Chemistry & Biodiversity,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
ABSTRACT
This
study
investigated
the
effects
of
8,12‐dimethoxysanguinarine
(DSG)
from
Eomecon
chionantha
Hance
on
malignant
biological
activity
breast
cancer
cells.
RNA‐sequencing
measure
analysis
revealed
that
metastasis‐related
genes
were
significantly
downregulated
in
DSG‐treated
MCF‐7
DSG
inhibits
migration
ability
Molecular
docking
studies
demonstrated
significant
interactions
between
and
Fibronectin
1
(FN1)
protein,
with
a
binding
energy
‐8.91
kcal/mol.
Additionally,
FN1
messenger
RNA
expression
was
upregulated
1085
tumor
samples
compared
to
normal
tissue
Cancer
Genome
Atlas
Breast
Invasive
Carcinoma
Collection
dataset.
also
suppressed
cell
metastasis
by
downregulating
expression.
Furthermore,
identified
as
promising
candidate
based
absorption
distribution
metabolism
excretion
toxicity
drug‐likeness
assessments.
Combination
indicated
synergized
conventional
chemotherapeutic
agent
doxorubicin
suppress
migration,
confirmed
wound‐healing
transwell
assays.
Collectively,
these
findings
suggest
may
serve
potential
for
inhibiting
decreasing
Plants,
Год журнала:
2025,
Номер
14(1), С. 122 - 122
Опубликована: Янв. 3, 2025
This
ethnobotanical
study
examines
the
traditional
knowledge
and
usage
patterns
of
wild
plants
in
western
Alps,
specifically
within
Ubaye
Bellino
Valleys,
through
a
comparative
analysis
data
collected
from
1983
(published
1990)
to
2024.
Our
aims
assess
change
plant
usage,
species
diversity,
changing
roles
local
traditions
Alpine
mountain
ecosystems.
While
survey
documented
medicinal
uses
centered
around
pastoralist
practices,
2024
highlight
notable
increase
use
synanthropic
plants,
now
utilized
both
medicinally
as
food.
Several
such
Allium
sativum,
Artemisia
absinthium,
Urtica
dioica
have
shown
resilience
continuity
cultural
maintaining
medicinal,
culinary,
ritual
significance
across
four
decades.
The
greatest
variety
(101),
number
that
decreased
subsequent
studies.
2009
identified
36
not
previously
recorded
1983,
field
noted
an
additional
20
species.
highlights
economic
potential
several
these
alpine
areas,
Achillea,
Artemisia,
Verbascum,
Veronica,
Viola,
Polygonum,
Bunium,
Sorbus
spp.,
which
could
be
for
creating
new
herbal
teas,
artisanal
beers,
liqueurs,
ice
creams,
sweets,
seasoned
food
products.
Expanding
only
preserve
but
also
stimulate
economies
support
sustainable
development
communities.
temporal
shifts
reflect
broader
cultural,
ecological,
socio-economic
changes,
underscoring
importance
preserving
biodiversity
amidst
ongoing
environmental
societal
shifts.
underlines
need
conserve
heritage
while
adapting
evolving
landscape
region.
Future
research
focus
on
exploring
role
sustainability
initiatives,
including
conservation
strategies,
ecosystem
services,
community-based
tourism
continuing
document
dynamics
influencing
usage.
Frontiers in Plant Science,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 9, 2025
As
an
efficient
gene
editing
tool,
the
CRISPR/Cas9
system
has
been
widely
employed
to
investigate
and
regulate
biosynthetic
pathways
of
active
ingredients
in
medicinal
plants.
CRISPR
technology
holds
significant
potential
for
enhancing
both
yield
quality
By
precisely
regulating
expression
key
enzymes
transcription
factors,
not
only
deepens
our
understanding
secondary
metabolic
plants
but
also
opens
new
avenues
drug
development
modernization
traditional
Chinese
medicine.
This
article
introduces
principles
its
efficacy
editing,
followed
by
a
detailed
discussion
applications
metabolism
includes
examination
composition
implementation
strategies
within
pathways,
as
well
influence
Cas9
protein
variants
advanced
systems
field.
In
addition,
this
examines
long-term
impact
on
progress
plant
research
development.
It
raises
existing
issues
research,
including
off-target
effects,
complexity
genome
structure,
low
transformation
efficiency,
insufficient
pathways.
At
same
time,
puts
forward
some
insights
order
provide
ideas
subsequent
application
summary,
presents
broad
prospects
study
is
poised
facilitate
further
advancements
biomedicine
agricultural
science.
technological
continue
challenges
are
progressively
addressed,
expected
play
increasingly
vital
role
European Journal of Nutrition & Food Safety,
Год журнала:
2025,
Номер
17(1), С. 136 - 144
Опубликована: Янв. 15, 2025
Background
to
the
Study:
The
increasing
prevalence
of
malnutrition
and
micronutrient
deficiencies,
particularly
in
developing
countries,
necessitates
development
affordable,
nutrient-dense
foods.
