VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals DOI Creative Commons
Deepa L. Ramamurthy, A. Chen, Jiayu Zhou

и другие.

Current Biology, Год журнала: 2023, Номер 33(16), С. 3398 - 3408.e7

Опубликована: Июль 26, 2023

Vasoactive intestinal peptide (VIP) interneurons in sensory cortex modulate responses based on global exploratory behavior and arousal state, but their function during non-exploratory, goal-directed is not well understood. In particular, whether VIP cells are activated by cues, reward-seeking actions, or directly reinforcement unclear. We trained mice a Go/NoGo whisker touch detection task that included delay period other features designed to separate sensory-evoked, action-related, reward-related neural activity. Mice had lick response stimulus receive variable-sized reward. Using two-photon calcium imaging, we measured ΔF/F of L2/3 neurons somatosensory (S1) behavior. both expert novice mice, were strongly stimuli actions (licking), reinforcement. showed somatotopic tuning was spatially organized relative anatomical columns S1, unlike lick-related signals which widespread. suppressed, enhanced, when reward delivered, the amount suppression increased with size. This seen where delivery yoked licking. These results indicate besides state variables, local Instead, our consistent role for encoding expectation associated motor actions.

Язык: Английский

Locus Coeruleus Norepinephrine in Learned Behavior: Anatomical Modularity and Spatiotemporal Integration in Targets DOI Creative Commons
Vincent Breton‐Provencher, Gabrielle T. Drummond, Mriganka Sur

и другие.

Frontiers in Neural Circuits, Год журнала: 2021, Номер 15

Опубликована: Июнь 7, 2021

The locus coeruleus (LC), a small brainstem nucleus, is the primary source of neuromodulator norepinephrine (NE) in brain. LC receives input from widespread brain regions, and projects throughout forebrain, brainstem, cerebellum, spinal cord. neurons release NE to control arousal, but also context variety sensory-motor behavioral functions. Despite its brain-wide effects, much about role LC-NE behavior circuits controlling activity unknown. New evidence suggests that modular input-output organization could enable transient, task-specific modulation distinct regions. Future work must further assess whether this spatial modularity coincides with functional differences subpopulations acting at specific times, how such spatiotemporal specificity might influence learned behaviors. Here, we summarize state field present new ideas on

Язык: Английский

Процитировано

120
Noradrenergic modulation of rhythmic neural activity shapes selective attention DOI
Martin J. Dahl, Mara Mather, Markus Werkle‐Bergner

и другие.

Trends in Cognitive Sciences, Год журнала: 2021, Номер 26(1), С. 38 - 52

Опубликована: Ноя. 16, 2021

Язык: Английский

Процитировано

107
Pupil diameter is not an accurate real-time readout of locus coeruleus activity DOI Creative Commons
Marine Megemont, Jim McBurney-Lin, Hongdian Yang

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Фев. 2, 2022

Pupil diameter is often treated as a noninvasive readout of activity in the locus coeruleus (LC). However, how accurately it can be used to index LC not known. To address this question, we established graded relationship between pupil size changes and spiking mice, where dilation increased monotonically with number spikes. exists substantial variability such that only predict small fraction on moment-by-moment basis. In addition, exhibited large session-to-session fluctuations response identical optical stimulation LC. The variations pupil-LC were strongly correlated decision bias-related behavioral variables. Together, our data show an overall activity, further suggest dynamically modulated by brain states, supporting extending previous findings (Yang et al., 2021).

Язык: Английский

Процитировано

96
Coupling of pupil- and neuronal population dynamics reveals diverse influences of arousal on cortical processing DOI Creative Commons
Thomas Pfeffer, Christian Keitel, Daniel S. Kluger

и другие.

eLife, Год журнала: 2022, Номер 11

Опубликована: Фев. 8, 2022

Fluctuations in arousal, controlled by subcortical neuromodulatory systems, continuously shape cortical state, with profound consequences for information processing. Yet, how arousal signals influence population activity detail has so far only been characterized a few selected brain regions. Traditional accounts conceptualize as homogeneous modulator of neural across the cerebral cortex. Recent insights, however, point to higher specificity effects on different components and Here, we provide comprehensive account relationships between fluctuations neuronal human brain. Exploiting established link pupil size central performed concurrent magnetoencephalographic (MEG) pupillographic recordings large number participants, pooled three laboratories. We found cascade relative peak timing spontaneous dilations: Decreases low-frequency (2–8 Hz) temporal lateral frontal cortex, followed increased high-frequency (>64 mid-frontal regions, monotonic inverted U intermediate frequency-range (8–32 occipito-parietal Pupil-linked also coincided widespread changes structure aperiodic component activity, indicative excitation-inhibition balance underlying microcircuits. Our results novel basis studying modulation cognitive computations circuits.

Язык: Английский

Процитировано

72
Tonic and phasic transcutaneous auricular vagus nerve stimulation (taVNS) both evoke rapid and transient pupil dilation DOI Creative Commons
Lina Skora, Anna Marzecová, Gerhard Jocham

и другие.

