DAMM for the detection and tracking of multiple animals within complex social and environmental settings

Scientific Reports, Год журнала: 2024, Номер 14(1)

Опубликована: Сен. 12, 2024

Язык: Английский

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Calcium/calmodulin-dependent protein kinase II α and β differentially regulate mammalian sleep

Communications Biology, Год журнала: 2025, Номер 8(1)

Опубликована: Янв. 5, 2025

While sleep is important, our understanding of its molecular mechanisms limited. Over the last two decades, protein kinases including Ca2+/calmodulin-dependent kinase II (CaMKII) α and β have been implicated in regulation. Of all known mouse genetic mutants, biggest changes reported to be observed adult mice with sgRNAs for Camk2b injected into their embryos: reduced by approximately 120 min (mins) over 24 h (hrs). We reexamined phenotype either Camk2a or gene knocked-out conventional targetting. basal knockout mice, it remains unaltered mutants. Knockout reduces rebound after deprivation, indicating roles homeostasis. These results indicate involvement CaMKIIα both homeostasis while CaMKIIβ mainly required physiologically homeostasis, serving as a stimulus rigorous studies future. Sleep analysis stable transgenic strains reveals homeostatic rebound, that but not sleep.

Язык: Английский

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Actualités de 2024 en recherche fondamentale

Médecine du Sommeil, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

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Distinct Effects of Olanzapine Depot Treatment on Behavior and Muscarinic M1 Receptor Expression in the Triple‐Hit Wisket Rat Model of Schizophrenia

Genes Brain & Behavior, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 23, 2025

ABSTRACT This study aimed to characterize the triple‐hit schizophrenia‐like model rats (Wisket) by assessment of (1) behavioral parameters in different test conditions (reward‐based Ambitus and HomeManner system) for a prolonged period, (2) cerebral muscarinic M1 receptor (M1R) expression, (3) effects olanzapine treatment on these parameters. Wistar (control) Wisket were injected three consecutive weeks with depot (100 mg/kg) spent 4 large cages environmental enrichment (HomeManner). The vehicle‐treated longer time awake decreased grooming activity compared controls, without changes their active social behavior (sniffing, playing, fighting) obtained HomeManner. Olanzapine most parameters, only passive interaction (huddling during sleeping) enhanced mostly injection day, which recovered within days. In test, showed lower locomotor exploratory activities impaired cognition control rats, deteriorating both groups. brain samples, M1R mRNA expression was significantly cortex elevated hippocampus, no difference prefrontal versus control. normalized hippocampal but it cortex. had characteristics acute reward‐based undisturbed circumstances investigated periods, altered expression. Chronic resulted deterioration some group, could restore few negative signs rats.

Язык: Английский

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Actualités de 2024 en santé du sommeil

Médecine du Sommeil, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

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Food intake enhances hippocampal sharp wave-ripples

Опубликована: Янв. 27, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body's state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding-when need increases, if so, feeding-dependent modulation communicated other regions regulation-remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Язык: Английский

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A bench-to-bedside narrative review of the sleep-social-oxytocin nexus.

Sleep Medicine Reviews, Год журнала: 2025, Номер 81, С. 102077 - 102077

Опубликована: Фев. 28, 2025

Язык: Английский

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Food intake enhances hippocampal sharp wave-ripples

Опубликована: Апрель 3, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding– when need increases, if so, feeding-dependent modulation communicated other regions regulation, remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Язык: Английский

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Food intake enhances hippocampal sharp wave-ripples

eLife, Год журнала: 2025, Номер 14

Опубликована: Апрель 14, 2025

Effective regulation of energy metabolism is critical for survival. Metabolic control involves various nuclei within the hypothalamus, which receive information about body’s state and coordinate appropriate responses to maintain homeostasis, such as thermogenesis, pancreatic insulin secretion, food-seeking behaviors. It has recently been found that hippocampus, a brain region traditionally associated with memory spatial navigation, also involved in metabolic regulation. Specifically, hippocampal sharp wave-ripples (SWRs), are high-frequency neural oscillations supporting consolidation foraging decisions, have shown reduce peripheral glucose levels. However, whether SWRs enhanced by recent feeding—when need increases, if so, feeding-dependent modulation communicated other regions regulation—remains unknown. To address these gaps, we recorded from dorsal CA1 hippocampus mice during sleep sessions before after consumption meals varying caloric values. We occurring significantly following food intake, magnitude enhancement being dependent on content meal. This pattern occurred under both food-deprived ad libitum feeding conditions. Moreover, demonstrate GABAergic neurons lateral known regulate exhibit robust SWR-triggered increase activity. These findings identify satiety factor modulating suggest hippocampal-lateral hypothalamic communication potential mechanism could modulate intake.

Язык: Английский

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From social effort to social behavior: An integrated neural model for social motivation

Neuroscience & Biobehavioral Reviews, Год журнала: 2025, Номер unknown, С. 106170 - 106170

Опубликована: Апрель 1, 2025

Язык: Английский

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