Basic Research in Cardiology,
Год журнала:
2024,
Номер
119(1), С. 1 - 33
Опубликована: Янв. 3, 2024
Despite
the
advances
in
treatment
options,
cardiovascular
disease
(CVDs)
remains
leading
cause
of
death
over
world.
Chronic
inflammatory
response
and
irreversible
fibrosis
are
main
underlying
pathophysiological
causes
progression
CVDs.
In
recent
decades,
cardiac
macrophages
have
been
recognized
as
regulatory
players
development
these
complex
conditions.
Numerous
approaches
aimed
at
devised,
to
novel
prospects
for
therapeutic
interventions.
Our
review
covers
advancements
macrophage-centric
plans
various
pathologic
conditions
examines
potential
consequences
obstacles
employing
macrophage-targeted
techniques
diseases.
Cellular & Molecular Biology Letters,
Год журнала:
2022,
Номер
27(1)
Опубликована: Окт. 4, 2022
Abstract
Long
noncoding
RNAs
are
involved
in
epigenetic
gene
modification,
including
binding
to
the
chromatin
rearrangement
complex
pre-transcriptional
regulation
and
promoters
expression
regulation,
as
well
acting
microRNA
sponges
control
messenger
RNA
levels
post-transcriptional
regulation.
An
increasing
number
of
studies
have
found
that
long
plasmacytoma
variant
translocation
1
(PVT1)
plays
an
important
role
cancer
development.
In
this
review
a
large
on
PVT1,
we
PVT1
is
closely
related
tumor
onset,
proliferation,
invasion,
epithelial–mesenchymal
transformation,
apoptosis,
poor
prognosis
radiotherapy
chemotherapy
resistance
some
cancers.
This
comprehensively
describes
various
cancers
presents
novel
approaches
diagnosis
treatment
cancer.
Journal of Inflammation Research,
Год журнала:
2022,
Номер
Volume 15, С. 4275 - 4290
Опубликована: Июль 1, 2022
Abstract:
Sepsis
is
an
abnormal
condition
with
multiple
organ
dysfunctions
caused
by
the
uncontrolled
infection
response
and
one
of
major
diseases
that
seriously
hang
over
global
human
health.
Besides,
sepsis
characterized
high
morbidity
mortality,
especially
in
intensive
care
unit
(ICU).
Among
numerous
subsequent
injuries
sepsis,
myocardial
injury
most
common
complications
main
cause
death
septic
patients.
To
better
manage
inpatients,
it
necessary
to
understand
specific
mechanisms
induced
(SIMI).
Therefore,
this
review
will
elucidate
pathophysiology
SIMI
from
following
certain
mechanisms:
apoptosis,
mitochondrial
damage,
autophagy,
excessive
inflammatory
response,
oxidative
stress
pyroptosis,
outline
current
therapeutic
strategies
potential
approaches
SIMI.
Keywords:
injury,
mechanism,
signaling
pathway
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(5), С. 2670 - 2670
Опубликована: Фев. 25, 2024
Over
the
past
century,
molecular
biology’s
focus
has
transitioned
from
proteins
to
DNA,
and
now
RNA.
Once
considered
merely
a
genetic
information
carrier,
RNA
is
recognized
as
both
vital
element
in
early
cellular
life
regulator
complex
organisms.
Long
noncoding
RNAs
(lncRNAs),
which
are
over
200
bases
long
but
do
not
code
for
proteins,
play
roles
gene
expression
regulation
signal
transduction
by
inducing
epigenetic
changes
or
interacting
with
various
RNAs.
These
interactions
exhibit
range
of
functions
cell
types,
including
macrophages.
Notably,
some
macrophage
lncRNAs
influence
activation
NF-κB,
crucial
transcription
factor
governing
immune
inflammatory
responses.
Macrophage
NF-κB
instrumental
progression
pathological
conditions
sepsis,
atherosclerosis,
cancer,
autoimmune
disorders,
hypersensitivity.
It
orchestrates
related
responses,
inflammation,
survival,
proliferation.
Consequently,
its
malfunction
key
contributor
onset
development
these
diseases.
This
review
aims
summarize
function
regulating
activity
particular
emphasis
on
their
relevance
human
diseases
potential
therapeutic
targets.
The
insights
gained
studies
lncRNAs,
discussed
this
review,
could
provide
valuable
knowledge
treatments
involving
Frontiers in Immunology,
Год журнала:
2021,
Номер
12
Опубликована: Дек. 9, 2021
Sepsis
is
resulted
from
a
systemic
inflammatory
response
to
bacterial,
viral,
or
fungal
agents.
The
induced
by
these
microorganisms
can
lead
multiple
organ
system
failure
with
devastating
consequences.
Recent
studies
have
shown
altered
expressions
of
several
non-coding
RNAs
such
as
long
(lncRNAs),
microRNAs
(miRNAs)
and
circular
(circRNAs)
during
sepsis.
These
transcripts
also
been
found
participate
in
the
pathogenesis
through
different
mechanisms.
NEAT1,
MALAT1,
THRIL,
XIST,
MIAT
TUG1
are
among
lncRNAs
that
pathoetiology
sepsis-related
complications.
miR-21,
miR-155,
miR-15a-5p,
miR-494-3p,
miR-218,
miR-122,
miR-208a-5p,
miR-328
miR-218
examples
miRNAs
participating
Finally,
tens
circRNAs
circC3P1,
hsa_circRNA_104484,
hsa_circRNA_104670
circVMA21
circ-PRKCI
affect
In
current
review,
we
describe
role
three
classes
noncoding
Frontiers in Immunology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 4, 2023
Macrophages
(Mφ)
are
long-lived
myeloid
cells
that
can
polarize
towards
the
proinflammatory
M1
or
proresolving
M2
phenotype
to
control
diverse
biological
processes
such
as
inflammation,
tissue
damage,
and
regeneration.
