Nervous system–wide analysis of all C. elegans cadherins reveals neuron-specific functions across multiple anatomical scales

Science Advances, Год журнала: 2025, Номер 11(8)

Опубликована: Фев. 21, 2025

Differential expression of cell adhesion proteins is a hallmark cell-type diversity across the animal kingdom. Gene family-wide characterization their organismal and function is, however, lacking. Using genome-engineered reporter alleles, we established an atlas entire set 12 cadherin gene family members in nematode Caenorhabditis elegans, revealing differential neuronal classes, dichotomy between broadly narrowly expressed cadherins, several context-dependent temporal transitions development. Engineered mutant null alleles cadherins were analyzed for defects morphology, behavior, soma positions, neurite neighborhood topology fasciculation, localization synapses many parts nervous system. This analysis revealed restricted pattern differentiation at discrete subsets anatomical scales, including novel role experience-dependent electrical synapse formation. In total, our results previously little explored perspectives on deployment function.

Язык: Английский

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Expanding ligand-receptor interaction networks for axon guidance: Structural insights into signal crosstalk and specificity

Current Opinion in Neurobiology, Год журнала: 2025, Номер 92, С. 102999 - 102999

Опубликована: Март 20, 2025

Guidance of nascent axons to their targets is mediated by attractive and repulsive cues that activate receptors on the axonal growth cone. The number ligand-receptor interactions implicated in axon pathfinding still expanding, large-scale cell-surface extracellular protein interactome studies have revealed extensive crosstalk between signaling axes once thought act independently. This raises question how apparent promiscuity molecular compatible with specific outcomes effects cone steering. Structural provided insights into modularity binding shown capacity engage multiple ligands. Here, we review recent findings about complexity interaction networks for guidance, structures complexes reveal mechanisms may specify output.

Язык: Английский

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Neural circuit assembly: A sticky cue that connects neurons with a preference for hue

Current Biology, Год журнала: 2025, Номер 35(7), С. R255 - R258

Опубликована: Апрель 1, 2025

Язык: Английский

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BC-PMJRS: A Brain Computing-inspired Predefined Multimodal Joint Representation Spaces for enhanced cross-modal learning

Neural Networks, Год журнала: 2025, Номер unknown, С. 107449 - 107449

Опубликована: Апрель 1, 2025

Язык: Английский

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Biased cell adhesion organizes the Drosophila visual motion integration circuit

Developmental Cell, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Nervous system-wide analysis of all C. elegans cadherins reveals neuron-specific functions across multiple anatomical scales

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 8, 2024

Differential expression of cell adhesion proteins is a hallmark type diversity across the animal kingdom. Gene family-wide characterization their organismal and function are, however, lacking. We established an atlas entire set 12 cadherin gene family members in nematode C. elegans, testing hypothesis that this define combinatorial codes may drive nervous system assembly. This reveals differential genomically tagged genes neuronal classes, dichotomy between broadly- narrowly-expressed cadherins, several context-dependent temporal transitions development. Engineered mutant null alleles cadherins were analyzed for defects morphology, behavior, soma positions, neurite neighborhood topology fasciculation, localization synapses many parts system. analysis revealed restricted pattern differentiation at discrete subsets anatomical scales, including novel role experience-dependent electrical synapse formation. In total, our results perspectives on deployment function.

Язык: Английский

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Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

The brain can represent almost limitless objects to "categorize an unlabeled world" (Edelman, 1989). This feat is supported by expansion layer circuit architectures, in which neurons carrying information about discrete sensory channels make combinatorial connections onto much larger postsynaptic populations. Combinatorial layers are modeled as randomized sets. extent wiring exists vivo debated, and how connectivity patterns generated during development not understood. Non-deterministic algorithms could program such using minimal genomic information. Here, we investigate anatomic transcriptional perturb partner availability ask Kenyon cells, the of insect mushroom body, obtain input from olfactory projection neurons. Olfactory form their presynaptic outputs orderly, predictable, biased fashion. We find that cells accept spatially co-located but molecularly heterogeneous inputs this orderly map, cell surface molecule expression impacts choice. Cell immunoglobulins broadly depleted propose allows them with partners. model explain developmentally identical acquire diverse identities.

Язык: Английский

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Growing Artificial Neural Networks for Control: the Role of Neuronal Diversity

Proceedings of the Genetic and Evolutionary Computation Conference Companion, Год журнала: 2024, Номер unknown, С. 175 - 178

Опубликована: Июль 14, 2024

Язык: Английский

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