Abstract
Cuproptosis,
the
current
form
of
regulated
cell
death
characterized
by
copper
overload,
oligomerization
lipoacylated
proteins,
and
loss
Fe–S
cluster
has
been
proposed
to
function
closely
with
human
diseases,
including
cancer.
Since
its
first
identification
in
2022,
many
strategies
have
developed
induce
cuproptosis
for
cancer
therapy,
such
as
small‐molecule
drugs
nanomaterials.
Although
reviews
related
reported,
they
remain
at
a
basic
mechanism
level,
summary
covering
recent
progress
field
nanotechnologies
cuproptosis‐based
therapy
not
yet
presented.
Therefore,
it
is
time
fill
gap
shed
light
on
future
directions
application
this
promising
tool
fight
against
In
minireview,
we
expounded
action
emphasized
feasibility
triggering
therapy.
The
treatments
based
nanoparticle‐induced
was
then
described.
Finally,
challenges
development
emerging
are
also
discussed.
Cancer Communications,
Год журнала:
2022,
Номер
42(12), С. 1234 - 1256
Опубликована: Сен. 15, 2022
Abstract
Pancreatic
cancer
is
one
of
the
most
serious
health
issues
in
developed
and
developing
countries,
with
a
5‐year
overall
survival
rate
currently
<9%.
Patients
typically
present
advanced
disease
due
to
vague
symptoms
or
lack
screening
for
early
detection.
Surgical
resection
represents
only
chance
cure,
but
treatment
options
are
limited
diseases,
such
as
distant
metastatic
locally
progressive
tumors.
Although
adjuvant
chemotherapy
has
improved
long‐term
outcomes
patients,
its
response
low.
So,
exploring
other
new
treatments
urgent.
In
recent
years,
increasing
evidence
shown
that
lipid
metabolism
can
support
tumorigenesis
progression
well
resistance
through
enhanced
synthesis,
storage,
catabolism.
Therefore,
better
understanding
networks
may
provide
novel
promising
strategies
diagnosis,
prognosis
estimation,
targeted
therapy
pancreatic
patients.
this
review,
we
first
enumerate
discuss
current
knowledge
about
advances
made
regulation
cancer.
addition,
summarize
preclinical
studies
clinical
trials
drugs
targeting
metabolic
systems
Finally,
highlight
challenges
opportunities
pathways
precision
therapies
Biomedicines,
Год журнала:
2022,
Номер
10(8), С. 1943 - 1943
Опубликована: Авг. 11, 2022
Glioblastoma
(GBM)
is
the
most
lethal
primary
brain
tumor.
With
limited
therapeutic
options,
novel
therapies
are
desperately
needed.
Recent
studies
have
shown
that
GBM
acquires
large
amounts
of
lipids
for
rapid
growth
through
activation
sterol
regulatory
element-binding
protein
1
(SREBP-1),
a
master
transcription
factor
regulates
fatty
acid
and
cholesterol
synthesis,
uptake.
Interestingly,
cells
divert
substantial
quantities
into
lipid
droplets
(LDs),
specific
storage
organelle
neutral
lipids,
to
prevent
lipotoxicity
by
increasing
expression
diacylglycerol
acyltransferase
(DGAT1)
sterol-O-acyltransferase
(SOAT1),
which
convert
excess
acids
triacylglycerol
cholesteryl
esters,
respectively.
In
this
review,
we
will
summarize
recent
progress
on
our
understanding
metabolism
regulation
in
promote
tumor
discuss
strategies
specifically
induce
disrupting
storage,
promising
new
avenue
treating
GBM.
Frontiers in Oncology,
Год журнала:
2022,
Номер
12
Опубликована: Июнь 15, 2022
Gastric
cancer
has
been
one
of
the
most
common
cancers
worldwide
with
extensive
metastasis
and
high
mortality.
Chemotherapy
found
as
a
main
treatment
for
metastatic
gastric
cancer,
whereas
drug
resistance
limits
effectiveness
chemotherapy
leads
to
failure.
in
complex
multifactorial
mechanism,
among
which
lipid
metabolism
plays
vital
role.
Increased
synthesis
new
lipids
or
uptake
exogenous
can
facilitate
rapid
growth
cells
tumor
formation.
Lipids
form
structural
basis
biofilms
while
serving
signal
molecules
energy
sources.
It
is
noteworthy
that
capable
inducing
by
reshaping
micro-environment.
In
this
study,
mechanisms
metabolic
pathways
correlated
are
reviewed.
particular,
we
discuss
effects
on
autophagy,
biomarkers
from
perspective
metabolism.
brief,
insights
be
gained
into
development
promising
therapies
through
an
in-depth
investigation
mechanism
reprogramming
resensitization
cells,
scientific
provided
applying
lipid-key
enzyme
inhibitors
chemical
sensitizers
clinical
settings.
Abstract
Cuproptosis,
the
current
form
of
regulated
cell
death
characterized
by
copper
overload,
oligomerization
lipoacylated
proteins,
and
loss
Fe–S
cluster
has
been
proposed
to
function
closely
with
human
diseases,
including
cancer.
Since
its
first
identification
in
2022,
many
strategies
have
developed
induce
cuproptosis
for
cancer
therapy,
such
as
small‐molecule
drugs
nanomaterials.
Although
reviews
related
reported,
they
remain
at
a
basic
mechanism
level,
summary
covering
recent
progress
field
nanotechnologies
cuproptosis‐based
therapy
not
yet
presented.
Therefore,
it
is
time
fill
gap
shed
light
on
future
directions
application
this
promising
tool
fight
against
In
minireview,
we
expounded
action
emphasized
feasibility
triggering
therapy.
The
treatments
based
nanoparticle‐induced
was
then
described.
Finally,
challenges
development
emerging
are
also
discussed.
