Converting an allocentric goal into an egocentric steering signal

Nature, Год журнала: 2024, Номер 626(8000), С. 808 - 818

Опубликована: Фев. 7, 2024

Neuronal signals that are relevant for spatial navigation have been described in many species

Язык: Английский

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A neural circuit architecture for rapid learning in goal-directed navigation

Neuron, Год журнала: 2024, Номер 112(15), С. 2581 - 2599.e23

Опубликована: Май 24, 2024

Anchoring goals to spatial representations enables flexible navigation but is challenging in novel environments when both must be acquired simultaneously. We propose a framework for how Drosophila uses internal of head direction (HD) build goal upon selective thermal reinforcement. show that flies use stochastically generated fixations and directed saccades express heading preferences an operant visual learning paradigm HD neurons are required modify these based on used symmetric setting expose flies' co-evolve the reliability interacting impacts behavior. Finally, we describe rapid new headings may rest behavioral policy whose parameters form genetically encoded circuit architecture. Such evolutionarily structured architectures, which enable rapidly adaptive behavior driven by representations, relevant across species.

Язык: Английский

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Neural circuit mechanisms for steering control in walkingDrosophila

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2020, Номер unknown

Опубликована: Апрель 5, 2020

Abstract Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Язык: Английский

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Flexible navigational computations in the Drosophila central complex

Current Opinion in Neurobiology, Год журнала: 2022, Номер 73, С. 102514 - 102514

Опубликована: Фев. 19, 2022

Язык: Английский

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Dopamine promotes head direction plasticity during orienting movements

Nature, Год журнала: 2022, Номер 612(7939), С. 316 - 322

Опубликована: Ноя. 30, 2022

Abstract In neural networks that store information in their connection weights, there is a tradeoff between sensitivity and stability 1,2 . Connections must be plastic to incorporate new information, but if they are too plastic, stored can corrupted. A potential solution allow plasticity only during epochs when task-specific rich, on the basis of ‘when-to-learn’ signal 3 We reasoned dopamine provides when-to-learn allows brain’s spatial maps update available—that is, an animal moving. Here we show neurons innervating Drosophila head direction network specifically active fly turns change its direction. Moreover, activity scales with moment-to-moment fluctuations rotational speed. Pairing release visual cue persistently strengthens cue’s influence cells. Conversely, inhibiting these decreases cue. This mechanism should accelerate learning moments orienting movements providing rich stream allowing rates low at other times protect information. Our results how brain compressed into discrete which high matched intake.

Язык: Английский

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The conserved RNA-binding protein Imp is required for the specification and function of olfactory navigation circuitry in Drosophila

Current Biology, Год журнала: 2024, Номер 34(3), С. 473 - 488.e6

Опубликована: Янв. 4, 2024

Complex behaviors depend on the precise developmental specification of neuronal circuits, but relationship between genetic programs for neural development, circuit structure, and behavioral output is often unclear. The central complex (CX) a conserved sensory-motor integration center in insects, which governs many higher-order largely derives from small number type II stem cells (NSCs). Here, we show that Imp, IGF-II mRNA-binding protein expressed NSCs, plays role specifying essential components CX olfactory navigation circuitry. We following: (1) multiple circuitry arise NSCs. (2) Manipulating Imp expression NSCs alters morphology these elements, with most potent effects neurons targeting ventral layers fan-shaped body (FB). (3) regulates Tachykinin-expressing FB input neurons. (4) required establishing proper neuropil structures. (5) Loss abolishes upwind orientation to attractive odor while leaving locomotion odor-evoked regulation movement intact. Taken together, our findings establish temporally gene can regulate behavior by developmentally regulating provides first step toward dissection its roles behavior.

Язык: Английский

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Neural circuit mechanisms for steering control in walking Drosophila

Опубликована: Ноя. 27, 2024

Orienting behaviors provide a continuous stream of information about an organism’s sensory experiences and plans. Thus, to study the links between sensation action, it is useful identify neurons in brain that control orienting behaviors. Here we describe descending Drosophila predict influence orientation (heading) during walking. We show these cells have specialized functions: whereas one cell type predicts sustained low-gain steering, other transient high-gain steering. These latter integrate internally-directed steering signals from head direction system with stimulus-directed multimodal pathways. The inputs are organized produce “see-saw” commands, so increasing output hemisphere accompanied by decreasing hemisphere. Together, our results internal external drives integrated motor commands different timescales, for flexible precise space.

Язык: Английский

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Neural representation of goal direction in the monarch butterfly brain

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Сен. 20, 2023

Neural processing of a desired moving direction requires the continuous comparison between current heading and goal direction. While neural basis underlying is well-studied, coding remains unclear in insects. Here, we used tetrode recordings tethered flying monarch butterflies to unravel how represented insect brain. recording, maintained robust directions relative virtual sun. By resetting their directions, found neurons whose spatial tuning was tightly linked directions. Importantly, unaffected when changed after compass perturbations, showing that these specifically encode Overall, here discovered invertebrate goal-direction share functional similarities cells reported mammals. Our results give insights into evolutionarily conserved principles goal-directed orientation animals.

Язык: Английский

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Coregistration of heading to visual cues in retrosplenial cortex

Nature Communications, Год журнала: 2023, Номер 14(1)

Опубликована: Апрель 8, 2023

Abstract Spatial cognition depends on an accurate representation of orientation within environment. Head direction cells in distributed brain regions receive a range sensory inputs, but visual input is particularly important for aligning their responses to environmental landmarks. To investigate how population-level heading are aligned input, we recorded from retrosplenial cortex (RSC) head-fixed mice moving environment using two-photon calcium imaging. We show that RSC neurons tuned the animal’s relative environment, even absence head movement. Next, found receives functionally distinct projections and thalamic areas contains several functional classes neurons. While some mirror newly discovered class coregisters signals. Finally, decoding analyses reveal unique contributions each class. Our results suggest circuit anchoring representations

Язык: Английский

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Fantastic beasts and how to study them: rethinking experimental animal behavior

Journal of Experimental Biology, Год журнала: 2024, Номер 227(4)

Опубликована: Фев. 15, 2024

ABSTRACT Humans have been trying to understand animal behavior at least since recorded history. Recent rapid development of new technologies has allowed us make significant progress in understanding the physiological and molecular mechanisms underlying behavior, a key goal neuroethology. However, there is tradeoff when studying its biological mechanisms: common protocols laboratory are designed be replicable controlled, but they often fail encompass variability breadth natural behavior. This Commentary proposes framework 10 questions that aim guide researchers incorporating rich context into their experimental design or choosing study system. The cover overarching considerations can provide template for interspecies comparisons, enable develop studies model organisms unlock experiments our quest

Язык: Английский

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