bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Ноя. 17, 2023
Abstract
Negative
memories
engage
a
brain
and
body-wide
stress
response
in
humans
that
can
alter
cognition
behavior.
Prolonged
responses
induce
maladaptive
cellular,
circuit,
systems-level
changes
lead
to
pathological
states
corresponding
disorders
which
mood
memory
are
affected.
However,
it’s
unclear
if
repeated
activation
of
cells
processing
negative
induces
similar
phenotypes
mice.
In
this
study,
we
used
an
activity-dependent
tagging
method
access
neuronal
ensembles
assess
their
molecular
characteristics.
Sequencing
engrams
mice
revealed
positive
(male-to-female
exposure)
(foot
shock)
upregulated
genes
linked
anti-
pro-inflammatory
responses,
respectively.
To
investigate
the
impact
persistent
engrams,
chemogenetically
activated
them
ventral
hippocampus
over
three
months
conducted
anxiety
memory-related
tests.
engram
increased
behaviors
both
6-
14-month-old
mice,
reduced
spatial
working
older
impaired
fear
extinction
younger
heightened
generalization
age
groups.
Immunohistochemistry
microglial
astrocytic
structure
number
hippocampus.
summary,
lasting
cellular
behavioral
abnormalities
offering
insights
into
effects
chronic
thinking-like
on
human
health.
Negative
memories
engage
a
brain
and
body-wide
stress
response
in
humans
that
can
alter
cognition
behavior.
Prolonged
responses
induce
maladaptive
cellular,
circuit,
systems-level
changes
lead
to
pathological
states
corresponding
disorders
which
mood
memory
are
affected.
However,
it
is
unclear
if
repeated
activation
of
cells
processing
negative
induces
similar
phenotypes
mice.
In
this
study,
we
used
an
activity-dependent
tagging
method
access
neuronal
ensembles
assess
their
molecular
characteristics.
Sequencing
engrams
mice
revealed
positive
(male-to-female
exposure)
(foot
shock)
upregulated
genes
linked
anti-
pro-inflammatory
responses,
respectively.
To
investigate
the
impact
persistent
engrams,
chemogenetically
activated
them
ventral
hippocampus
over
3
months
conducted
anxiety
memory-related
tests.
engram
increased
behaviors
both
6-
14-month-old
mice,
reduced
spatial
working
older
impaired
fear
extinction
younger
heightened
generalization
age
groups.
Immunohistochemistry
microglial
astrocytic
structure
number
hippocampus.
summary,
lasting
cellular
behavioral
abnormalities
offering
insights
into
effects
chronic
thinking-like
on
human
health.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Апрель 8, 2024
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
induces
immune-mediated
diseases.
Interactions
between
the
host
and
virus
govern
induction,
resulting
in
multiorgan
impacts.
In
2021,
as
normal
life
was
challenging
during
pandemic
era,
we
analyzed
SCI
journals
according
to
L.
Wittgenstein's
Tractatus
Logi-co-Philosophicus.
The
pathophysiology
of
disease
2019
(COVID-19)
involves
following
steps:
1)
angiotensin-converting
enzyme
(ACE2)
Toll-like
receptor
(TLR)
pathways:
2)
neuropilin
(NRP)
pathway,
with
seven
papers
continuing
twenty-four:
3)
sterile
alpha
motif
(SAM)
histidine-aspartate
domain
(HD)-containing
protein
1
(SAMHD1)
tetramerization
two
twelve:
4)
inflammasome
activation
pathways,
five
thirteen:
5)
cytosolic
DNA
sensor
cyclic-GMP-AMP
synthase
(cGAS)/stimulator
interferon
genes
(STING)
(cGAS–STING)
signaling
six
successful
eleven:
6)
spike
fourteen
twenty-three:
7)
immunological
memory
engram
thirteen
successive
eighteen:
8)
excess
acetylcholine
three
nine.
We
reconfirmed
that
COVID-19
(1-7)
pathways
a
new
pathway
involving
acetylcholine.
Therefore,
it
is
necessary
therapeutically
alleviate
block
pathological
course
harmoniously
modulating
innate
lymphoid
cells
(ILCs)
if
diverse
SARS-CoV-2
variants
are
subsequently
encountered
future.
Philosophical Transactions of the Royal Society B Biological Sciences,
Год журнала:
2024,
Номер
379(1906)
Опубликована: Июнь 10, 2024
Rodents
actively
learn
new
motor
skills
for
survival
in
reaction
to
changing
environments.
Despite
the
classic
view
of
primary
cortex
(M1)
as
a
simple
muscle
relay
region,
it
is
now
known
play
significant
role
skill
acquisition.
The
secondary
(M2)
reported
be
crucial
region
learning
well
its
execution
and
planning.
Although
these
two
regions
are
part
they
learning,
direct
connection
synaptic
correlates
between
remains
elusive.
Here,
we
confirm
M2
M1
connectivity
with
series
tracing
experiments.
We
also
show
that
accelerating
rotarod
task
successfully
induces
acquisition
mice.
For
mice
underwent
training,
learner
showed
increased
density
spine
head
size
synapses
activated
cell
populations
M1.
Non-learner
did
not
changes.
Collectively,
data
suggest
potential
importance
plasticity
mechanism
learning.
This
article
discussion
meeting
issue
‘Long-term
potentiation:
50
years
on’.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 12, 2024
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
induces
immune-mediated
diseases.
Interactions
between
the
host
and
virus
govern
induction,
resulting
in
multiorgan
impacts
In
2021,
as
normal
life
was
challenging
during
pandemic
era,
we
analyzed
SCI
journals
according
to
L.
Wittgenstein's
Tractatus
Logi-co-Philosophicus.
The
pathophysiology
of
disease
2019
(COVID-19)
involves
1)
angiotensin-converting
enzyme
(ACE2)
Toll-like
receptor
(TLR)
pathways
starting
with
eight,
from
2022.01.14.,
rediscovered
nineteen,
2024.01.10.,
2)
neuropilin
(NRP)
pathway
seven
successful
twenty
four,
3)
sterile
alpha
motif
(SAM)
histidine-aspartate
domain
(HD)-containing
protein
1
(SAMHD1)
tetramerization
two
thirteen,
4)
inflammasome
activation
five
5)
cytosolic
DNA
sensor
cyclic-GMP-AMP
synthase
(cGAS)/stimulator
interferon
genes
(STING)
(cGAS–STING)
signaling
six
eleven,
6)
spike
fourteen
three,
7)
immunological
memory
engram
thirteen
eighteen,
8)
excess
acetylcholine
three
nine.
We
reconfirmed
that
COVID-19
involved
(1–7)
a
new
involving
acetylcholine.
Therefore,
it
is
necessary
therapeutically
alleviate
block
pathological
course
harmoniously
modulating
innate
lymphoid
cells
(ILCs)
if
subsequent
diverse
SARS-CoV-2
variants
are
encountered
future.
