Epithelial cell competition is promoted by signaling from immune cells DOI Creative Commons
Yilun Zhu, Zeba Wunderlich, Arthur D. Lander

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 18, 2025

Abstract In epithelial tissues, juxtaposition of cells different phenotypes can trigger cell competition, a process whereby one type drives death and extrusion another. During growth homeostasis, competition is thought to serve quality control function, eliminating that are “less fit”. Tissues may also attack eliminate newly arising tumor cells, exploiting mechanisms shared with other instances but differ, reportedly, in the involvement immune system. Whereas have been shown play direct role killing this has not observed cases suggesting tissues recognize handle cancer differently. Here, we challenge view, showing that, fruit fly Drosophila , innate similar roles during classical as tumors. These findings suggest suppression exploit same involved promoting phenotypic uniformity among cells.

Язык: Английский

Extraembryonic gut endoderm cells undergo programmed cell death during development DOI Creative Commons
Júlia Batki, Sara Hetzel, Dennis Schifferl

и другие.

Nature Cell Biology, Год журнала: 2024, Номер 26(6), С. 868 - 877

Опубликована: Июнь 1, 2024

Despite a distinct developmental origin, extraembryonic cells in mice contribute to gut endoderm and converge transcriptionally resemble their embryonic counterparts. Notably, all progenitors share non-canonical epigenome, raising several pertinent questions, including whether this landscape is reset match the regulation if persist into later development. Here we developed two-colour lineage-tracing strategy track isolate over time. We find that display substantial memory of origin retention original DNA methylation resulting transcriptional signatures. Furthermore, show undergo programmed cell death neighbouring clear remnants via non-professional phagocytosis. By midgestation, no longer detect wild-type gut, whereas they differentiate further p53-mutant embryos. Our study provides key insights molecular fate inside embryo.

Язык: Английский

Процитировано

4
Drosophila Toll-2 controls homeotic domain formation and timing of folding DOI Open Access

Lale Alpar,

Rémi Pigache, Adrien Leroy

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Tissue compartmentalization is a fundamental feature of animal development, crucial for determining cell fate, growth, and organ morphogenesis. Hox genes play essential conserved roles in specifying homeotic compartments along the antero-posterior axis body. Despite extensive characterization gene regulation, mechanisms underlying formation, maintenance, reshaping during development remain incompletely understood. Here, we investigate role Toll-2 receptor formation folding Deformed (Dfd) compartment, which produces neck adult Drosophila . We show that properly forming bilateral Dfd compartment through fusion two eye-antennal imaginal discs. Additionally, find regulates timing morphogenesis by promoting apoptosis cell-cell rearrangements preceding folding. Last, establish independently sequentially governs both its via PI3K Src signaling, respectively. Altogether, our findings provide novel insights into spatiotemporal regulation development.

Язык: Английский

Процитировано

0
Epithelial cell competition is promoted by signaling from immune cells DOI Creative Commons
Yilun Zhu, Zeba Wunderlich, Arthur D. Lander

и другие.

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 18, 2025

Abstract In epithelial tissues, juxtaposition of cells different phenotypes can trigger cell competition, a process whereby one type drives death and extrusion another. During growth homeostasis, competition is thought to serve quality control function, eliminating that are “less fit”. Tissues may also attack eliminate newly arising tumor cells, exploiting mechanisms shared with other instances but differ, reportedly, in the involvement immune system. Whereas have been shown play direct role killing this has not observed cases suggesting tissues recognize handle cancer differently. Here, we challenge view, showing that, fruit fly Drosophila , innate similar roles during classical as tumors. These findings suggest suppression exploit same involved promoting phenotypic uniformity among cells.

Язык: Английский

Процитировано

0