
stages,
resulting
in
poor
survival
outcomes.
Among
various
biomarkers,
microRNA-21
(miR-21),
a
small
non-coding
RNA,
highly
expressed
PDAC.
By
inhibiting
regulatory
proteins
3′
untranslated
regions
(UTR),
miR-21
holds
significant
roles
PDAC
cell
proliferation,
epithelial–mesenchymal
transition,
angiogenesis,
as
well
cancer
invasion,
metastasis,
resistance
therapy.
We
conducted
systematic
search
across
major
databases
for
articles
on
mainly
published
within
last
decade,
focusing
their
diagnostic,
prognostic,
therapeutic,
biological
roles.
This
rigorous
approach
ensured
comprehensive
review
miR-21’s
multifaceted
role
cancers.
In
this
review,
we
explore
current
understandings
future
directions
regarding
regulation,
therapeutic
potential
targeting
exhaustive
discusses
involvement
transition
(EMT),
apoptosis
modulation,
its
therapy
resistance.
Also
discussed
interplay
between
molecular
pathways
that
contribute
to
tumor
progression,
with
reference
adenocarcinoma.
Journal of Experimental & Clinical Cancer Research,
Год журнала:
2022,
Номер
41(1)
Опубликована: Апрель 23, 2022
Abstract
Background
Chemoresistance
of
pancreatic
cancer
is
the
main
reason
for
poor
treatment
effect
patients.
Exploring
chemotherapy
resistance-related
genes
has
been
a
difficult
and
hot
topic
oncology.
Numerous
studies
implicate
key
roles
circular
RNAs
(circRNAs)
in
development
cancer.
However,
regulation
circRNAs
process
ductal
adenocarcinoma
(PDAC)
resistance
not
yet
fully
clear.
Methods
Based
on
cross-analysis
Gene
Expression
Omnibus
(GEO)
database
data
our
center,
we
explored
new
molecule,
hsa_circ_0078297
(circ-MTHFD1L),
related
to
resistance.
QRT-PCR
was
used
detect
expression
circRNAs,
miRNAs,
mRNAs
human
PDAC
tissues
their
matched
normal
tissues.
The
interaction
between
circ-MTHFD1L
miR-615-3p/RPN6
signal
axis
confirmed
by
series
experiments
such
as
Dual-luciferase
reporter
assay,
fluorescence
situ
hybridization
(FISH)
RNA
immunoprecipitation
(RIP)
assays.
Results
Circ-MTHFD1L
significantly
increased
cells.
And
patients,
higher
level
circ-MTHFD1L,
worse
prognosis.
Mechanism
analysis
showed
that
an
endogenous
miR-615-3p
sponge,
upregulates
RPN6,
thereby
promoting
DNA
damage
repair
exerting
its
enhancing
gemcitabine
More
importantly,
also
found
Silencing
combined
with
olaparib
can
increase
sensitivity
gemcitabine.
Conclusion
maintains
through
axis.
may
be
molecular
marker
effective
PDAC.
Cell Reports,
Год журнала:
2023,
Номер
42(6), С. 112581 - 112581
Опубликована: Июнь 1, 2023
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
a
devastating
disease
with
limited
set
of
known
driver
mutations
but
considerable
cancer
cell
heterogeneity.
Phosphoproteomics
provides
readout
aberrant
signaling
and
has
the
potential
to
identify
new
targets
guide
treatment
decisions.
Using
two-step
sequential
phosphopeptide
enrichment,
we
generate
comprehensive
phosphoproteome
proteome
nine
PDAC
lines,
encompassing
more
than
20,000
phosphosites
on
5,763
phospho-proteins,
including
316
protein
kinases.
By
using
integrative
inferred
kinase
activity
(INKA)
scoring,
multiple
(parallel)
activated
kinases
that
are
subsequently
matched
inhibitors.
Compared
high-dose
single-drug
treatments,
INKA-tailored
low-dose
3-drug
combinations
against
demonstrate
superior
efficacy
organoid
cultures,
patient-derived
xenografts.
