Inflammaging Markers in the Extremely Cold Climate: A Case Study of Yakutian Population DOI Open Access
Alena Kalyakulina, Igor Yusipov, Elena Kondakova

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(24), С. 13741 - 13741

Опубликована: Дек. 23, 2024

Yakutia is one of the coldest permanently inhabited regions in world, characterized by a subarctic climate with average January temperatures near −40 °C and minimum below −60 °C. Recently, we demonstrated accelerated epigenetic aging Yakutian population comparison to their Central Russian counterparts, residing considerably milder climate. In this paper, analyzed these cohorts from inflammaging perspective addressed two hypotheses: mismatch immunological profiles inflammatory Yakuts. We found that levels 17 cytokines displayed statistically significant differences mean values between groups (with minimal p-value = 2.06 × 10−19), 6 them are among 10 SImAge markers. five out six markers (PDGFB, CD40LG, VEGFA, PDGFA, CXCL10) had higher cohort, therefore, due positive chronological age correlation, might indicate trend toward aging. At same time, biological acceleration difference according clock was not detected because they similar CXCL9, CCL22, IL6, top contributing biomarkers SImAge. introduced an explainable deep neural network separate individual groups, resulting over 95% accuracy. The obtained results allow for hypothesizing specificity cytokine chemokine people living extremely cold climates, possibly reflecting effects long-term human (dis)adaptation conditions related risk developing number pathologies.

Язык: Английский

The connection between 91 inflammatory cytokines and frailty mediated by 1400 metabolites: An exploratory two-step Mendelian randomization analysis DOI Creative Commons
Bo Wen, Shi‐Zhuang Wei,

Daolai Huang

и другие.

Archives of Gerontology and Geriatrics, Год журнала: 2025, Номер 133, С. 105774 - 105774

Опубликована: Фев. 25, 2025

Язык: Английский

Процитировано

0
Risk factors and predictive modeling in a US population with sarcopenia: a propensity score cohort study DOI Creative Commons

Yao Sun,

Shuguang Yang,

Zengli Xiao

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 26, 2025

Sarcopenia, characterized by loss of muscle mass and strength, particularly affects older adults is linked to increased morbidity mortality. The study aimed investigate the relationship between biomarkers, including hemoglobin (Hb), lactate dehydrogenase (LDH), Systemic Immune-Inflammation Index (SII), sarcopenia in US population. Utilizing NHANES data from 2003 2018, analyzed 5,615 participants, categorizing them based on quartiles Hb, SII, LDH levels. It employed logistic regression models assess these biomarkers risk, adjusting for various confounders. High levels LDH, Hb SII were significantly associated with sarcopenia, higher risk highest quartile. AUC all indicators predicting was 0.925 (sensitivity 0.925; specificity 0.743). concludes that elevated are significant emphasizing role inflammation its development potential markers early detection intervention.

Язык: Английский

Процитировано

0
Peripheral and central inflammation in depression: How large is the gap and can we bridge it with PET neuroimaging and neural-derived extracellular vesicles? DOI
Cristian-Daniel Llach, Gia Han Le,

Hiya Shah

и другие.

Journal of Neuroimmunology, Год журнала: 2025, Номер unknown, С. 578587 - 578587

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Inflammatory biomarkers and childhood maltreatment: a cluster analysis in patients with eating disorders DOI Creative Commons
Cristiano Dani, Livio Tarchi, E. Rossi

и другие.

Psychoneuroendocrinology, Год журнала: 2025, Номер 174, С. 107405 - 107405

Опубликована: Фев. 14, 2025

Язык: Английский

Процитировано

0
Unveiling a novel in-vitro model of skin inflammaging DOI Creative Commons
Ying Xu, Yue Liu,

Jun‐Xiang Li

и другие.

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Март 28, 2025

Sensitive skin is characterized by a disrupted barrier, making it prone to reacting external stimuli, including UV exposure, air pollution, and cosmetic allergens. tends react with oxidative stress factors that could further lead inflammation subsequently result in inflammaging. However, there are almost no existing inflammaging models specifically for sensitive skin, highlighting the need develop method screening anti-inflammaging ingredients products. An vitro macrophage-fibroblast model was established evaluate effects of ingredients. The M1 phenotype aging-associated gene expression were assessed using qPCR validate model. RNA sequencing used elucidate mechanisms two validated A novel in-vitro developed applying supernatant macrophage culture medium induce cellular senescence fibroblast cells, facilitating In this model, supramolecular bakuchiol promote collagen COL1A1 COL3A3 production inhibit inflammatory enhancing transcription anti-inflammatory genes (PTX3, ADAM33, PDLIM1), while Terminalia chebula extract inhibits cell reducing MAP4K2 accumulation factor CCL3.

Язык: Английский

Процитировано

0
Immune Dysregulation in Depression and Anxiety: A Review of the Immune Response in Disease and Treatment DOI Creative Commons

Christopher Hole,

Akash Dhamsania,

Cassandra Brown

и другие.

