G3 Genes Genomes Genetics,
Год журнала:
2021,
Номер
11(3)
Опубликована: Март 1, 2021
In
Drosophila
raised
in
nutrient-rich
conditions,
female
body
size
is
approximately
30%
larger
than
male
due
to
an
increased
rate
of
growth
and
differential
weight
loss
during
the
larval
period.
While
mechanisms
that
control
this
sex
difference
remain
incompletely
understood,
recent
studies
suggest
insulin/insulin-like
factor
signaling
pathway
(IIS)
plays
a
role
sex-specific
regulation
processes
influence
development.
larvae,
IIS
activity
differs
between
sexes,
there
evidence
ligands.
Yet,
we
lack
knowledge
how
changes
impact
each
sex,
as
majority
on
use
single-
or
mixed-sex
groups
larvae
and/or
adult
flies.
The
goal
our
current
study
was
clarify
requirement
for
sex.
To
achieve
goal,
used
established
genetic
approaches
enhance,
inhibit,
activity,
quantified
pupal
males
females.
Overall,
genotypes
inhibited
caused
female-biased
decrease
size,
whereas
augmented
male-specific
increase
size.
These
data
extend
understanding
by
showing
most
have
sex-biased
effects,
highlights
importance
analyzing
according
Current Opinion in Cell Biology,
Год журнала:
2024,
Номер
87, С. 102323 - 102323
Опубликована: Фев. 1, 2024
The
process
of
embryonic
development
involves
remarkable
cellular
plasticity,
which
governs
the
coordination
between
cells
necessary
to
build
an
organism.
One
role
this
plasticity
is
ensure
that
when
aberrant
are
eliminated,
growth
adjustment
occurs
so
size
tissue
maintained.
An
important
regulator
ensures
cooperation
a
fitness-sensing
mechanism
termed
cell
competition.
During
competition,
with
defects
lower
fitness
but
do
not
affect
viability,
such
as
those
cause
impaired
signal
transduction,
slower
growth,
mitochondrial
dysregulation
or
protein
homeostasis,
killed
surrounded
by
fitter
cells.
This
accompanied
compensatory
proliferation
surviving
underlying
factors
and
mechanisms
demarcate
certain
less
fit
than
their
neighbouring
losers
competition
still
relatively
unknown.
Recent
evidence
has
pointed
proteotoxic
stress
hallmarks
these
loser
Here,
we
review
recent
advances
in
area,
focussing
on
activity
homeostasis
major
determining
competitive
during
importance
proteostasis
fitness.
Drosophila
melanogaster
is
a
highly
versatile
model
organism
that
has
profoundly
advanced
our
understanding
of
human
diseases.
With
more
than
60%
its
genes
having
homologs,
provides
an
invaluable
system
for
modelling
wide
range
pathologies,
including
neurodegenerative
disorders,
cancer,
metabolic
diseases,
as
well
cardiac
and
muscular
conditions.
This
review
highlights
key
developments
in
utilizing
disease
modelling,
emphasizing
the
genetic
tools
have
transformed
research
this
field.
Technologies
such
GAL4/UAS
system,
RNA
interference
(RNAi)
CRISPR-Cas9
enabled
precise
manipulation,
with
allowing
introduction
mutations
into
orthologous
genes.
These
approaches
yielded
critical
insights
mechanisms,
identified
novel
therapeutic
targets
facilitated
both
drug
screening
toxicological
studies.
Articles
were
selected
based
on
their
relevance,
impact
contribution
to
field,
particular
focus
studies
offering
innovative
perspectives
mechanisms
or
strategies.
Our
findings
emphasize
central
role
studying
complex
underscoring
similarities
humans
effectiveness
conditions
Alzheimer's
disease,
Parkinson's
cancer.
reaffirms
Drosophila's
organism,
highlighting
potential
drive
future
advancements.
Cancer Discovery,
Год журнала:
2022,
Номер
13(1), С. 85 - 97
Опубликована: Сен. 13, 2022
Abstract
Cell
competition,
a
fitness-sensing
process,
is
essential
for
tissue
homeostasis.
Using
cancer
metastatic
latency
models,
we
show
that
cell
competition
results
in
the
displacement
of
latent
(Lat-M)
cells
from
primary
tumor.
Lat-M
resist
anoikis
and
survive
as
residual
disease.
A
memodeled
extracellular
matrix
facilitates
survival
circulation.
Disrupting
dynamics
by
depleting
secreted
protein
rich
cysteine
(SPARC)
reduced
orthotopic
tumors
attenuated
metastases.
In
contrast,
depletion
SPARC
after
extravasation
lung-resident
increased
outgrowth.
Furthermore,
multiregional
transcriptomic
analyses
matched
metachronous
metastases
patients
with
kidney
identified
tumor
subclones
traits.
Kidney
enriched
these
traits
had
rapid
onset
significantly
disease-free
survival.
Thus,
an
unexpected
consequence
potential,
thereby
shaping
relapse.
Significance:
We
demonstrate
within
cells.
further
impact
altering
on
incidence
may
guide
strategies
to
limit
recurrences.
This
article
highlighted
Issue
feature,
p.
1
G3 Genes Genomes Genetics,
Год журнала:
2021,
Номер
11(3)
Опубликована: Март 1, 2021
In
Drosophila
raised
in
nutrient-rich
conditions,
female
body
size
is
approximately
30%
larger
than
male
due
to
an
increased
rate
of
growth
and
differential
weight
loss
during
the
larval
period.
While
mechanisms
that
control
this
sex
difference
remain
incompletely
understood,
recent
studies
suggest
insulin/insulin-like
factor
signaling
pathway
(IIS)
plays
a
role
sex-specific
regulation
processes
influence
development.
larvae,
IIS
activity
differs
between
sexes,
there
evidence
ligands.
Yet,
we
lack
knowledge
how
changes
impact
each
sex,
as
majority
on
use
single-
or
mixed-sex
groups
larvae
and/or
adult
flies.
The
goal
our
current
study
was
clarify
requirement
for
sex.
To
achieve
goal,
used
established
genetic
approaches
enhance,
inhibit,
activity,
quantified
pupal
males
females.
Overall,
genotypes
inhibited
caused
female-biased
decrease
size,
whereas
augmented
male-specific
increase
size.
These
data
extend
understanding
by
showing
most
have
sex-biased
effects,
highlights
importance
analyzing
according