Brain stimulation, Год журнала: 2024, Номер 17(2), С. 233 - 244

Опубликована: Фев. 28, 2024

BackgroundTranscutaneous auricular vagus nerve stimulation (tVNS or taVNS) is a non-invasive method of electrical the afferent pathway nerve, suggested to drive changes in putative physiological markers noradrenergic activity, including pupil dilation.ObjectiveHowever, it unknown whether different taVNS modes can map onto phasic and tonic activity. The effects on dilation humans are inconsistent, largely due differences protocols. Here, we attempted address these issues.MethodsWe investigated under (1 s) (30 taVNS, pre-registered, single-blind, sham-controlled, within-subject cross-over design, absence behavioural task.ResultsPhasic induced rapid increase size over baseline, significantly greater than sham stimulation, which rapidly declined after offset. Tonic similarly (and larger sham) returning baseline within 5 s, despite ongoing stimulation. Thus, both active closely resembled effect. There were no size, sustained size.ConclusionsThese results suggest that phasic- tonic-like standard parameters may modulate primarily mode as indexed by evoked dilation, above somatosensory effects. This result sheds light temporal profile with implications for their applicability further research.

Язык: Английский

Процитировано

20
Neurobehavioral meaning of pupil size DOI Creative Commons
Nikola Grujic, Rafael Polanìa, Denis Burdakov

и другие.

Neuron, Год журнала: 2024, Номер 112(20), С. 3381 - 3395

Опубликована: Июнь 25, 2024

Pupil size is a widely used metric of brain state. It one the few signals originating from that can be readily monitored with low-cost devices in basic science, clinical, and home settings. is, therefore, important to investigate generate well-defined theories related specific interpretations this metric. What exactly does it tell us about brain? Pupils constrict response light dilate during darkness, but also controls pupil irrespective luminosity. fluctuations resulting ongoing "brain states" are as arousal, what pupil-linked arousal how should interpreted neural, cognitive, computational terms? Here, we discuss some recent findings these issues. We identify open questions propose answer them through combination tasks, neurocomputational models, neurophysiological probing interconnected loops causes consequences size.

Язык: Английский

Процитировано

20
Pupil size reveals arousal level fluctuations in human sleep DOI Creative Commons
Manuel Carro‐Domínguez, Stephanie Huwiler,

Stella Oberlin

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 28, 2025

Abstract Recent animal research has revealed the intricate dynamics of arousal levels that are important for maintaining proper sleep resilience and memory consolidation. In humans, changes in level believed to be a determining characteristic healthy pathological but tracking fluctuations been methodologically challenging. Here we measured pupil size, an established indicator levels, by safely taping right eye open during overnight tested whether size affects cortical response auditory stimulation. We show change as function events across different temporal scales. particular, our results inversely related occurrence spindle clusters, marker resilience. Additionally, found prior stimulation influence evoked response, most notably delta power, several restorative regenerative functions sleep. Recording provides insights into interplay between oscillations.

Язык: Английский

Процитировано

3
Periaqueductal gray/dorsal raphe dopamine neurons contribute to sex differences in pain-related behaviors DOI Creative Commons
Waylin Yu, Dipanwita Pati, Melanie M. Pina

и другие.

Neuron, Год журнала: 2021, Номер 109(8), С. 1365 - 1380.e5

Опубликована: Март 19, 2021

Язык: Английский

Процитировано

99
A unified model of the task-evoked pupil response DOI Creative Commons
Charlie S. Burlingham, Saghar Mirbagheri, David J. Heeger

и другие.

Science Advances, Год журнала: 2022, Номер 8(16)

Опубликована: Апрель 20, 2022

The pupil dilates and reconstricts following task events. It is popular to model this task-evoked response as a linear transformation of event-locked impulses, whose amplitudes are used estimates arousal. We show that incorrect propose an alternative based on the physiological finding common neural input drives saccades size. arousal from our agreed with key predictions: Arousal scaled difficulty behavioral performance but was invariant small differences in trial duration. Moreover, offers unified explanation for wide range phenomena: entrainment size timing, modulation amplitude noise difficulty, reaction time-dependent timing amplitude, constrictory time-locked saccades, task-dependent distortion saccade-locked response.

Язык: Английский

Процитировано

47
Dissecting the functional organization of the C. elegans serotonergic system at whole-brain scale DOI Creative Commons
Ugur Dag, Ijeoma Nwabudike,

Di Kang

и другие.

Cell, Год журнала: 2023, Номер 186(12), С. 2574 - 2592.e20

Опубликована: Май 15, 2023

Serotonin influences many aspects of animal behavior. But how serotonin acts on its diverse receptors across the brain to modulate global activity and behavior is unknown. Here, we examine release in C. elegans alters brain-wide induce foraging behaviors, like slow locomotion increased feeding. Comprehensive genetic analyses identify three core (MOD-1, SER-4, LGC-50) that upon others (SER-1, SER-5, SER-7) interact with them this SER-4 induces behavioral responses sudden increases release, whereas MOD-1 persistent release. Whole-brain imaging reveals widespread serotonin-associated dynamics, spanning networks. We map all sites receptor expression connectome, which, together synaptic connectivity, helps predict which neurons show activity. These results reveal at defined a connectome

Язык: Английский

Процитировано

40