Cells, Год журнала: 2025, Номер 14(8), С. 607 - 607

Опубликована: Апрель 17, 2025

Rates of depression and anxiety have increased significantly in recent decades, with many patients experiencing treatment-resistant symptoms. Beyond psychiatric manifestations, these conditions are associated heightened risks suicide, cardiovascular disease, chronic pain, fatigue. Emerging research suggests that neuroinflammation, immune dysregulation, hypothalamic–pituitary–adrenal axis dysfunction contribute to their pathophysiology, often interacting bidirectionally stress. While current first-line treatments primarily target neurotransmitter imbalances, do not achieve symptom resolution, highlighting the need for novel approaches. This review explores role dysfunction, cytokine activity, interactions anxiety. Additionally, we examine how existing pharmacological non-pharmacological interventions influence inflammation responses. Understanding mechanisms may pave way more integrative treatment strategies combine modulation traditional therapies.

Язык: Английский

Процитировано

0
The composition of single-donor apheresis platelet concentrates is influenced by the age of the donor DOI Creative Commons
Anne‐Claire Duchez,

Charles‐Antoine Arthaud,

Marie‐Ange Eyraud

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 18, 2025

Abstract The aging population often faces health issues that sometimes necessitate transfusions. Transfusion services are increasingly concerned about the rising number of transfusions and donor population, as both factors crucial in maintaining quality blood donations. In this context, our study aims to measure bioactive molecule cytokine levels single apheresis platelet concentrates (SDA-PC) based on donor’s age determine whether these cytokines, conjunction with age, could contribute transfusion adverse reactions (AR). Our findings indicate well-known molecules such sCD62P, well IL-13, ADAMTS13, MIP-1α, NGAL, MCP-3, HSAA, GDF-15, CX3CL1, MDC, were present SDA-PC. Levels sCD62P increased aging, whereas MDC decreased. conclusion, most detected elevated cases AR increasing age. Notably, GDF-15 was only showed a positive correlation context AR.

Язык: Английский

Процитировано

0
Role of chemokines in aging and age-related diseases DOI
Jitendra Kumar Chaudhary, Ajay Kumar Danga, A. Leela Kumari

и другие.

Mechanisms of Ageing and Development, Год журнала: 2024, Номер unknown, С. 112009 - 112009

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

2
Erythroderma in the elderly DOI Creative Commons
Toshiyuki Yamamoto

The Journal of Dermatology, Год журнала: 2024, Номер 52(2), С. 221 - 227

Опубликована: Ноя. 11, 2024

Erythroderma is the end-stage condition caused by various inflammatory diseases, presenting with widespread generalized coalesced erythema on trunk and extremities. not a disease itself, but rather symptom expressing erythrodermic condition, which frequently associated inguinal lymphadenopathy, chills, mild fever. The clinical characteristics include sparing folds of extremities (deck-chair sign), cobblestone-like disseminated grouping prurigo; however, deck-chair sign specific to papulo-erythroderma (Ofuji disease). induced causes, such as eczema, psoriasis, atopic dermatitis, drug eruption, lymphoma, lichen planus, pityriasis rubra pilaris, autoimmune bullous graft-versus-host disease, dermatomyositis, internal malignancy, others. By contrast, it uncommon for even thorough investigations often fail identify any significant underlying or occult diseases. Such cases are diagnosed idiopathic erythroderma. In elderly cases, some regard erythroderma late-onset if patient does have history childhood while others consider distinct immune responses similar dermatitis. etiology suggested be Th2-dominant IL-4/IL-13 playing central role, suggesting that therapies targeting those Th2 molecules may result in sufficient effects. this review, new therapeutic approaches discussed.

Язык: Английский

Процитировано

1
A retrospective cohort study on the association between nutritional status and prognosis in COVID-19 patients with severe and critical infection DOI Creative Commons
S. Je ́gou, Dan Tang, Weiyi Li

и другие.

Journal of International Medical Research, Год журнала: 2024, Номер 52(11)

Опубликована: Ноя. 1, 2024

Objective To evaluate the relationship between nutritional scoring systems, support methods, and prognosis of severe critically ill patients infected with Omicron variant coronavirus disease 2019 (COVID-19). Methods Patients confirmed critical COVID-19, who were admitted to Chongqing Medical University First Hospital December 2022 January 2023, enrolled into this retrospective study. Clinical data survived for 28 days compared those died during same period. Nutritional status was assessed using 2002 Nutrition Risk Screening (NRS) tool Prognostic Index (PNI). Factors influencing patient mortality identified by multivariate logistic regression, nutrition as progressed illustrated Kaplan–Meier curves. The study registered on ChiCTR platform (No. ChiCTR2300067595). Results A total 508 included (349 survivors 159 non-survivors). Significant differences found in sex, age, NRS score, PNI albumin level, lymphocyte count, chronic comorbidities, mechanical ventilation, neutrophil procalcitonin, platelet count non-survivors. Multivariate analysis revealed that high score (OR 3.87, 95% CI, 1.97, 7.63), fourth-level (combined enteral parenteral nutrition; OR 7.89, 1.32, 47.28), comorbidities 4.03, 1.91, 8.51), ventilation 6.03, 3, 12.13) risk factors > 1). malnutrition rate among ≥ 3 41.93%. median (interquartile range) 38.20 (35.65, 41.25) versus 32.65 (29.65, 36.58) higher within hospitalization. descending order receiving different was: dual nutrition, no intervention, single nutrition. Conclusion proportion COVID-19 experience malnutrition, various are associated their prognosis. High is significantly related mortality. Early assessment or crucial these patients, personalized interventions should be implemented improve overall status, maintain organ function, enhance body’s antiviral defence.

Язык: Английский

Процитировано

0