Aim:
This
study
aim
develop
evaluate
nutritional
sensory
properties
peanut
butter
fortified
with
moringa
leaf
powder
enhance
its
macronutrient
composition
for
addressing
malnutrition.
Place
Duration
Conducted
dietetics
kitchen
Department
Human
Nutrition
Dietetics,
Lead
City
University,
Ibadan,
Oyo
State,
Nigeria,
between
February
May
2024
Methodology:
Peanut
was
prepared
using
roasted
groundnuts
varying
levels
powder.
A
70:30
ratio
applied
seeds
respectively.
standard
methods,
including
sorting,
roasting,
de-hulling,
grinding,
fortification.
Nutritional
analyses
were
conducted
determine
proximate
(protein,
fat,
fiber,
ash,
carbohydrate)
(iron,
potassium,
zinc,
vitamin
B6,
A).
Sensory
evaluation
performed
a
9-point
hedonic
scale
assess
taste,
texture,
color,
overall
acceptability.
Data
analyzed
ANOVA
Statistical
Package
Social
Sciences
(SPSS)
Version
22.0,
differences
means
considered
significant
at
p
<
0.05.
Results:
results
showed
improvements
compared
control.
Protein,
fiber
product
26.23
±
0.08%,
52.66
0.01%,
4.87
0.03%,
respectively,
24.84
0.06%,
50.68
4.35
0.01%
Fortification
also
enhanced
levels,
iron
zinc
from
5.25
0.02
mg/100
g
3.24
0.03
control
7.14
4.80
product.
indicated
higher
scores
color
but
slightly
lower
flavor
texture
samples
(p
<0.05).
Conclusion:
Fortifying
significantly
enhances
profile,
iron,
A.
presents
viable,
cost-effective
intervention
combating
resource-limited
regions.
emphasizes
potential
large-scale
production
highlights
need
further
research
on
consumer
acceptability
shelf
stability.
Horticulturae,
Год журнала:
2025,
Номер
11(2), С. 185 - 185
Опубликована: Фев. 8, 2025
Echinophora
platyloba
DC.
(Apiaceae)
is
recognized
for
its
important
secondary
metabolites
and
antifungal
agents.
To
evaluate
the
effects
of
macronutrient
fertilizers
on
growth
parameters
essential
oils
yield
E.
platyloba,
a
study
was
conducted
in
2018
at
Shahrekord
University,
Iran.
The
treatments
included
individual
combined
application
nitrogen,
phosphorus,
potassium,
along
with
control
groups.
results
revealed
that
nitrogen
significantly
influenced
biomass
accumulation
stems,
leaves,
inflorescences,
phosphorus-treated
plants
showing
notable
increase
leaf
weight.
Compared
to
positive
control,
phosphorus
increased
oil
by
488%,
while
enhanced
165%.
primary
compounds
identified
(E)-β-ocimene,
(E)-sesquilavandolol,
β-pinene,
percentages
ranging
between
21.3–32.1%,
14.1–42.0%,
2.0–8.8%,
respectively.
levels
γ-decalactone,
spathulenol
were
found
be
higher
potassium
than
nitrogen.
In
contrast,
limonene,
linalool,
geraniol,
(E)-sesquilavandulol
concentrations
greater
treatment
compared
treatments.
conclusion,
fertilization
can
substantially
other
treatments,
potentially
enhancing
production
per
unit
area,
which
supports
farmers’
income
helps
prevent
degradation
this
species
natural
habitats.
Review
Ethnopharmacological
and
Medicinal
Properties
of
Allophylus
dimorphus
Radlk.:
An
Update
Md
Nasir
Ahmed
1,
Azazahemad
A.
Kureshi
2,*,
Chowdhury
Alfi
Afroze
3,
Emran
Habibi
4,5,
Satyajit
D.
Sarker
5,
Lutfun
Nahar
6,*
1
Biotechnology
&
Natural
Medicine
Division,
TechB
Nutrigenomics,
Dhaka
1207,
Bangladesh
2
Analytical
Development
Innovation
Center,
Pharmanza
Herbal
Pvt.
Ltd.,
Anand
388435,
Gujarat,
India
3
Department
Genetic
Engineering,
University
Alternative,
1209,
4
Plants
Research
Centre,
Institute
Medicines
Metabolic
Disorders,
Mazandaran
Medical
Sciences,
Sari
48157-33971,
Iran
5
Centre
for
Products
Discovery
(CNPD),
School
Pharmacy
Biomolecular
Liverpool
John
Moores
University,
James
Parsons
Building,
Byrom
Street,
L3
3AF,
UK
6
Laboratory
Growth
Regulators,
Palacký
Experimental
Botany,
The
Czech
Academy
Šlechtitelů
27,
78371
Olomouc,
Republic
*
Correspondence:
[email protected]
(A.A.K.);
[email protected]
(L.N.)
