Infrequent strong connections constrain connectomic predictions of neuronal function

Cell, Год журнала: 2025, Номер unknown

Опубликована: Июнь 1, 2025

Язык: Английский

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Rigid propagation of visual motion in the insect’s neural system

Neural Networks, Год журнала: 2024, Номер 181, С. 106874 - 106874

Опубликована: Ноя. 6, 2024

Язык: Английский

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WASPSYN: A Challenge for Domain Adaptive Synapse Detection in Microwasp Brain Connectomes

IEEE Transactions on Medical Imaging, Год журнала: 2024, Номер 43(11), С. 3719 - 3730

Опубликована: Май 13, 2024

The size of image volumes in connectomics studies now reaches terabyte and often petabyte scales with a great diversity appearance due to different sample preparation procedures. However, manual annotation neuronal structures (e.g., synapses) these huge is time-consuming, leading limited labeled training data smaller than 0.001% the large-scale application. Methods that can utilize in-domain generalize out-of-domain unlabeled are urgent need. Although many domain adaptation approaches proposed address such issues natural domain, few them have been evaluated on lack benchmarks. Therefore, enable developments adaptive synapse detection methods for applications, we annotated 14 from biologically diverse set Megaphragma viggianii brain regions originating three whole-brain datasets organized WASPSYN challenge at ISBI 2023. annotations include coordinates pre-synapses post-synapses 3D space, together their one-to-many connectivity information. This paper describes dataset, tasks, baseline, evaluation method, results challenge. Limitations impact neuroscience research also discussed. will continue be available https://codalab.lisn.upsaclay.fr/competitions/9169. Successful algorithms emerge our may potentially revolutionize real-world further cause aims unravel complexity structure function.

Язык: Английский

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Building a small brain with a simple stochastic generative model

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 4, 2024

The architectures of biological neural networks result from developmental processes shaped by genetically encoded rules, biophysical constraints, stochasticity, and learning. Understanding these is crucial for comprehending circuits’ structure function. ability to reconstruct circuits, even entire nervous systems, at the neuron synapse level, facilitates study design principles systems their plan. Here, we investigate developing connectome C. elegans using statistical generative models based on simple features: neuronal cell type, birth time, body distance, reciprocity, synaptic pruning. Our accurately predict existence, degree profiles individual neurons, statistics small network motifs. Importantly, require a surprisingly number types, which infer characterize. We further show that replicate experimentally-observed path, multiple epochs are necessary. Validation our model’s predictions connections reconstructions adult worms suggests model identified fundamental “backbone” connectivity graph. accuracy use here offers general framework studying how connectomes develop underlying design.

Язык: Английский

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The first complete 3D reconstruction and morphofunctional mapping of an insect eye

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 1, 2024

Abstract The structure of compound eyes in arthropods has been the subject many studies, revealing important biological principles. Until recently, these studies were constrained by two-dimensional nature available ultrastructural data. By taking advantage novel three-dimensional dataset obtained using volume electron microscopy (vEM), we present first cellular-level reconstruction whole eye an insect, miniaturized parasitoid wasp Megaphragma viggianii . female M. consists 29 ommatidia and contains 478 cells. Despite almost anucleate brain, all cells contain nuclei. As larger insects, dorsal rim area (DRA) that are believed to be specialized polarized light detection as reflected their corneal retinal morphology. We report presence three ‘ectopic’ photoreceptors. Our results offer new insights into miniaturization scaling sensory organs general.

Язык: Английский

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Comparative connectomics: Wiring diagram of a miniature insect compound eye

Current Biology, Год журнала: 2023, Номер 33(23), С. R1226 - R1228

Опубликована: Дек. 1, 2023

Язык: Английский

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