Developmental Cognitive Neuroscience, Год журнала: 2024, Номер 71, С. 101487 - 101487
Опубликована: Дек. 12, 2024
Язык: Английский
Pediatric Research, Год журнала: 2024, Номер unknown
Опубликована: Июль 3, 2024
Abstract In 1966, Howard Roffwarg proposed the ontogenic sleep hypothesis, relating neural plasticity and development to rapid eye movement (REM) sleep, a hypothesis that current fetal neonatal research is still exploring. Recently, technological advances have enabled researchers automatically quantify architecture, which has caused resurgence of in this field as attempts are made further elucidate important role pre- postnatal brain development. This article will review our understanding driver identify possible areas for future research. Impact The evidence date suggests Roffwarg’s ontogenesis correct. A better relationship between functional connectivity needed. Reliable, non-invasive tools assess NICU at home need be tested real-world environment best way promote healthy needs understood before clinical trials promoting optimizing quality neonates could undertaken.
Язык: Английский
Процитировано
4
IEEE Access, Год журнала: 2024, Номер 12, С. 39186 - 39203
Опубликована: Янв. 1, 2024
The rapidly evolving landscape of artificial intelligence (AI) and machine learning has placed data at the forefront healthcare innovation. Electroencephalography (EEG) gained significant attention for its potential to revolutionize applications. However, effective utilization EEG in advancing medical diagnoses treatment hinges on availability quality relevant datasets. In this context, we conducted a scoping review explore wealth datasets designed This serves as critical exploration current landscape, aiming identify related conditions while assessing their reusability. Our findings highlight both opportunities provided by open access available well any limitations associated with use. As AI increasingly relies high-quality, labelled data, barriers impeding sharing (such lack comprehensive documentation or adherence FAIR principles) must be addressed so leverage advanced deep models unlock new possibilities diagnosis analysis wide array conditions.
Язык: Английский
Процитировано
3
SLEEP Advances, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Abstract Despite extensive evidence on the roles of non-rapid eye movement (NREM) and REM sleep in memory processing, a comprehensive model that integrates their complementary functions remains elusive due to lack mechanistic understanding REM’s role offline processing. We present Refining Rescuing (RnR) Hypothesis, which posits principal function is increase signal-to-noise ratio within across representations. As such, selectively enhances essential nodes representation while inhibiting majority (Refine). Additionally, modulates weak strong representations so they fall similar range recallability (Rescue). Across multiple NREM-REM cycles, tuning individual traces get sharpened, allowing for integration shared features hypothesize sleep’s unique cellular, neuromodulatory, electrophysiological milieu, marked by greater inhibition mixed autonomic state both sympathetic parasympathetic activity, underpins these processes. The RnR Hypothesis offers unified framework explains diverse behavioral neural outcomes associated with sleep, paving way future research more sleep-dependent cognitive functions.
Язык: Английский
Процитировано
0
Infancy, Год журнала: 2025, Номер 30(1)
Опубликована: Янв. 1, 2025
ABSTRACT Current research indicates likely developmental connections between the evolution of sleep patterns, motor skills progression, and expansion vocabulary. These are grounded in well‐established role memory learning, as well cascading effects on language development acquisition new skills. However, no study has so far undertaken a comprehensive systematic examination these or explored their trajectory over time. Yet understanding vocabulary depends considering regulation domains, to provide biologically explanation how early lexicons built strengthened. This investigates links growth two significant changes occurring first 2 years life: self‐initiated locomotion consolidation overnight sleep. Our results reveal mutual associations which tend emerge during periods marked change language, skills, patterns regulation. Moreover, were observed time, suggesting dynamic interconnections domains. findings point toward importance investigating from systems perspective, product continuous interactions cognition, body environment.
