Predictive acoustical processing in human cortical layers

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract In our dynamic environments, predictive processing is vital for auditory perception and its associated behaviors. Predictive coding formalizes inferential processes by implementing them as information exchange across cortical layers areas. With laminar-specific blood oxygenation level dependent we measured responses to a cascading oddball paradigm, ground on the mesoscopic human architecture. We show that violation of predictions are potentially hierarchically organized with in superficial planum polare middle lateral temporal cortex. Moreover, relate updating brain’s internal model changes deep layers. Using modeling approach, derive putative neural dynamics while accounting draining effects. Our results support role architecture implementation highlight ability laminar fMRI investigate large extent

Язык: Английский

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The Origin of Human Theory-of-Mind

Humans, Год журнала: 2025, Номер 5(1), С. 5 - 5

Опубликована: Фев. 12, 2025

Is there a qualitative difference between apes’ and humans ‘ability to estimate others’ mental states’, a.k.a. ‘Theory-of-Mind’? After opting for the idea that expectations are empty profiles recognize particular content when it arrives, I apply same description ‘vicarious expectations’—very probably present in apes. Thus, (empty) vicarious one’s (full) contents distinguished without needing meta-representation. Then, propose: First, enough support Theory-of-Mind (including ‘spontaneous altruism’). Second, since require profile previously built subject activates them, this cannot activate any expectation of states intrinsically impossible him. Third, your think me as distal individual me, therefore, must contents. This ability (the original nucleus human Theory-of-Mind) is essential lifestyle. It involved unpleasant pleasant self-conscious emotions, which respectively contribute ‘social order’ cultural innovations. More basically, makes possible (prelinguistic or linguistic) communication, originally made understanding addressed therefore me.

Язык: Английский

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A hierarchical multiscale model of forward and backward alpha-band traveling waves in the visual system

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 15, 2024

Abstract Recent studies have shown that low-frequency oscillations in the cortex are often organized as traveling waves. The dynamical properties of these waves, span different scales, been linked to both sensory processing and cognitive functions. In EEG recordings, alpha-band (∼10Hz) waves propagate predominantly directions occipital-frontal axis, with forward being most prominent during visual processing, while backward dominate at rest suppression. While a previous study has proposed functional model explain their generation propagation, multi-scale, biologically plausible implementation is still lacking. Here, we present multi-scale network mean-field dynamics that, building on known interlaminar cortico-cortical projections, reproduces observed recordings. We show scalp-level can arise from two distinct sub-networks connected infragranular layers each area. At rest, generates spontaneous switches state upon bottom-up stimulation, reproducing recordings healthy participants.. then expand our cortico-thalamic parallel feedforward pathway through pulvinar. Our results this biases cortical high pulvinar engagement leads without external input. This result line suggesting key role for directing information flow cortex, provide computational basis investigate dynamics. summary, provides architecture modeling macroscale Importantly, bridges gap between scales by connecting laminar activity spatial patterns scalp level, providing grounded comprehensive view propagation

Язык: Английский

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Dissociable dynamic effects of expectation during statistical learning

Опубликована: Дек. 18, 2024

The brain is thought to generate internal predictions, based on previous statistical regularities in the environment, optimise behaviour. Predictive processing has been repeatedly demonstrated and seemingly explains expectation suppression (ES), or attenuation of neural activity response expected stimuli. However, mechanisms behind ES are unclear various models supporting have suggested with conflicting evidence. Sharpening propose that expectations suppress neurons not tuned stimulus, increasing signal-to-noise ratio for In contrast, dampening posit stimuli, relative amplitude unexpected Previous studies used decoding analyses examine these effects, increases accuracy interpreted terms sharpening decreases related dampening. opposing process theory (OPT) both processes may occur at different time points, namely initial followed by later representations stimulus as learning progresses. this study we aim test shed light dynamics single trial level over time. Thirty-one participants completed a task consisting paired scene categories whereby “leading” image from one category quickly “trailing” category. Multivariate EEG focussed information trailing Within-trial, showed increased early latencies decreased latencies, line OPT. across trials, trials trials. We theorise dissociable effects within can be explained context hierarchical mechanisms. Our results provide evidence OPT, while our suggest emerge stages learning.

