The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster
,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
cholesterol-responsive
GRNs
comprise
a
subset
also
responds
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies'
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
Life,
Год журнала:
2025,
Номер
15(1), С. 110 - 110
Опубликована: Янв. 16, 2025
Chemosensation
and
mechanosensation
are
vital
to
insects’
survival
behavior,
shaping
critical
physiological
processes
such
as
feeding,
metabolism,
mating,
reproduction.
During
insects
rely
on
diverse
chemosensory
mechanosensory
receptors
distinguish
between
nutritious
harmful
substances,
enabling
them
select
suitable
food
sources
while
avoiding
toxins.
These
distributed
across
various
body
parts,
allowing
detect
environmental
cues
about
quality
adjust
their
behaviors
accordingly.
A
deeper
understanding
of
insect
sensory
physiology,
especially
during
not
only
enhances
our
knowledge
biology
but
also
offers
significant
opportunities
for
practical
applications.
This
review
highlights
recent
advancements
in
research
feeding-related
receptors,
covering
a
wide
range
species,
from
the
model
organism
Drosophila
melanogaster
agricultural
human
pests.
Additionally,
this
examines
potential
targeting
precision
pest
control.
Disrupting
feeding
reproduction
emerges
promising
strategy
management.
By
interfering
with
these
essential
behaviors,
we
can
effectively
control
populations
minimizing
impacts
promoting
ecological
balance.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
ABSTRACT
Artificial
sweeteners
are
highly
sweet,
non-nutritive
compounds
that
have
become
increasingly
popular
over
recent
decades
despite
research
suggesting
their
consumption
has
unintended
consequences.
Specifically,
there
is
evidence
some
of
these
chemicals
interact
with
bitter
taste
receptors,
implying
likely
generate
complex
chemosensory
signals.
Here,
we
report
the
basic
sensory
characteristics
in
Drosophila
,
a
common
model
system
used
to
study
impacts
diet,
and
find
all
noncaloric
inhibited
appetitive
feeding
responses
at
higher
concentrations.
At
cellular
level,
found
sucralose
rebaudioside
A
co-activated
sweet
gustatory
receptor
neurons
(GRNs),
two
populations
reciprocally
impact
behavior,
while
aspartame
only
activated
cells.
We
assessed
behavioral
co-activation
low
concentrations
signal
high
aversion.
Finally,
silencing
GRNs
reduced
aversive
elicited
by
significantly
increased
behaviors.
Together,
conclude
artificial
more
than
“sweetness”
alone,
this
behaviorally
relevant
effects
on
may
help
flies
flexibly
respond
unique
compounds.
The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster
,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
responsive
GRNs
comprise
a
subset
also
respond
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies’
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
cholesterol-responsive
GRNs
comprise
a
subset
also
responds
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies'
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster
,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
cholesterol-responsive
GRNs
comprise
a
subset
also
responds
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies'
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