Язык: Английский
Процитировано
0
Pediatric Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 20, 2025
Sleep parameters evolve in parallel with neurodevelopment. participates synaptic homeostasis and memory consolidation infant sleep correlate later aspects of early childhood cognition. Typically developing, term-born infants had a diurnal sleep-EEG at 4 months Griffiths III developmental assessment 18 months. EEG analysis included macrostructure (i.e. durations total stages, latencies to REM), spindle features, quantitative features (qEEG): interhemispheric connectivity spectral power. We assessed the correlations between these quotients. recordings from 92 were analyzed. latency was positively associated Foundations Learning subscale N3 duration correlated Personal-Social-Emotional subscale. synchrony negatively Eye Hand Coordination, Personal-Social-Emotional, Gross Motor, General Development Motor subscales. In some states, delta 1 2 power coherence measures Certain 4-month-old are neurodevelopment may be useful biomarkers This study shows that during provide insights into neurodevelopmental outcomes. have examined novel shown help predict elements such as sleep, duration, qEEG for future Due exceptional neuroplasticity infancy, support targeted intervention optimize
Язык: Английский
Процитировано
0
Progress in Neurobiology, Год журнала: 2025, Номер unknown, С. 102771 - 102771
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Опубликована: Апрель 29, 2025
SUMMARY MOTIVATION Long-term monitoring of behavioral and physiological processes is critical for understanding complex brain-based phenomena disorders that develop over extended periods, such as chronic stress, circadian disorders, metabolic conditions. While digital phenotyping available in humans using smart devices, there remains a deficit rodent models. To address this lack long-term phenotyping, we introduce the “Digital Homecage” (DHC) system. Our system uses accessible components designed seamless integration with brain recording technologies. The Digital Homecage allows uninterrupted, long-timescale more than 20 metrics single-housed mice, captured at sub-second resolution via video, operant interactions, wheel-running data. This report demonstrates DHC’s capacity to enable continuous, automated tracking behaviors like actigraphy, sleep, grooming, food choice options weeks, thereby opening up new avenues longitudinal analyses Data collected reveal patterns multiple spontaneous behaviors, aligning known nocturnal tendencies. system’s potential facilitate groundbreaking observations on correlates various neuropsychiatric syndromes aided by open-source software relatively low cost. DHC sets stage community-driven innovation, potentially transforming our approach studying traits function behavior laboratory settings.
Язык: Английский
Процитировано
0
Current Biology, Год журнала: 2022, Номер 32(18), С. 4025 - 4039.e3
Опубликована: Авг. 18, 2022
The maturation of sleep behavior across a lifespan (sleep ontogeny) is an evolutionarily conserved phenomenon. Mammalian studies have shown that in addition to increased duration, early life exhibits stark differences compared with mature regard states. How the intrinsic output circuits contributes ontogeny poorly understood. fruit fly Drosophila melanogaster multifaceted changes from juvenile adulthood. Here, we use non-invasive probabilistic approach investigate architecture and flies. Increased flies driven primarily by decreased probability transitioning wake characterized more time deeper Functional manipulations sleep-promoting neurons dorsal fan-shaped body (dFB) suggest these differentially regulate Transcriptomic analysis dFB at different ages subsequent RNAi screen implicate genes involved circuit maturation. These results reveal dynamic transcriptional states contribute lifespan.
Язык: Английский
Процитировано
13
Communications Biology, Год журнала: 2022, Номер 5(1)
Опубликована: Ноя. 29, 2022
Abstract During sleep our brain switches between two starkly different states - slow wave (SWS) and rapid eye movement (REM) sleep. While this two-state pattern is abundant across birds mammals, its existence in other vertebrates not universally accepted, evolutionary emergence unclear it undetermined whether a fundamental property of vertebrate brains or an adaptation specific to homeotherms. To address these questions, we conducted electrophysiological recordings the Agamid lizard, Laudakia vulgaris during We found clear signatures that resemble mammalian avian patterns. These switched periodically throughout night with cycle ~90 seconds were remarkably similar previously reported Pogona vitticeps . Interestingly, contrast high temperature sensitivity states, state robust large variations temperature. also breathing rate, micro-movements movements locked REM as they are mammals. Collectively, findings suggest agamid family, shares physiological similarity sleep, can be maintain poikilothems, increasing probability existed cold-blooded ancestor amniotes.
Язык: Английский
Процитировано
12
NeuroImage, Год журнала: 2024, Номер 286, С. 120508 - 120508
Опубликована: Янв. 4, 2024
Sleep plays a crucial role in brain development, sensory information processing, and consolidation. spindles are markers of these mechanisms as they mirror the activity thalamocortical circuits. Spindles can be subdivided into two groups, slow (10-13 Hz) fast (13-16 Hz), which each associated with different functions. Specifically, oscillate high-sigma band sensorimotor is affected by visual deprivation. However, how blindness influences spindle development has not yet been investigated. We recorded nap video-EEG 50 blind/severely visually impaired (BSI) 64 sighted children aged 5 months to 6 years old. considered aspects both macro- micro-structural spindles. The BSI lacked evolution developmental within central area. young presented low high-beta (25-30 event-related spectral perturbation showed no signs maturational decrease. High-sigma group correlated clinical indices predicting perceptual motor disorders. Our findings suggest that pivotal biomarkers for identifying an early deviation children. These critical initial therapeutic intervention.
Язык: Английский
Процитировано
2