Опубликована: Окт. 18, 2024
Mutations in genes involved DNA damage repair (DDR) often lead to premature aging syndromes. While recent evidence suggests that inflammation, alongside mutation accumulation and cell death, may drive disease phenotypes, its precise contribution
Язык: Английский
Trends in Cell Biology, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
2
Biology Open, Год журнала: 2023, Номер 12(2)
Опубликована: Фев. 15, 2023
ABSTRACT During aging, animals experience a decline in proteostasis activity, including loss of stress-response activation, culminating the accumulation misfolded proteins and toxic aggregates, which are causal onset some chronic diseases. Finding genetic pharmaceutical treatments that can increase organismal lengthen life is an ongoing goal current research. The regulation stress responses by cell non-autonomous mechanisms appears to be potent way impact healthspan. In this Review, we cover recent findings intersection with special focus on articles preprints published between November 2021 October 2022. A significant number papers during time increased our understanding how cells communicate each other proteotoxic stress. Finally, also draw attention emerging datasets explored generate new hypotheses explain age-related collapse.
Язык: Английский
Процитировано
5
Proceedings of the National Academy of Sciences, Год журнала: 2024, Номер 122(1)
Опубликована: Дек. 30, 2024
C-Terminal cyclic imides are posttranslational modifications that can arise from spontaneous intramolecular cleavage of asparagine or glutamine residues resulting in a form irreversible protein damage. These damage events recognized and removed by the E3 ligase substrate adapter cereblon (CRBN), indicating these aging-related may require cellular quality control mechanisms to prevent deleterious effects. However, factors determine peptide susceptibility C-terminal imide formation their effect on stability have not been explored detail. Here, we characterize primary secondary structures peptides proteins promote intrinsic comparison deamidation, related Extrinsic effects solution properties stressors proteome additionally like glutathione synthetase susceptible aggregation if products CRBN. This systematic investigation provides insight into regions prone unexpectedly frequent modifications, this stability, biological role
Язык: Английский
Процитировано
1
ACTA HISTOCHEMICA ET CYTOCHEMICA, Год журнала: 2024, Номер 57(4), С. 137 - 147
Опубликована: Авг. 22, 2024
While the rapid decrease in estrogen is well known as main cause of postmenopausal osteoporosis women, precise pathogenesis senile elderly regardless gender largely unknown. The age-related epigenetic regulation receptor activator NF-κB (RANK) gene expression was investigated with use a high-passaged mouse osteoclast progenitor cell line, RAW264.7, an
Язык: Английский
Процитировано
1
Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2024, Номер unknown
Опубликована: Сен. 16, 2024
ABSTRACT Skeletal muscle is a highly adaptable tissue, finely tuned by various physiological and pathological factors. Whilst the pivotal role of skeletal in overall health widely acknowledged, unravelling underlying molecular mechanisms poses ongoing challenges. Protein ubiquitylation, crucial post‐translational modification, involved regulating most biological processes. This widespread impact achieved through diverse set enzymes capable generating structurally functionally distinct ubiquitin modifications on proteins. The complexity protein ubiquitylation has presented significant challenges not only identifying ubiquitylated proteins but also characterising their functional significance. Mass spectrometry enables in‐depth analysis modification status, offering powerful tool for studying its diversity: an approach termed ubiquitylomics. Ubiquitylomics been employed to tackle different perspectives including limited global quantification substrates linkages, site recognition crosstalk with other modifications. As field mass continues evolve, usage ubiquitylomics unravelled novel insights into regulatory governing biology. However, research predominantly conducted cellular models, limiting our understanding signalling events driving By integrating intricate landscape dynamic shifts physiology, promises deepen biology lay foundation developing transformative muscle‐related therapeutics. review aims articulate how can be utilised researchers address aspects muscle. We explore methods used experiments, highlight relevant literature employing context outline considerations experimental design.
Язык: Английский
Процитировано
1
EMBO Reports, Год журнала: 2024, Номер 25(12), С. 5265 - 5276
Опубликована: Ноя. 19, 2024
Язык: Английский
Процитировано
1
Ageing Research Reviews, Год журнала: 2024, Номер 104, С. 102616 - 102616
Опубликована: Дек. 5, 2024
Since the first description of a set characteristics aging as so-called hallmarks or pillars in 2013/2014, these have served guideposts for research biology. They been examined range contexts, across tissues, response to disease conditions environmental factors, and benchmark various anti-aging interventions. While were intended capture generalizable aging, they are derived mostly from studies rodents humans. Comparative including species animal tree life great promise reveal new insights into mechanistic foundations there is diversity lifespan age-associated physiological changes. However, it unclear how well defined apply diverse species. Here, we review each twelve by Lopez-Otin 2023 with respect availability data We evaluate current methods used assess their potential be adapted comparative studies. Not unexpectedly, find that supporting described restricted humans few model systems no available many clades. Similarly, not all can easily assessed at least half hallmarks, today employed fill this gap knowledge, suggesting prioritized while developed study remaining hallmarks.
Язык: Английский
Процитировано
1
Cold Spring Harbor Protocols, Год журнала: 2023, Номер 2024(3), С. pdb.over107737 - pdb.over107737
Опубликована: Апрель 26, 2023
The African turquoise killifish
Язык: Английский
Процитировано
3
Опубликована: Окт. 18, 2024
Mutations in genes involved DNA damage repair (DDR) often lead to premature aging syndromes. While recent evidence suggests that inflammation, alongside mutation accumulation and cell death, may drive disease phenotypes, its precise contribution
Язык: Английский
Процитировано
0