bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown
Опубликована: Фев. 12, 2025
Retinal ganglion cells (RGCs) transmit visual information from the eye to brain. In mice, several RGC subtypes show nonuniform spatial distributions, potentially mediating specific functions. However, full extent of specialization remains unknown. Here, we used en-face cryosectioning, transcriptomics, and machine learning map distribution all identified in previous single-cell studies. While two-thirds were evenly distributed, others showed strong biases toward ventral or dorso-temporal regions associated with sky vision area retinae temporalis (ART), predicted homolog centralis. Additionally, observed unexpected variation gene expression within along dorso-ventral axis vs. outside ART, independent density profiles. Finally, found limited correlations between profiles ART primate macula, suggesting divergent mouse central vision.
Язык: Английский