Received:
February
2025;
Revised:
7
March
Accepted:
10
Published:
12
2025
Abstract:
Radlk.,
a
member
the
Sapindaceae
family,
is
shrub
or
tree
primarily
found
in
Nicobar
Islands,
Malaysia,
Philippines.
Despite
its
potential
relevance
traditional
medicine,
research
on
ethnopharmacological
medicinal
properties
this
species
currently
limited.
However,
few
closely
related
species,
such
as
cobbe
serratus,
have
been
studied
their
bioactive
compounds
with
antioxidant,
antimicrobial,
anti-inflammatory
properties.
World
Health
Organization
(WHO)
recognizes
significance
which
remains
vital
healthcare
source
many
communities
worldwide.
rapid
loss
plant
diversity
discovering
novel
highlight
necessity
documenting
investigating
species.
This
update
consolidates
existing
knowledge
phytochemistry,
ethnomedicinal
uses,
pharmacological
dimorphus,
providing
foundation
future
conservation
efforts.
Toxins,
Год журнала:
2025,
Номер
17(3), С. 139 - 139
Опубликована: Март 14, 2025
Mycotoxin
contamination
in
medicinal
plants
can
lead
to
toxicity,
reduced
therapeutic
efficacy,
and
economic
losses.
This
has
emerged
as
a
significant
issue,
drawing
attention
from
researchers
research
centers
worldwide.
Over
recent
decades,
numerous
analytical
studies
have
addressed
mycotoxin
these
herbs,
evaluating
various
methods
determine
their
presence
quantitatively
qualitatively.
While
several
reviews
summarized
studies,
they
often
overlook
comprehensive
exploration
of
the
mechanisms
influencing
factors
herbs.
Therefore,
this
review
aims
delve
into
aflatoxin
ochratoxin
some
most
widespread
including
jujube
fruits,
lotus
seeds,
licorice
roots.
The
were
also
examined,
physical
composition
maturity
stages
concluded
that
A
herbs
involves
complex
interactions
between
herbs’
natural
defenses,
fungal
pathogenicity,
chemical
composition,
characteristics,
individual
plant
differences
at
stages.
Understanding
contamination,
association
with
maturity,
nutrient
profile,
development,
advances
our
comprehension
Journal of Humanistic Psychology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Peak
and
mystical
experiences
can
be
seen
as
states
of
consciousness
that
exist
on
a
spectrum
varying
intensity
duration.
They
are
often
described
moments
profound
joy,
ecstasy,
awe
involve
feelings
noetic
quality,
decreased
self-salience,
heightened
interconnectedness.
The
renewed
interest
in
psychedelics
potential
tool
for
therapeutic
intervention
has
been
driven
by
early
observations
the
role
peak
promoting
well-being
healing.
Numerous
studies
have
shown
direct
correlation
between
strength
positive,
long-lasting
psychological
outcomes
achieved
with
psychedelic
psychotherapy
across
range
mental
health
conditions,
including
depression,
cancer-related
distress,
substance
use
disorders.
mechanisms
underlying
this
effect
complex
neurobiological
changes,
particularly
brain
regions
associated
self-referential
processing
consciousness.
However,
medicalization
psychedelic-assisted
therapy
raises
critical
questions
about
ability
to
commodify
these
transformative
states.
This
prompts
reevaluation
important
underscores
their
importance
achieving
benefits
attained
through
emerging
approach.
As
result,
further
exploration
non-pharmacological
means
inducing
benefit
is
warranted.
The
use
of
herbaria
for
science
and
conservation
is
revolutionizing
the
discovery,
exploration,
protection
biodiversity
at
unprecedented
scopes
scales.
Global
Metaherbarium—a
digitally
interlinked,
open-access
resource—is
stimulating
these
efforts
helping
to
facilitate
massive
investigations
that
utilize
aggregated
digital
derivatives
physical
herbarium
specimens.
Simultaneously,
growing
this
virtual
resource
expanding
collections
by
researchers
from
many
scholarly
domains
who
increasingly
are
sampling
specimens
multiomic
(e.g.,
genomics,
transcriptomics,
metabolomics,
proteomics,
microbiomics).
These
leading
new
scientific
insights
supporting
development
actions,
but
they
come
with
a
substantial
cost:
(partial)
destruction
priceless
often
irreplaceable
specimens,
which
constitute
global
heritage
should
be
permanently
safeguarded
future
reference.
absence
comprehensive
set
“best
practices”
destructively
leads
confusion
uncertainty
institutions
alike
risks
over-exploitation
precious
when
research
executed.
Here,
we
provide
best
practices
aimed
reducing
uncertainties
creating
framework
sustainably
ethically
Our
recommendations
intended
two
complementary
overlapping
audiences—users
stewards—who
together
build,
use,
protect
collections.