Interplay of CD36, autophagy, and lipid metabolism: insights into cancer progression
Metabolism,
Год журнала:
2024,
Номер
155, С. 155905 - 155905
Опубликована: Март 26, 2024
Язык: Английский
SNARE proteins: Core engines of membrane fusion in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer,
Год журнала:
2024,
Номер
unknown, С. 189148 - 189148
Опубликована: Июль 1, 2024
Язык: Английский
Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity
Cell Reports,
Год журнала:
2024,
Номер
43(9), С. 114762 - 114762
Опубликована: Сен. 1, 2024
Язык: Английский
Protocatechuic Acid Reduces Liver Fatty Acid Uptake in HFD‐Fed Mice Associated With the Inhibition of DHHC5‐Mediated CD36 Palmitoylation
Molecular Nutrition & Food Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 20, 2025
ABSTRACT
Metabolic
dysfunction‐associated
steatotic
liver
disease
(MASLD)
is
highly
prevalent
and
has
emerged
as
a
pressing
issue
for
human
health.
A
palmitoylated
cluster
of
differentiation
36
(CD36)
promotes
free
fatty
acid
(FFA)
uptake,
which
contributes
to
the
development
MASLD.
Protocatechuic
(PCA),
main
metabolite
anthocyanins,
was
reported
inhibit
MASLD
by
regulating
expression
CD36.
However,
impact
PCA
on
CD36
palmitoylation
not
been
extensively
studied.
In
present
study,
we
found
that
could
significantly
reduce
lipid
uptake
accumulation
in
hepatocytes
decreasing
palmitoylation.
Inhibitors
were
used
prove
suppressed
lowering
zinc
finger
DHHC‐type
palmitoyltransferase
5
(DHHC5)
palmitoylation,
but
an
acyl
protein
thioesterase
1
(APT1)‐dependent
manner.
Further
experiments
showed
PCA‐mediated
inhibition
DHHC5
acyltransferase
activity
closely
related
reduction
CD36/Fyn/Lyn
complex.
diminished
ultimately
lessened
hepatocytes.
Язык: Английский
Black tea extracts enhance stress-induced sleep of Caenorhabditis elegans to resist UV damage
Food Research International,
Год журнала:
2024,
Номер
196, С. 115025 - 115025
Опубликована: Сен. 6, 2024
Язык: Английский
Involvement of the AMPK Pathways in Muscle Development Disparities across Genders in Muscovy Ducks
Wanxin Zhao,
Yulin He,
Ziyuan Du
и другие.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10132 - 10132
Опубликована: Сен. 21, 2024
The
differences
in
muscle
development
potential
between
male
and
female
ducks
lead
to
variations
body
weight,
significantly
affecting
the
growth
of
Muscovy
duck
meat
industry.
aim
this
study
is
explore
regulatory
mechanisms
for
genders.
both
sexes
were
selected
measurements
traits,
hormone
levels,
gene
expression.
results
show
that
compared
females
had
greater
weight
traits
(p
<
0.05).
Compared
ducks,
level
serum
testosterone
was
decreased,
estradiol
levels
increased
RNA-seq
analysis
identified
102
upregulated
49
downregulated
differentially
expressed
genes.
KEGG
revealed
among
top
10
enriched
pathways,
AMPK
signaling
pathway
closely
related
development.
Additionally,
mRNA
protein
CD36,
CPT1A,
LPL,
SREBP1
P-AMPK
decreased
In
conclusion,
difference
regulated
by
sex
hormones.
This
process
likely
mediated
through
activation
pathway.
Язык: Английский
Context-specific fatty acid uptake is a finely-tuned multi-level effort
Trends in Endocrinology and Metabolism,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Transcriptome analysis reveals the regulatory mechanism of myofiber development in male and female black Muscovy duck at different ages
Weihong Zhang,
Mengyun Zou,
Xiaolan Xiong
и другие.
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 20, 2024
Sexual
dimorphism
in
Muscovy
ducks
results
substantial
differences
muscle
development
potential
between
males
and
females,
leading
to
significant
variations
growth
rates
body
weights
throughout
their
development.
Язык: Английский
Long-Term Propolis Intake-Induced Liver Lipid Remodeling in Mice: Effects on Phospholipid-to-Glycerolipid Metabolism and Free Fatty Acid-Mediated Thermogenesis
Tao Liu,
Zhuozhen Li,
Quanyuan Xie
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Research
on
the
patterns
and
mechanisms
of
liver
lipid
remodeling
regulated
by
propolis
is
limited.
In
present
study,
nine-month
experimental
duration
has
shed
light
positive
influences
metabolism
thermogenesis
capacity
in
livers
mice.
Eight
major
compounds
were
characterized
using
UPLC-QTOF-MS
technology.
Propolis
significantly
lowered
serum
triglycerides
(TGs)
low-density
lipoprotein
cholesterol
(LDL-C),
but
it
also
led
to
increased
insulin
(INS)
levels.
Lipidomics
change
trend
analysis
1671
components
across
42
categories
revealed
that
level
glycerophospholipids
(GPs)
decreased
while
glycerolipids
(GLs)
fatty
acids
(FAs)
liver.
The
expression
levels
eight
key
genes
involved
conversion
GP
GL
pathways
enhanced
group.
Molecular
docking
results
elucidated
high
binding
affinities
between
receptors
metabolism,
indicating
primary
possess
potent
capabilities
for
phospholipid
lipolysis.
These
imply
could
facilitate
browning
adipose
tissue,
promote
GPs
DGs
FFAs,
enhance
consumption
FFAs
through
thermogenic
pathways,
thereby
exert
lipolytic
hepatoprotective
functions.
Язык: Английский