Cell Reports,
Год журнала:
2023,
Номер
42(10), С. 113297 - 113297
Опубликована: Окт. 1, 2023
Comparative
studies
of
related
but
ecologically
distinct
species
can
reveal
how
the
nervous
system
evolves
to
drive
behaviors
that
are
particularly
suited
certain
environments.
Drosophila
melanogaster
is
a
generalist
feeds
and
oviposits
on
most
overripe
fruits.
A
sibling
species,
D.
sechellia,
an
obligate
specialist
Morinda
citrifolia
(noni)
fruit,
which
rich
in
fatty
acids
(FAs).
To
understand
evolution
noni
taste
preference,
we
characterized
behavioral
cellular
responses
noni-associated
FAs
three
drosophilids.
We
find
mixtures
sugar
evoke
strong
aversion
not
sechellia.
Surveys
sensory
FA-
species-specific
differences
at
least
two
mechanisms—bitter
neuron
activation
sweet
inhibition–that
correlate
with
shifts
preference.
Chemoreceptor
mutant
analysis
predicts
multiple
genetic
changes
account
for
gustatory
preference
Taste
systems
encode
chemical
cues
that
drive
vital
behaviors.
We
have
elucidated
noncanonical
features
of
taste
coding
using
an
unconventional
kind
electrophysiological
analysis.
find
neurons
Drosophila
are
much
more
sensitive
than
previously
thought.
They
a
low
spontaneous
firing
frequency
depends
on
receptors.
dual
function
as
olfactory
neurons:
activated
by
most
tested
odorants,
including
N
,
-diethyl-
meta
-toluamide
(DEET),
at
distance.
DEET
can
also
inhibit
certain
neurons,
revealing
there
two
modes
response:
activation
and
inhibition.
characterize
OFF
responses
the
tastants
elicit
them
related
in
structure.
link
tastant
identity
to
behavior:
magnitude
response
elicited
correlated
with
egg
laying
behavior
it
elicited.
In
summary,
sensitivity
capacity
system
greater
known.
Nutritional Neuroscience,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Янв. 6, 2025
Purpose
The
incidence
of
obesity
has
surged
to
pandemic
levels
in
recent
decades.
Approximately
1.89
million
are
linked
excessive
salt
consumption.
This
study
aims
check
the
toxicity
at
different
concentrations
using
an
invertebrate
model
organism
Drosophila
melanogaster.
Life,
Год журнала:
2025,
Номер
15(1), С. 110 - 110
Опубликована: Янв. 16, 2025
Chemosensation
and
mechanosensation
are
vital
to
insects’
survival
behavior,
shaping
critical
physiological
processes
such
as
feeding,
metabolism,
mating,
reproduction.
During
insects
rely
on
diverse
chemosensory
mechanosensory
receptors
distinguish
between
nutritious
harmful
substances,
enabling
them
select
suitable
food
sources
while
avoiding
toxins.
These
distributed
across
various
body
parts,
allowing
detect
environmental
cues
about
quality
adjust
their
behaviors
accordingly.
A
deeper
understanding
of
insect
sensory
physiology,
especially
during
not
only
enhances
our
knowledge
biology
but
also
offers
significant
opportunities
for
practical
applications.
This
review
highlights
recent
advancements
in
research
feeding-related
receptors,
covering
a
wide
range
species,
from
the
model
organism
Drosophila
melanogaster
agricultural
human
pests.
Additionally,
this
examines
potential
targeting
precision
pest
control.
Disrupting
feeding
reproduction
emerges
promising
strategy
management.
By
interfering
with
these
essential
behaviors,
we
can
effectively
control
populations
minimizing
impacts
promoting
ecological
balance.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 6, 2025
ABSTRACT
Artificial
sweeteners
are
highly
sweet,
non-nutritive
compounds
that
have
become
increasingly
popular
over
recent
decades
despite
research
suggesting
their
consumption
has
unintended
consequences.
Specifically,
there
is
evidence
some
of
these
chemicals
interact
with
bitter
taste
receptors,
implying
likely
generate
complex
chemosensory
signals.
Here,
we
report
the
basic
sensory
characteristics
in
Drosophila
,
a
common
model
system
used
to
study
impacts
diet,
and
find
all
noncaloric
inhibited
appetitive
feeding
responses
at
higher
concentrations.
At
cellular
level,
found
sucralose
rebaudioside
A
co-activated
sweet
gustatory
receptor
neurons
(GRNs),
two
populations
reciprocally
impact
behavior,
while
aspartame
only
activated
cells.
We
assessed
behavioral
co-activation
low
concentrations
signal
high
aversion.
Finally,
silencing
GRNs
reduced
aversive
elicited
by
significantly
increased
behaviors.
Together,
conclude
artificial
more
than
“sweetness”
alone,
this
behaviorally
relevant
effects
on
may
help
flies
flexibly
respond
unique
compounds.
PLoS neglected tropical diseases,
Год журнала:
2025,
Номер
19(3), С. e0012877 - e0012877
Опубликована: Март 17, 2025
Chemical
repellents
against
arthropods
have
limitations
in
terms
of
toxicity
and
resistance.
Natural
plant
compounds
can
be
utilized
as
alternatives
for
developing
environmentally
friendly
humans
animals.
A
variety
essential
oils
exhibit
strong
repellent
effects
ticks;
however,
the
mechanisms
action
ticks
remain
unknown.
Here,
we
investigated
repellency
cinnamaldehyde,
a
primary
compound
found
cinnamon
oil,
demonstrated
that
it
affected
electrophysiological
responses
on
Haller’s
organs
parthenogenetic
Haemaphysalis
longicornis
.
Transcriptome
data
indicated
cinnamaldehyde
response
was
linked
to
ionotropic
receptor
(HL-IR)
at
various
tick
developmental
stages.
HL-IR
widely
expressed
tissues
stages
according
RT-qPCR.
In
situ
hybridization
results
showed
highly
ticks.
Microinjection
double-stranded
RNA
(dsRNA)
reduced
transcript
levels
led
significant
decreases
rate
from
EAG
organ.
Experiments
using
competitive
fluorescence
binding
mutation
sites
218ASN
critical
site
HL-IR.
We
conclude
organ
expresses
HL-IR,
this
interaction
mediates
tick-repellent
behavior
by
cinnamaldehyde.
The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster
,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
responsive
GRNs
comprise
a
subset
also
respond
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies’
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
cholesterol-responsive
GRNs
comprise
a
subset
also
responds
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies'
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
The
question
as
to
whether
animals
taste
cholesterol
is
not
resolved.
This
study
investigates
the
fruit
fly,
Drosophila
melanogaster
,
capable
of
detecting
through
their
gustatory
system.
We
found
that
flies
are
indifferent
low
levels
and
avoid
higher
levels.
avoidance
mediated
by
receptor
neurons
(GRNs),
demonstrating
can
cholesterol.
cholesterol-responsive
GRNs
comprise
a
subset
also
responds
bitter
substances.
Cholesterol
detection
depends
on
five
ionotropic
(IR)
family
members,
disrupting
any
these
genes
impairs
flies'
ability
Ectopic
expressions
IRs
in
reveals
two
classes
receptors,
each
with
three
shared
one
unique
subunit.
Additionally,
expressing
receptors
sugar-responsive
confers
attraction
cholesterol,
GRNs.
