From Short- to Long-Term Effects of C-Section Delivery on Microbiome Establishment and Host Health DOI Creative Commons
David Ríos-Covián, Philippe Langella, Rebeca Martín

и другие.

Microorganisms, Год журнала: 2021, Номер 9(10), С. 2122 - 2122

Опубликована: Окт. 9, 2021

The establishment of gut microbiota has been proven to be impacted by several factors during pregnancy, delivery, and neonate periods. body evidence describing C-section delivery (CSD) as one the most disruptive events early life expanded in recent years, concluding that CSD results a drastic change patterns. When comparing composition babies with vaginally delivered (VD) babies, former show microbiome closely resembles found environment mother’s skin, while VD more similar vaginal microbiome. Although these alterations normal tend disappear first months life, they still affect host health mid–long term since correlated higher risk infections non-transmissible diseases, such inflammatory allergies, metabolic diseases. In this phenomenon also studied other mammals, shedding light on mechanisms involved effects health. addition, strategies revert disruptions microbiomes caused are currently process development evaluation. review, we discuss advances research, from alteration possible development.

Язык: Английский

Tryptophan-rich diet ameliorates chronic unpredictable mild stress induced depression- and anxiety-like behavior in mice: The potential involvement of gut-brain axis DOI
Danna Wang, Jianbin Wu,

Peilin Zhu

и другие.

Food Research International, Год журнала: 2022, Номер 157, С. 111289 - 111289

Опубликована: Апрель 25, 2022

Язык: Английский

Процитировано

62
Why Are Bifidobacteria Important for Infants? DOI Creative Commons
Gerrit A. Stuivenberg, Jeremy P. Burton, Peter A. Bron

и другие.

Microorganisms, Год журнала: 2022, Номер 10(2), С. 278 - 278

Опубликована: Янв. 25, 2022

The presence of

Язык: Английский

Процитировано

60
Microbiota-immune-brain interactions: A lifespan perspective DOI Creative Commons
Anna Ratsika,

Joana S. Cruz Pereira,

Caoimhe M.K. Lynch

и другие.

Current Opinion in Neurobiology, Год журнала: 2022, Номер 78, С. 102652 - 102652

Опубликована: Дек. 1, 2022

There is growing appreciation of key roles the gut microbiota in maintaining homeostasis and influencing brain behaviour at critical windows across lifespan. Mounting evidence suggests that communication between could be to understanding multiple neuropsychiatric disorders, with immune system coming forefront as an important mechanistic mediator. Throughout lifespan, exchanges continuous reciprocal signals central nervous system. Intestinal microbial cues alter mediators consequences for host neurophysiology behaviour. Several factors challenge composition, which response release molecules neuro- immuno-active potential are crucial adequate neuro-immune interactions. In this review, contributing upkeep fine balance health disease these systems discussed, we elucidate implications inputs on

Язык: Английский

Процитировано

56
Microbiota-Gut-Brain Axis Regulation of Adult Hippocampal Neurogenesis DOI Open Access
Katherine E. Guzzetta, John F. Cryan, Olivia F. O’Leary

и другие.

Brain Plasticity, Год журнала: 2022, Номер 8(1), С. 97 - 119

Опубликована: Сен. 30, 2022

The birth, maturation, and integration of new neurons in the adult hippocampus regulates specific learning memory processes, responses to stress, antidepressant treatment efficacy. This process hippocampal neurogenesis is sensitive environmental stimuli, including peripheral signals from certain cytokines, hormones, metabolites, which can promote or hinder production survival neurons. trillions microorganisms resident gastrointestinal tract, collectively known as gut microbiota, also demonstrate ability modulate neurogenesis. In doing so, microbiota-gut-brain axis influence brain functions regulated by Unlike hippocampus, microbiota highly accessible direct interventions, such prebiotics, probiotics, antibiotics, be manipulated lifestyle choices diet. Therefore, understanding pathways shapes may reveal novel targets for non-invasive therapeutics treat disorders alterations have been implicated. review first outlines factors both microbiome neurogenesis, with cognizance that these effects might happen either independently due microbiota-driven mechanisms. We then highlight approaches investigating regulation axis. Finally, we summarize current evidence demonstrating microbiota's mechanisms driven through immune pathways, microbial endocrine signalling, nervous system, postulate implications disease onset treatment.

Язык: Английский

Процитировано

50
Decoding the neurocircuitry of gut feelings: Region-specific microbiome-mediated brain alterations DOI Creative Commons

B. Sharvin,

María R. Aburto, John F. Cryan

и другие.

Neurobiology of Disease, Год журнала: 2023, Номер 179, С. 106033 - 106033

Опубликована: Фев. 8, 2023

Research in the last decade has unveiled a crucial role for trillions of microorganisms that reside gut influencing host neurodevelopment across lifespan via microbiota-gut-brain axis. Studies have linked alterations composition, complexity, and diversity microbiota to changes behaviour including abnormal social interactions, cognitive deficits, anxiety- depressive-like phenotypes. Moreover, been with neurodevelopmental, neuropsychiatric, neurodegenerative disorders. Interestingly, there appears be specific brain regions governing neurocircuitry driving higher function are susceptible influence from manipulations microbiome. This review will aim elucidate region-specific effects mediated by microbiota, focus on translational animal models some existing human neuroimaging data. Compelling preclinical evidence suggests disruption normal signalling can detrimental prefrontal cortex, amygdala, hippocampus, hypothalamus, striatum. Furthermore, studies mediating functional connectivity structure traced back neurocognition behavioural output. Understanding these microbiota-mediated aid identifying unique therapeutic targets treating neurological disorders associated regions.

