Single-cell synaptome mapping: its technical basis and applications in critical period plasticity research

Frontiers in Neural Circuits, Год журнала: 2024, Номер 18

Опубликована: Дек. 11, 2024

Our brain adapts to the environment by optimizing its function through experience-dependent cortical plasticity. This plasticity is transiently enhanced during a developmental stage, known as “critical period,” and subsequently maintained at lower levels throughout adulthood. Thus, understanding mechanism underlying critical period crucial for improving adaptability across lifespan. Critical relies on activity-dependent circuit remodeling anatomical functional changes individual synapses. However, it remains challenging identify molecular signatures of synapses responsible understand how these plasticity-related are spatiotemporally organized within neuron. Recent advances in genetic tools genome editing methodologies have enabled single-cell endogenous protein labeling brain, allowing comprehensive profiling neuron, namely “single-cell synaptome mapping.” promising approach can facilitate insights into spatiotemporal organization that sparse yet functionally important single neurons. In this review, we introduce basics mapping discuss applications investigate synaptic cellular mechanisms period.

Язык: Английский

A population-based analysis of the global burden of epilepsy across all age groups (1990–2021): utilizing the Global Burden of Disease 2021 data

Frontiers in Neurology, Год журнала: 2024, Номер 15

Опубликована: Дек. 12, 2024

To investigate the trends in epilepsy prevalence, incidence, mortality, and disability-adjusted life-years (DALYs) all ages, with risk factors for - associated death, from 1990 to 2021.

Язык: Английский