Overall,
this
approach
particularly
effective
aggressive
mesenchymal
model
compared
epithelial
in
both
preclinical
settings
may
contribute
improved
outcomes
patients.
Pancreatic
cancer
is
one
of
the
most
lethal
neoplasms
worldwide;
it
aggressive
in
nature
and
has
a
poor
prognosis.
The
overall
survival
rate
for
pancreatic
low.
Most
patients
present
non-specific
symptoms
advanced
stages,
which
generally
leads
to
late
diagnosis,
at
point
there
no
option
curative
surgery.
treatment
metastatic
includes
systemic
therapy,
some
cases
radiotherapy,
more
recently,
molecular
targeted
therapies,
can
positively
impact
control
improve
quality
life.
This
review
provides
an
overview
landscape
based
on
recent
literature,
as
well
current
options
with
cancer.
Cancer Letters,
Год журнала:
2024,
Номер
585, С. 216640 - 216640
Опубликована: Янв. 28, 2024
Gemcitabine,
a
pivotal
chemotherapeutic
agent
for
pancreatic
ductal
adenocarcinoma
(PDAC),
frequently
encounters
drug
resistance,
posing
significant
clinical
challenge
with
implications
PDAC
patient
prognosis.
In
this
study,
employing
an
integrated
approach
involving
bioinformatic
analyses
from
multiple
databases,
we
unveil
CSNK2A1
as
key
regulatory
factor.
The
patient-derived
xenograft
(PDX)
model
further
substantiates
the
critical
role
of
in
gemcitabine
resistance
within
context
PDAC.
Additionally,
targeted
silencing
expression
significantly
enhances
sensitivity
cells
to
treatment.
Mechanistically,
CSNK2A1's
transcriptional
regulation
is
mediated
by
H3K27
acetylation
Moreover,
identify
activator
autophagy,
and
enhanced
autophagy
drives
resistance.
Silmitasertib,
established
inhibitor,
can
effectively
inhibit
autophagy.
Notably,
combinatorial
treatment
Silmitasertib
demonstrates
remarkable
efficacy
treating
summary,
our
study
reveals
potent
predictive
factor
inhibition
represents
promising
therapeutic
strategy
restore
PDAC,
offering
hope
improved
outcomes.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 2507 - 2528
Опубликована: Март 1, 2024
Background:
Cancer
continues
to
be
a
prominent
issue
in
the
field
of
medicine,
as
demonstrated
by
recent
studies
emphasizing
significant
role
autophagy
development
cancer.
Traditional
Chinese
Medicine
(TCM)
provides
variety
anti-tumor
agents
capable
regulating
autophagy.
However,
clinical
application
autophagy-modulating
compounds
derived
from
TCM
is
impeded
their
restricted
water
solubility
and
bioavailability.
To
overcome
this
challenge,
utilization
nanotechnology
has
been
suggested
potential
solution.
Nonetheless,
current
body
literature
on
nanoparticles
delivering
TCM-derived
for
cancer
treatment
limited,
lacking
comprehensive
summaries
detailed
descriptions.
Methods:
Up
November
2023,
research
study
was
conducted
gather
relevant
data
using
databases,
including
PubMed,
ScienceDirect,
Springer
Link,
Web
Science,
CNKI.
The
keywords
utilized
investigation
included
"autophagy",
"nanoparticles",
"traditional
medicine"
"anticancer".
Results:
This
review
analysis
overcoming
delivery
challenges
enhancing
anti-cancer
properties
TCM.
evaluation
based
synthesis
different
classes
TCM,
mechanisms
action
treatment,
benefits
reported
various
scholarly
sources.
findings
indicate
that
shows
availability
thereby
opening
up
plethora
therapeutic
avenues.
Conclusion:
Nanotechnology
enhance
efficacy
traditional
through
regulation
Keywords:
autophagy,
nano-delivery,
anti-cancer,
medicine
