Unveiling 8,12‐dimethoxysanguinarine: A Potent Inhibitor of Breast Cancer Metastasis via FN1 Downregulation DOI

Xiuli Xi,

Yuxin Qi,

Mingli Zhang

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

ABSTRACT This study investigated the effects of 8,12‐dimethoxysanguinarine (DSG) from Eomecon chionantha Hance on malignant biological activity breast cancer cells. RNA‐sequencing measure analysis revealed that metastasis‐related genes were significantly downregulated in DSG‐treated MCF‐7 DSG inhibits migration ability Molecular docking studies demonstrated significant interactions between and Fibronectin 1 (FN1) protein, with a binding energy ‐8.91 kcal/mol. Additionally, FN1 messenger RNA expression was upregulated 1085 tumor samples compared to normal tissue Cancer Genome Atlas Breast Invasive Carcinoma Collection dataset. also suppressed cell metastasis by downregulating expression. Furthermore, identified as promising candidate based absorption distribution metabolism excretion toxicity drug‐likeness assessments. Combination indicated synergized conventional chemotherapeutic agent doxorubicin suppress migration, confirmed wound‐healing transwell assays. Collectively, these findings suggest may serve potential for inhibiting decreasing

Язык: Английский

Unveiling 8,12‐dimethoxysanguinarine: A Potent Inhibitor of Breast Cancer Metastasis via FN1 Downregulation DOI

Xiuli Xi,

Yuxin Qi,

Mingli Zhang

и другие.

Chemistry & Biodiversity, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

ABSTRACT This study investigated the effects of 8,12‐dimethoxysanguinarine (DSG) from Eomecon chionantha Hance on malignant biological activity breast cancer cells. RNA‐sequencing measure analysis revealed that metastasis‐related genes were significantly downregulated in DSG‐treated MCF‐7 DSG inhibits migration ability Molecular docking studies demonstrated significant interactions between and Fibronectin 1 (FN1) protein, with a binding energy ‐8.91 kcal/mol. Additionally, FN1 messenger RNA expression was upregulated 1085 tumor samples compared to normal tissue Cancer Genome Atlas Breast Invasive Carcinoma Collection dataset. also suppressed cell metastasis by downregulating expression. Furthermore, identified as promising candidate based absorption distribution metabolism excretion toxicity drug‐likeness assessments. Combination indicated synergized conventional chemotherapeutic agent doxorubicin suppress migration, confirmed wound‐healing transwell assays. Collectively, these findings suggest may serve potential for inhibiting decreasing

Язык: Английский

Процитировано

0