Transcriptomic DN3 clock neuron subtypes regulate Drosophila sleep
Science Advances,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 3, 2025
Circadian
neurons
within
animal
brains
orchestrate
myriad
physiological
processes
and
behaviors,
but
the
contribution
of
these
to
regulation
sleep
is
not
well
understood.
To
address
this
deficiency,
we
leveraged
single-cell
RNA
sequencing
generate
a
comprehensive
census
transcriptomic
cell
types
Drosophila
clock
neurons.
We
focused
principally
on
enigmatic
DN3s,
which
constitute
most
fly
brain
were
previously
almost
completely
uncharacterized.
These
DN3s
are
organized
into
12
clusters
with
unusual
gene
expression
features
compared
more
well-studied
further
show
that
uncharacterized
DN3
subtypes
promote
through
G
protein–coupled
receptor,
TrissinR
.
Our
findings
indicate
an
intricate
behavior
by
highlight
their
remarkable
diversity
in
functional
properties.
Язык: Английский
The Trissin/TrissinR signaling pathway in the circadian network regulates evening activity in Drosophila melanogaster under constant dark conditions
Biochemical and Biophysical Research Communications,
Год журнала:
2024,
Номер
704, С. 149705 - 149705
Опубликована: Фев. 22, 2024
Язык: Английский
A review of symptom, pathogenesis and treatment characteristics of the elderly with chronic insomnia
Medicine,
Год журнала:
2025,
Номер
104(5), С. e41346 - e41346
Опубликована: Янв. 31, 2025
One
third
of
a
person's
life
is
in
state
sleep,
and
good
sleep
quality
one
the
indicators
health.
Long-term
insomnia
has
great
impact
on
patients'
life,
physical
mental
state.
Especially
elderly,
long-term
will
induce
variety
chronic
diseases,
seriously
affecting
life.
Because
characteristics
physiological
structure
elderly
its
unique
different
from
that
young.
This
article
reviews
terms
symptom,
pathogenesis
treatment.
By
elaborating
senile
insomnia,
we
hope
to
provide
ideas
for
clinical
treatment
insomnia.
Язык: Английский
Regulation of pre-dawn arousal in Drosophila by a pair of trissinergic descending neurons of the visual and circadian networks
Current Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
The Cell-Intrinsic Circadian Clock is Dispensable for Lateral Posterior Clock Neuron Regulation of Drosophila Rest-Activity Rhythms
Neurobiology of Sleep and Circadian Rhythms,
Год журнала:
2025,
Номер
unknown, С. 100124 - 100124
Опубликована: Апрель 1, 2025
Язык: Английский
Differential regulation of sleep by blue, green, and red light in Drosophila melanogaster
Frontiers in Behavioral Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Окт. 30, 2024
Exposure
to
blue-enriched
light
from
electronic
devices
is
an
emergent
disruptor
of
human
sleep,
especially
at
particular
times
day.
Further
dissection
this
phenomenon
necessitates
modeling
in
a
tractable
model
organism.
Язык: Английский