Hallmarks of regeneration
Cell stem cell,
Год журнала:
2024,
Номер
31(9), С. 1244 - 1261
Опубликована: Авг. 19, 2024
Язык: Английский
Histone H4 lysine 20 monomethylation is not a mark of transcriptional silencers
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
Transcriptional
silencers
are
cis
-regulatory
elements
that
downregulate
the
expression
of
target
genes.
Although
thousands
have
been
identified
experimentally,
a
predictive
chromatin
signature
has
not
found.
H4K20me1
previously
was
reported
to
be
highly
enriched
among
human
silencers,
but
our
reanalysis
those
data
using
an
appropriate
background
revealed
enrichment
is
only
marginal.
We
generated
ChIP-seq
profiles
in
Drosophila
S2
cells,
which
similarly
showed
does
mark
and
instead
associated
with
active
transcription.
Silencers
remain
poorly
annotated,
difficult
predict
class
whose
specific
features
identified.
Язык: Английский
Common and specific gene regulatory programs in zebrafish caudal fin regeneration at single-cell resolution
Genome Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Following
amputation,
zebrafish
regenerate
their
injured
caudal
fin
through
lineage-restricted
reprogramming.
Although
previous
studies
have
charted
various
genetic
and
epigenetic
dimensions
of
this
process,
the
intricate
gene
regulatory
programs
shared
by,
or
unique
to,
different
regenerating
cell
types
remain
underinvestigated.
Here,
we
mapped
landscape
regeneration
by
applying
paired
snRNA-seq
snATAC-seq
on
uninjured
fins.
This
map
delineates
dynamics
predominant
populations
at
multiple
stages
regeneration.
We
observe
a
marked
increase
in
accessibility
chromatin
regions
associated
with
regenerative
developmental
processes
1
dpa,
followed
gradual
closure
across
major
later
stages.
pattern
is
distinct
from
that
transcriptomic
dynamics,
which
characterized
several
waves
upregulation
downregulation.
identified
vivo
validated
cell-type-specific
position-specific
regeneration-responsive
enhancers
constructed
networks
type
stage.
Our
single-cell
resolution
provides
new
insights
into
mechanisms
serves
as
valuable
resource
for
community.
Язык: Английский
Cardiac enhancers: Gateway to the regulatory mechanisms of heart regeneration
Ian J. Begeman,
Megan E Guyer,
Junsu Kang
и другие.
Seminars in Cell and Developmental Biology,
Год журнала:
2025,
Номер
170, С. 103610 - 103610
Опубликована: Апрель 10, 2025
Язык: Английский
Blueprints for healing: central nervous system regeneration in zebrafish and neonatal mice
BMC Biology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 30, 2025
In
adult
mammals,
including
humans,
neurons,
and
axons
in
the
brain
spinal
cord
are
inherently
incapable
of
regenerating
after
injury.
Studies
animals
with
innate
capacity
for
regeneration
providing
valuable
insights
into
mechanisms
driving
tissue
healing.
The
aim
this
review
is
to
summarize
recent
data
on
zebrafish
neonatal
mice.
We
infer
that
elucidating
these
understanding
how
why
they
lost
mammals
will
contribute
development
strategies
promote
central
nervous
system
regeneration.
Язык: Английский