Язык: Английский

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Predictive processing: Layer-specific prediction error signals in human cortex

Current Biology, Год журнала: 2024, Номер 34(10), С. R496 - R498

Опубликована: Май 1, 2024

Язык: Английский

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Dissociable dynamic effects of expectation during statistical learning.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 5, 2024

Abstract The brain is thought to generate internal predictions, based on previous statistical regularities in the environment, optimise behaviour. Predictive processing has been repeatedly demonstrated and seemingly explains expectation suppression (ES), or attenuation of neural activity response expected stimuli. However, mechanisms behind ES are unclear various models supporting have suggested with conflicting evidence. Sharpening propose that expectations suppress neurons not tuned stimulus, increasing signal-to-noise ratio for In contrast, dampening posit stimuli, relative amplitude unexpected Previous studies used decoding analyses examine these effects, increases accuracy interpreted terms sharpening decreases related dampening. opposing process theory (OPT) both processes may occur at different time points, namely initial followed by later representations stimulus as learning progresses. this study we aim test shed light dynamics single trial level over time. Thirty-one participants completed a task consisting paired scene categories whereby “leading” image from one category quickly “trailing” category. Multivariate EEG focussed information trailing Within-trial, showed increased early latencies decreased latencies, line OPT. across trials, trials trials. We theorise dissociable effects within can be explained context hierarchical mechanisms. Our results provide evidence OPT, while our suggest emerge stages learning.

Язык: Английский

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Expectations about presence enhance the influence of content-specific expectations on low-level orientation judgements

Cognition, Год журнала: 2024, Номер 254, С. 105961 - 105961

Опубликована: Сен. 20, 2024

Язык: Английский

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RDoC Framework Through the Lens of Predictive Processing: Focusing on Cognitive Systems Domain

Computational Psychiatry, Год журнала: 2024, Номер 8(1), С. 178 - 201

Опубликована: Янв. 1, 2024

In response to shortcomings of the current classification system in translating discoveries from basic science clinical applications, NIMH offers a new framework for studying mental health disorders called Research Domain Criteria (RDoC). This holds multidimensional outlook on psychopathologies focusing functional domains behavior and their implementing neural circuits. parallel, Predictive Processing (PP) stands as leading theory human brain function, offering unified explanation various types information processing brain. While both frameworks share an interest based pathophysiology, integration still needs be explored. Here, we argued favor explanatory power PP groundwork RDoC matrix validating its constructs creating testable hypotheses about mechanistic interactions between molecular biomarkers traits. Together, predictive may serve foundation achieving goals framework.

Язык: Английский

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Structural and functional alterations in different types of delusions across schizophrenia spectrum: A systematic review

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2024, Номер 136, С. 111185 - 111185

Опубликована: Окт. 31, 2024

Язык: Английский

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Dissociable dynamic effects of expectation during statistical learning

Опубликована: Дек. 18, 2024

The brain is thought to generate internal predictions, based on previous statistical regularities in the environment, optimise behaviour. Predictive processing has been repeatedly demonstrated and seemingly explains expectation suppression (ES), or attenuation of neural activity response expected stimuli. However, mechanisms behind ES are unclear various models supporting have suggested with conflicting evidence. Sharpening propose that expectations suppress neurons not tuned stimulus, increasing signal-to-noise ratio for In contrast, dampening posit stimuli, relative amplitude unexpected Previous studies used decoding analyses examine these effects, increases accuracy interpreted terms sharpening decreases related dampening. opposing process theory (OPT) both processes may occur at different time points, namely initial followed by later representations stimulus as learning progresses. this study we aim test shed light dynamics single trial level over time. Thirty-one participants completed a task consisting paired scene categories whereby “leading” image from one category quickly “trailing” category. Multivariate EEG focussed information trailing Within-trial, showed increased early latencies decreased latencies, line OPT. across trials, trials trials. We theorise dissociable effects within can be explained context hierarchical mechanisms. Our results provide evidence OPT, while our suggest emerge stages learning.

Язык: Английский

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