The sociality of sleep in animal groups

Trends in Ecology & Evolution, Год журнала: 2024, Номер unknown

Опубликована: Сен. 1, 2024

Язык: Английский

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Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Communications Biology, Год журнала: 2024, Номер 7(1)

Опубликована: Сен. 20, 2024

Social thermoregulation is a means of maintaining homeostatic body temperature. While adult mice are model organism for studying both social behavior and energy regulation, the relationship between huddling core temperature (Tb) poorly understood. Here, we develop behavioral paradigm computational tools to identify active-huddling quiescent-huddling as distinct thermal substates. We find that an effective thermoregulatory strategy in female but not male groups. At 23 °C (room temperature), 30 (near thermoneutrality), facilitates large reductions Tb Tb-variance. Notably, associated with bidirectional changes Tb, depending on its proximity bouts quiescent-huddling. Further, group-housed animals lacking synaptic scaffolding gene Shank3b have hyperthermic spend less time huddling. In contrast, individuals cold-sensing Trpm8 hypothermic - deficit rescued by increased time. These results reveal how acute adjustments state-dependent manner.

Язык: Английский

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Neural basis of collective social behavior during environmental challenge

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 19, 2024

ABSTRACT Humans and animals have a remarkable capacity to collectively coordinate their behavior respond environmental challenges. However, the underlying neurobiology remains poorly understood. Here, we found that groups of mice self-organize into huddles at cold ambient temperature during thermal challenge assay. We make active (self-initiated) passive (partner-initiated) decisions enter or exit huddle. Using microendoscopic calcium imaging, are encoded distinctly within dorsomedial prefrontal cortex (dmPFC). Silencing dmPFC activity in some reduced decision-making, but also induced compensatory increase by non-manipulated partners, conserving group’s overall huddle time. These findings reveal how collective is implemented neurobiological mechanisms meet homeostatic needs

Язык: Английский

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Oxytocin neurons signal state-dependent transitions to thermogenesis and behavioral arousal in social and non-social settings.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Окт. 22, 2024

Abstract Mammalian thermoregulatory behaviors such as thermal comfort seeking, physical activity, nesting, and huddling operate alongside autonomic responses brown fat thermogenesis peripheral vasodilation to defend core body temperature (Tb) 1–4 . The defended Tb is not held constant, but alternates across active/rest behavioral cycles 5–9 Although the facilitating these alternations are controlled by brain, underlying neural populations poorly understood. oxytocin system has been proposed contribute thermoregulation 10,11 , yet evidence for how activity within neurons relates pathways lacking. Here, we identify neuronal dynamics in mice. We show that paraventricular hypothalamus (PVN) PVN (PVN OT ) selectively activated during two states: active quiescent huddling. Next, activation inhibition of reveals effects on Tb, vasodilation, warm establishing a role thermoeffector pathways. then demonstrate vivo calcium tracks patterning behaviors. Across social contexts, peaks occur low (∼36.0°C) transitions towards thermogenesis. In solo context, predict offset quiescence onset post-quiescence nesting. paired post-quiescent Our study provides rest arousal foundation understanding coordination between homeostasis animal behavior. Graphical

Язык: Английский

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Adolescent sleep and its disruption in depression and anxiety

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Ноя. 7, 2024

Adolescence is a pivotal stage during development when one’s personality, emotion, and behavioral traits are shaped to great extent, the underlying neural circuits undergo substantial developmental organizations. Dramatic dynamic changes occur in sleep architecture throughout postnatal course. Insufficient disruption of sleep/wake coherence prevalent among adolescents worldwide, even so young patients with neuropsychiatric conditions. Although accumulating evidence has suggested tight association between depression/anxiety, causal relationship remains largely unclear. More importantly, most these studies focused on adult subjects, little known about role mood behavior. Here we review recent investigating acute chronic effects adolescent depression anxiety both humans rodent models focuses assessment methodology age. By discussing findings unsolved problems, hope achieve better understanding mental health provide insights for future research.

Язык: Английский

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DAMM for the detection and tracking of multiple animals within complex social and environmental settings

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Янв. 20, 2024

Accurate detection and tracking of animals across diverse environments are crucial for behavioral studies in various disciplines, including neuroscience. Recently, machine learning computer vision techniques have become integral to the neuroscientist's toolkit, enabling high-throughput studies. Despite advancements localizing individual simple environments, task remains challenging complex conditions due intra-class visual variability environmental diversity. These limitations hinder ethologically-relevant conditions, such as when concealed within nests or obscured environments. Moreover, current tools laborious time-consuming employ, requiring extensive, setup-specific annotation model training/validation procedures. To address these challenges, we introduce 'Detect Any Mouse Model' (DAMM), a pretrained object detector mice capable robust performance with zero minimal additional training on new experimental setups. Our approach involves collecting annotating dataset that encompasses single multi-housed lighting setups, occlusion levels. We utilize Mask R-CNN architecture instance segmentation validate DAMM's no data (zero-shot inference) few examples fine-tuning (few-shot inference). DAMM excels zero-shot inference, detecting mice, even rats, entirely unseen scenarios further improves training. By integrating SORT algorithm, demonstrate tracking, competitively performing keypoint-estimation-based methods. Finally, advance simplify studies, made accessible scientific community user-friendly Python API, shared weights, Google Colab implementation.

Язык: Английский

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The role of ultradian rhythms in post-deprivation rebounds and diurnal rhythms of sleep and wakefulness in rats

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 5, 2024

Abstract The temporal organization of ultradian rhythms in sleep and wakefulness during post-sleep deprivation (TSD) rebound were investigated 15 rats under contant bright light (LL). Following baseline recordings, subjected to TSD using gentle manual stimulation. Post-TSD rebounds cumulative (WAKE), rapid eye movement (REM) non-REM (NREM) analyzed WAKE-dominant (υ w ) sleep-dominant s phases. Rebounds WAKE NREM present only when data on a full cycle basis, absent υ phases alone. These approximately 50% complete not proportional excess/deficit. REM cycles partially expressed but . fully compensated for deficit. mediated mainly by reduction the duration phase, decreased probability arousal phase. mechanisms also found mediate diurnal 10 12:12 h LD cycle. This study implicates an timing mechanism control post-TSD suggests that all three states are adjustments WAKE-promoting mechanisms. Ultradian should be taken into account avoid errors analysis. Highlights Sleep-wake state exhibits circadian rhythms. interact with after deprivation. Circadian amplitude timing. Arousal-related processes these sleep-wake patterns both states. Measuring is necessary accurate analysis data.

Язык: Английский

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