Kinase Inhibitors in the Treatment of Ovarian Cancer: Current State and Future Promises

Cancers, Год журнала: 2022, Номер 14(24), С. 6257 - 6257

Опубликована: Дек. 19, 2022

Ovarian cancer is the deadliest gynecological cancer, high-grade serous ovarian carcinoma (HGSC) being its most common and aggressive form. Despite latest therapeutical advancements following introduction of vascular endothelial growth factor receptor (VEGFR) targeting angiogenesis inhibitors poly-ADP-ribose-polymerase (PARP) to supplement standard platinum- taxane-based chemotherapy, expected overall survival HGSC patients has not improved significantly from five-year rate 42%. This calls for development testing more efficient treatment options. Many oncogenic kinase-signaling pathways are dysregulated in HGSC. Since small-molecule kinase have revolutionized many solid cancers due generality increased activation protein kinases carcinomas, it reasonable evaluate their potential against Here, we present concluded on-going clinical trials on HGSC, as well recent work concerning patient organoids xenograft models. We discuss personalized treatments, which would require comprehensive assessment biological mechanisms underlying tumor spread chemoresistance individual patients, connection genome transcriptome establish identifiable subgroups who likely benefit a given therapy.

Язык: Английский

---

Emerging roles of 3D-culture systems in tackling tumor drug resistance

Cancer Drug Resistance, Год журнала: 2023, Номер 6(4), С. 788 - 804

Опубликована: Ноя. 21, 2023

Drug resistance that affects patients universally is a major challenge in cancer therapy. The development of drug cells multifactor event, and its process involves numerous mechanisms allow these to evade the effect treatments. As result, need understand molecular underlying sensitivity imperative. Traditional 2D cell culture systems have been utilized study resistance, but they often fail mimic 3D milieu architecture real tissues cell-cell interactions. result this, are now considered comprehensive model vitro . Cancer exhibit an vivo behavior when grown three-dimensional environment react therapy more physiologically. In this review, we discuss relevance main potential approaches overcome identification personalized targets with aim developing patient-specific treatment strategies can be put place emerges.

Язык: Английский

---

Can Nitric Oxide-Based Therapy Be Improved for the Treatment of Cancers? A Perspective

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(17), С. 13611 - 13611

Опубликована: Сен. 2, 2023

Since the early observations that nitric oxide (•NO) at high concentrations is cytotoxic to cancer cells and it may play an important role in treatment of human cancers, a significant number compounds (NO-donors) have been prepared deliver •NO tumors. also sensitizes various clinically active anticancer drugs has shown induce reversal multi-drug resistance tumor expressing ATP-binding cassette-transporter proteins. For successful needs be delivered precisely tumors, its adverse toxicity must limited. Like other chemotherapeutics, precise delivery problem attempts made, such as encapsulation lipid polymers, overcome this. This prospective study examines use strategies for delivering (using NO-donors) cancers. Finding utilizing system step tumors without reactions, leading clinical outcome patient management.

Язык: Английский

---

Patient‐derived organoid culture in epithelial ovarian cancers—Techniques, applications, and future perspectives

Cancer Medicine, Год журнала: 2023, Номер 12(19), С. 19714 - 19731

Опубликована: Сен. 30, 2023

Epithelial ovarian cancer (EOC) is a heterogeneous disease composed of different cell types with molecular aberrations. Traditional lines and mice models cannot recapitulate the human tumor biology microenvironment (TME). Patient-derived organoids (PDOs) are freshly derived from patients' tissues then cultured extracellular matrix conditioned medium. The high concordance epigenetic, genomic, proteomic landscapes between parental tumors PDOs suggests that can provide more reliable results in studying biology, allowing throughput drug screening, identifying their associated signaling pathways resistance mechanisms. However, despite having heterogeneity cells PDOs, some TME will be lost during culture process. Next-generation have been developed to circumvent limitations. Genetically engineered involving targeted gene editing facilitate understanding tumorigenesis response. Co-culture systems where components like immune allow research using immunotherapy which otherwise impossible conventional lines. In this review, limitations traditional vitro vivo assays, use challenges including tips tricks PDO generation EOC, future perspectives, discussed.

Язык: Английский

---

Lung cancer organoids: models for preclinical research and precision medicine

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Окт. 24, 2023

Lung cancer is a malignancy with high incidence and mortality rates globally, it has 5-year survival rate of only 10%–20%. The significant heterogeneity in clinical presentation, histological features, multi-omics findings, drug sensitivity among different lung patients necessitate the development personalized treatment strategies. current precision medicine for cancer, primarily based on pathological genomic testing, fails to meet needs clinically refractory cancer. organoids (LCOs) are derived from tumor cells within tissues generated through three-dimensional tissue culture, enabling them faithfully recapitulate vivo characteristics heterogeneity. establishment series LCOs biobanks offers promising platforms efficient screening identification novel targets anti-tumor discovery. Moreover, provide supplementary decision-making factors enhance thereby addressing limitations associated pathology-guided approaches managing This article presents comprehensive review construction methods potential applications both preclinical research. It highlights significance biomarker exploration, resistance investigation, target identification, screening, as well microfluidic technology-based high-throughput Additionally, discusses future prospects this field.

Язык: Английский

---