Noncoding
RNA
a
class
of
nonprotein-coding
transcriptome
with
numerous
interdependent
roles;
however,
their
functional
interaction
in
regulation
Mφ
polarization
immune
responses
remain
unclear.
Here,
we
show
antagonistic
relationship
between
lncRNA
(MALAT1)
microRNA
(miR-30b)
shaping
macrophage
functions.
MALAT1
expression
displays
time-dependent
induction
during
differentiation
and,
upon
challenge
TLR4
agonist
(E.
coli
LPS).
knockdown
promoted
M2Mφ
markers
without
affecting
M1Mφ
markers,
suggesting
favors
by
suppressing
differentiation.
Compared
control,
resulted
reduced
antigen
uptake
processing,
bacterial
phagocytosis,
bactericidal
activity,
strongly
supporting
its
critical
role
regulating
innate
functions
Mφ.
Consistent
this,
showed
impaired
cytokine
secretion
LPS.
Importantly,
exhibit
an
pattern
all
five
members
miR-30
family
Dual-luciferase
assays
validated
novel
sequence
on
interacts
miR-30b,
promotes
phenotype.
Phagocytosis
processing
unequivocally
demonstrated
miR-30b
functionally
antagonistic.
Concurrent
overexpression
exhibited
most
significant
attenuation
both
assays.
In
human
subjects
periodontal
disease
murine
model
ligature-induced
periodontitis,
observed
higher
levels
MALAT1,
downregulation
gingival
tissues
pro-inflammatory
function
vivo
.
Overall,
unraveled
delineated
underlying
mechanism
involving
MALAT-1-driven
sequestration.
International Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown, С. 1 - 15
Опубликована: Янв. 31, 2024
Intracerebral
hemorrhage
(ICH)
has
significant
morbidity
and
mortality.
TXNIP
the
competing
endogenous
RNA
(ceRNA)
regulatory
mechanism
involved
in
long
non-coding
(lncRNA)
play
roles
ICH.
We
probed
upstream
microRNAs
(miRNAs)/lncRNAs
that
regulated
expression
ceRNA
mechanism.
The
studies
regarding
macrophage
lncRNAs
described
in
this
review
can
help
provide
valuable
information
for
developing
treatments
various
pathological
conditions
involving
macrophages.
Over
the
past
century,
molecular
biology's
focus
has
transitioned
from
proteins
to
DNA,
and
now
RNA.
Once
considered
merely
a
genetic
carrier,
RNA
is
recognized
as
both
vital
element
early
cellular
life
regulator
complex
organisms.
Long
noncoding
RNAs
(lncRNAs),
which
are
over
200
bases
long
but
do
not
code
proteins,
play
roles
gene
expression
regulation
signal
transduction
by
inducing
epigenetic
changes
or
interacting
with
RNAs.
These
interactions
exhibit
range
of
functions
cell
types
including
Notably,
some
influence
activation
NF-κB,
crucial
transcription
factor
governing
immune
inflammatory
responses.
Macrophage
NF-κB
instrumental
progression
sepsis,
atherosclerosis,
cancer,
autoimmune
disorders,
hypersensitivity.
It
orchestrates
related
responses,
inflammation,
survival,
proliferation.
Consequently,
its
malfunction
key
contributor
onset
development
these
diseases.
This
summarizes
role
that
regulate
especially
focusing
on
their
implications
human
diseases
potential
therapeutic
targets
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 18, 2025
Sepsis,
a
life-threatening
condition
arising
from
an
uncontrolled
immune
response
to
infection,
can
lead
organ
dysfunction,
with
severe
inflammation
potentially
causing
multiple
failures.
Sepsis-induced
cardiac
dysfunction
(SIMD)
is
common
and
complication
of
sepsis,
significantly
increasing
patient
mortality.
Understanding
the
pathogenesis
SIMD
crucial
for
improving
treatment,
microRNAs
(miRNAs)
have
emerged
as
important
regulators
in
this
process.
A
comprehensive
literature
search
was
conducted
PubMed,
Science
Direct,
Embase
databases
up
September
2024.
The
terms
included
["miRNA"
or
"microRNA"]
["Cardiac"
"Heart"]
["Sepsis"
"Septic"],
language
limited
English.
After
initial
filtering
by
database
engine,
Excel
software
used
further
screen
references.
Duplicate
articles,
those
without
abstracts
full
texts,
review/meta-analyses
non-English
articles
were
excluded.
Finally,
106
relevant
research
data
extraction
analysis.
complex
involves
mitochondrial
oxidative
stress,
cardiomyocyte
apoptosis
pyroptosis,
dysregulation
myocardial
calcium
homeostasis,
inhibitory
factors,
autonomic
nervous
regulation
disorders,
hemodynamic
changes,
structural
alterations.
miRNAs
play
diverse
roles
SIMD.
They
are
involved
regulating
above-mentioned
pathological
processes.
Although
significant
progress
has
been
made
understanding
role
SIMD,
there
still
challenges.
Some
studies
on
limitations
such
small
sample
sizes
failure
account
confounding
factors.
Research
also
faces
issues
like
inconsistent
measurement
techniques
unclear
miRNA-target
gene
relationships.
Moreover,
translation
miRNA-based
into
clinical
applications
hindered
problems
related
miRNA
stability,
delivery
mechanisms,
off-target
effects,
long-term
safety.
In
conclusion,
potential
diagnostic
biomarkers.
Further
needed
overcome
existing
challenges
fully
exploit
diagnosis
treatment