Язык: Английский

Процитировано

36
Biomimetic Nanostructural Materials Based on Placental Amniotic Membrane-derived Nanofibers for Self-healing and Anti-adhesion during Cesarean Section DOI Creative Commons

Honglei Zhu,

Fenghua Liu,

Yuru Liao

и другие.

Biomaterials, Год журнала: 2025, Номер 317, С. 123081 - 123081

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

2
Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols DOI Creative Commons
Kate R. Secombe, Ghanyah Al-Qadami, Courtney B. Subramaniam

и другие.

Gut Microbes, Год журнала: 2021, Номер 13(1)

Опубликована: Янв. 1, 2021

Fecal microbiota transplant (FMT) is a powerful tool used to connect changes in gut microbial composition with variety of disease states and pathologies. While FMT enables potential causal relationships be identified, the experimental details reported preclinical protocols are highly inconsistent and/or incomplete. This limitation reflects current lack authoritative guidance on reporting standards that would facilitate replication efforts ultimately reproducible science. We therefore systematically reviewed all mouse models goal formulating recommendations protocols. Search strategies were applied across three databases (PubMed, EMBASE, Ovid Medline) until June 30, 2020. Data related donor attributes, stool collection, processing/storage, recipient preparation, administration, quality control extracted. A total 1753 papers 241 identified for data extraction analysis. Of included, 92.5% positive outcome intervention. However, vast majority studies failed address core methodological aspects including use anaerobic conditions (91.7% lacked information), storage (49.4%), homogenization (33.6%), concentration (31.5%), volume (19.9%) administration route (5.3%). To these limitations, we developed theGuidelines Reporting Animal Transplant (GRAFT) guide FMT. The GRAFT will enable robust design, high-quality peer review, improving rigor translation knowledge gained through studies.

Язык: Английский

Процитировано

56
Microbiota and body weight control: Weight watchers within? DOI Creative Commons
Serena Boscaini, Sarah‐Jane Leigh, Aonghus Lavelle

и другие.

Molecular Metabolism, Год журнала: 2021, Номер 57, С. 101427 - 101427

Опубликована: Дек. 29, 2021

Despite several decades of research, managing body weight remains an unsolved clinical problem. Health problems associated with dysregulated weight, such as obesity and cachexia, exhibit gut microbiota alterations. There is increased interest in utilising the for control, it responds to intervention plays important role energy extraction from food, well biotransformation nutrients.

Язык: Английский

Процитировано

46
Sesamol ameliorates dextran sulfate sodium-induced depression-like and anxiety-like behaviors in colitis mice: the potential involvement of the gut–brain axis DOI
Bing Xia, Xiaoning Liu, Xiaohan Li

и другие.

Food & Function, Год журнала: 2022, Номер 13(5), С. 2865 - 2883

Опубликована: Янв. 1, 2022

Inflammatory bowel disease (IBD) is accompanied by some psychiatric disorders, including anxiety and depression. Sesamol has been reported to alleviate colitis symptoms depression-like behaviors caused chronic unpredictable mild stress, but its protective effect underlying neurobiological mechanism on IBD induced dextran sulfate sodium (DSS) accompanying anxiety-like remains still unclear. Here, we found that a six-week sesamol treatment (100 mg per kg bodyweight day) for DSS-induced mice predominantly prevented inflammatory response, epithelial barrier dysfunction via the gut-brain axis. alleviated neuroinflammatory responses suppressing TLR-4/NF-κB pathway, protected against oxidative stress upregulated Nrf2 antioxidant signaling pathway. Moreover, improved brain-derived neurotrophic factor (BDNF) upregulating BDNF/TrkB/CREB restored synaptic impairments enhanced norepinephrine (NE) serotonin (5-HT) levels. Importantly, correlation analysis showed gut lipopolysaccharide (LPS) content in serum were highly associated with behavioral performance biochemical indexes of brain. In summary, present study indicates novel nutritional intervention strategy preventing

Язык: Английский

Процитировано

32
Development of the gut microbiota in healthy children in the first ten years of life: associations with internalizing and externalizing behavior DOI Creative Commons
Yangwenshan Ou, Clara Belzer, Hauke Smidt

и другие.

Gut Microbes, Год журнала: 2022, Номер 14(1)

Опубликована: Фев. 19, 2022

Increasing evidence indicates that psychopathological disorders are associated with the gut microbiota. However, data largely lacking from long-term longitudinal birth cohorts, especially those comprising low-risk healthy individuals. Therefore, this study aims to describe microbiota development in children till age 10 years, as well investigate potential associations internalizing and externalizing behavior.

Язык: Английский

Процитировано

32