Integrating and fragmenting memories under stress and alcohol

Neurobiology of Stress, Год журнала: 2024, Номер 30, С. 100615 - 100615

Опубликована: Фев. 8, 2024

Stress can powerfully influence the way we form memories, particularly extent to which they are integrated or situated within an underlying spatiotemporal and broader knowledge architecture. These different representations in turn have significant consequences for use these memories guide later behavior. Puzzlingly, although stress has historically been argued promote fragmentation, leading disjoint memory representations, more recent work suggests that also facilitate binding integration. Understanding circumstances under fosters integration will be key resolving this discrepancy unpacking mechanisms by shape Here, examine at multiple levels: linking together content of individual experience, threading associations between related but distinct events, experience into a pre-existing schema sense causal structure. We discuss neural cognitive each as well findings regarding how stress, aversive learning, negative affect modulate each. In analysis, uncover indeed level show may apply understanding effects alcohol, highlighting extant clinical preclinical opportunities further investigation. Finally, consider implications fragmentation memory-guided behavior, importance type representation is potentiated order design appropriate interventions.

Язык: Английский

The ventral hippocampus mediates experience-dependent social modulation of fear in rats

Pharmacology Biochemistry and Behavior, Год журнала: 2025, Номер unknown, С. 174016 - 174016

Опубликована: Апрель 1, 2025

Язык: Английский

Characterization of Neural Networks Involved in Transdiagnostic Emotion Dysregulation from a Pilot Randomized Controlled Trial of a Neurostimulation-Enhanced Behavioral Intervention

Psychiatry Research Neuroimaging, Год журнала: 2024, Номер 345, С. 111891 - 111891

Опубликована: Сен. 5, 2024

Язык: Английский