Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells DOI Creative Commons

Wanyu Lei,

Damon A. Clark, Jonathan B. Demb

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(49)

Опубликована: Ноя. 27, 2024

Orientation is one of the most salient features in visual scenes. Neurons at multiple levels system detect orientation, but many cases, underlying biophysical mechanisms remain unresolved. Here, we studied for orientation detection earliest stage system, B/K wide-field amacrine cells (B/K WACs), a group giant, nonspiking interneurons mouse retina that coexpress Bhlhe22 (B) and Kappa Opioid Receptor (K). WACs exhibit orientation-tuned calcium signals along their long, straight, unbranching dendrites, which contain both synaptic inputs outputs. Simultaneous dendritic imaging somatic voltage recordings reveal individual dendrites are electrotonically isolated, exhibiting spatially confined yet extended receptive field dendrite, term “compartmentalized pooling.” Further, WAC dendrite exhibits center-surround antagonism. Phenomenological models demonstrate compartmentalized pooling generates selectivity, antagonism shapes band-pass spatial frequency tuning. At microcircuit level, receive excitation driven by contrast polarity (e.g., “ON”) glycinergic inhibition opposite “OFF”). However, this “crossover” not essential generating selectivity. A minimal model reproduced from feedforward excitatory combined with substantial increase specific membrane resistance between compartments. Collectively, our results mechanism selectivity WACs, enriching understanding diverse strategies employed throughout to orientation.

Язык: Английский

Development and organization of the retinal orientation selectivity map DOI Creative Commons
Dominic J. Vita,

Fernanda S. Orsi,

Nathan G. Stanko

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Июнь 6, 2024

Abstract Orientation or axial selectivity, the property of neurons in visual system to respond preferentially certain angles stimuli, plays a pivotal role our understanding perception and information processing. This computation is performed as early retina, although much work has established cellular mechanisms retinal orientation how this organized across retina unknown. Using large dataset collected mouse we demonstrate functional organization rules selectivity. First, identify three major classes cells that are selective match previous descriptions. Second, show one predominantly represented predominant changes function location. Third, neural activity little on Lastly, use silico modeling followed by validation experiments overrepresented aligns along concentric axes. These results that, similar direction selectivity map retina.

Язык: Английский

Процитировано

7
Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus DOI Open Access

Yue Fei,

Michelle Luh,

Ashley Ontiri

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

Multiple sources innervate the visual thalamus to influence image-forming vision prior cortex, yet it remains unclear how non-retinal and retinal input coordinate shape thalamic selectivity. Using dual-color two-photon calcium imaging in of awake mice, we observed similar coarse-scale retinotopic organization between axons superior colliculus neurons ganglion cells, both providing strong converging excitatory neurons. At a fine scale ∼10 µm, collicular boutons often shared feature preferences with nearby boutons. Inhibiting significantly suppressed responses specifically reduced motion selectivity preferring nasal-to-temporal motion. The reduction could be result silencing sharply tuned direction-selective colliculogeniculate input. These findings suggest that is not merely relay but selectively integrates inputs from multiple regions build stimulus information transmitted cortex. Chronic reveals diverse tuning axonal boutons.Nearby share at µm scaleSilencing suppresses majority neurons.Silencing reduces

Язык: Английский

Процитировано

0
A spherical code of retinal orientation selectivity enables decoding in ensembled and retinotopic operation DOI Creative Commons
Dimitrios Daniel Laniado, Yariv Maron,

John A. Gemmer

и другие.

Cell Reports, Год журнала: 2025, Номер 44(3), С. 115373 - 115373

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Dendritic Architecture Enables de Novo Computation of Salient Motion in the Superior Colliculus DOI Creative Commons
Norma K. Kühn, Chen Li,

Natalia Baimacheva

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Dendritic architecture plays a crucial role in shaping how neurons extract behaviorally relevant information from sensory inputs. Wide-field the superior colliculus integrate visual retina to encode cues critical for visually guided orienting behaviors. However, principles governing these filter their inputs generate appropriate responses remain unclear. Using viral tracing, two-photon calcium imaging, and computational modeling, we show that wide-field receive functionally diverse twelve retinal ganglion cell types, forming layered, type-specific organization along dendrites. This structured arrangement allows multiplex salient motion cues, selectively amplifying movement suppressing static features. Computational models reveal spatial of dendrites enables selective extraction stimuli, including de novo computations. Our findings underscore dendritic processing neural circuit function.

Язык: Английский

Процитировано

0
Development and Organization of the Retinal Orientation Selectivity Map DOI Open Access
Dominic J. Vita,

Fernanda S. Orsi,

Nathan G. Stanko

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Март 28, 2024

Abstract Orientation or axial selectivity, the property of neurons in visual system to respond preferentially certain angles a stimuli, plays pivotal role our understanding perception and information processing. This computation is performed as early retina, although much work has established cellular mechanisms retinal orientation how this organized across retina unknown. Using large dataset collected mouse we demonstrate functional organization rules selectivity. First, identify three major classes cells that are selective match previous descriptions. Second, show one predominantly represented predominant changes function location. Third, neural activity little on Lastly, use silico modeling followed by validation experiments overrepresented aligns along concentric axes. These results that, similar direction selectivity map retina. One Sentence Summary Development

Язык: Английский

Процитировано

1
Compartmentalized pooling generates orientation selectivity in wide-field amacrine cells DOI Creative Commons

Wanyu Lei,

Damon A. Clark, Jonathan B. Demb

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 121(49)

Опубликована: Ноя. 27, 2024

Orientation is one of the most salient features in visual scenes. Neurons at multiple levels system detect orientation, but many cases, underlying biophysical mechanisms remain unresolved. Here, we studied for orientation detection earliest stage system, B/K wide-field amacrine cells (B/K WACs), a group giant, nonspiking interneurons mouse retina that coexpress Bhlhe22 (B) and Kappa Opioid Receptor (K). WACs exhibit orientation-tuned calcium signals along their long, straight, unbranching dendrites, which contain both synaptic inputs outputs. Simultaneous dendritic imaging somatic voltage recordings reveal individual dendrites are electrotonically isolated, exhibiting spatially confined yet extended receptive field dendrite, term “compartmentalized pooling.” Further, WAC dendrite exhibits center-surround antagonism. Phenomenological models demonstrate compartmentalized pooling generates selectivity, antagonism shapes band-pass spatial frequency tuning. At microcircuit level, receive excitation driven by contrast polarity (e.g., “ON”) glycinergic inhibition opposite “OFF”). However, this “crossover” not essential generating selectivity. A minimal model reproduced from feedforward excitatory combined with substantial increase specific membrane resistance between compartments. Collectively, our results mechanism selectivity WACs, enriching understanding diverse strategies employed throughout to orientation.

Язык: Английский

Процитировано

1